INT103272

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Context Info
Confidence 0.26
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.66
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Dio1) endoplasmic reticulum (Dio1)
Anatomy Link Frequency
neurons 2
hippocampus region 2
striatum 2
Dio1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 300 100.00 Very High Very High Very High
agonist 12 100.00 Very High Very High Very High
Enkephalin 4 99.08 Very High Very High Very High
Hippocampus 6 98.08 Very High Very High Very High
antagonist 17 93.80 High High
Inflammation 13 91.84 High High
Inflammatory response 6 85.28 High High
dopamine receptor 29 75.00 Quite High
cytokine 3 73.92 Quite High
Nucleus accumbens 12 64.64 Quite High
Disease Link Frequency Relevance Heat
Wrinkles 1 98.64 Very High Very High Very High
Catalepsy 1 95.64 Very High Very High Very High
Targeted Disruption 3 94.08 High High
INFLAMMATION 21 91.84 High High
Stress 3 88.04 High High
Sprains And Strains 18 79.84 Quite High
Phototoxic Dermatitis 1 75.00 Quite High
Adhesions 1 74.32 Quite High
Hyperplasia 1 67.64 Quite High
Pressure And Volume Under Development 2 66.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Deletion of the DA D1 receptor increased the responsiveness of enkephalin neurons to haloperidol, in that haloperidol-induced increases in c-Fos and catalepsy were enhanced in D1 receptor knockout mice.
Positive_regulation (increased) of Gene_expression (Deletion) of D1 in neurons associated with targeted disruption, dopamine, catalepsy and enkephalin
1) Confidence 0.26 Published 2002 Journal J. Chem. Neuroanat. Section Abstract Doc Link 12048106 Disease Relevance 0.19 Pain Relevance 0.54
Connor et al. [17] have shown that NPD1, resolvin D1, and resolvin E1 (all derivatives of ?
Positive_regulation (derivatives) of Gene_expression (shown) of D1
2) Confidence 0.19 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2834569 Disease Relevance 0.46 Pain Relevance 0.18
Bronikowski and colleagues (2004) investigated gene expression changes in the
    hippocampus region of the brain and found that mice selectively bred for high wheel running had
    a 20% increase in D2 and D4 receptor expression (D1-like receptors were not analyzed in this
    study) compared to control line mice 16. 
Positive_regulation (increase) of Gene_expression (expression) of D1 in hippocampus region associated with hippocampus
3) Confidence 0.07 Published 2010 Journal International Journal of Biological Sciences Section Body Doc Link PMC2836544 Disease Relevance 0.15 Pain Relevance 0.19
Pharmacological studies show that Fos immunoreactivity in the striatum and other key regions of
   the brain is increased following administration of D1 and D2 agonists 58, 66, 69, 109, 126, suggesting Fos may be important as a downstream gene regulated by dopaminergic
   signaling. ?
Positive_regulation (administration) of Gene_expression (agonists) of D1 in striatum associated with agonist
4) Confidence 0.06 Published 2010 Journal International Journal of Biological Sciences Section Body Doc Link PMC2836544 Disease Relevance 0 Pain Relevance 0.25
UVB exposure enhanced the expression of p53, c-fos, cyclins D1 and A, and PCNA 24 h after irradiation.
Positive_regulation (enhanced) of Gene_expression (expression) of cyclins D1
5) Confidence 0.02 Published 2004 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 15020200 Disease Relevance 0.86 Pain Relevance 0.18

General Comments

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