INT103271

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Context Info
Confidence 0.24
First Reported 2002
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 1.32
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Sit1)
Anatomy Link Frequency
blood 2
limb 1
Sit1 (Mus musculus)
Pain Link Frequency Relevance Heat
Restless leg syndrome 5 90.16 High High
Parenteral administration 4 66.24 Quite High
Morphine 2 50.00 Quite Low
abdominal pain 4 25.48 Quite Low
peripheral neuropathy 4 20.36 Low Low
vagus nerve 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sleep Disorders 5 93.52 High High
Restless Legs Syndrome 5 90.16 High High
Hypoglycemia 8 75.36 Quite High
Diabetes Mellitus 72 73.92 Quite High
Diarrhoea 8 38.00 Quite Low
Constipation 8 27.40 Quite Low
Fecal Incontinence 4 26.72 Quite Low
Abdominal Pain 4 25.48 Quite Low
Gastric Motility Disorder 4 24.84 Low Low
Peripheral Neuropathy 4 20.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cisapride, though it did not show any significant effect on SIT in normal mice, was able to reverse morphine induced delay in SIT significantly (P<0.001) followed by metoclopramide and mosapride.
Regulation (effect) of SIT
1) Confidence 0.24 Published 2003 Journal World J. Gastroenterol. Section Body Doc Link 12679931 Disease Relevance 0 Pain Relevance 0
These findings suggest that there is only a small pathological significance for periodic limb movements, and demonstrate the efficacy of SIT and PSQI for evaluating the severity of these disorders.
Regulation (efficacy) of SIT in limb
2) Confidence 0.23 Published 2002 Journal Psychiatry Clin. Neurosci. Section Abstract Doc Link 12047601 Disease Relevance 0.83 Pain Relevance 0.41
In contrast to glycaemic states, with all the doses of insulin administration a positive relationship between the changes in SIT and insulinemic states was recorded (Fig 3).
Regulation (changes) of SIT
3) Confidence 0.15 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0.05 Pain Relevance 0.03
Insulin at the lowest dose produced an acceleratory effect on SIT that was independent of blood glucose and serum insulin levels in normal mice.



Regulation (effect) of SIT in blood
4) Confidence 0.15 Published 2006 Journal BMC Pharmacol Section Abstract Doc Link PMC1444921 Disease Relevance 0.30 Pain Relevance 0
Effect of insulin administration on % change in SIT and serum insulin level
Regulation (change) of SIT
5) Confidence 0.15 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0.06 Pain Relevance 0.03
Effect of insulin administration on % change in SIT and blood glucose levels
Regulation (change) of SIT in blood
6) Confidence 0.15 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0.07 Pain Relevance 0

General Comments

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