INT103281

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Context Info
Confidence 0.67
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 5.95
Pain Relevance 3.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CCL5) aging (CCL5) extracellular region (CCL5)
cell-cell signaling (CCL5) cytoplasm (CCL5)
Anatomy Link Frequency
monocytes 1
synovial cells 1
melanocytes 1
fibroblasts 1
CCL5 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 260 100.00 Very High Very High Very High
Inflammation 207 100.00 Very High Very High Very High
orphanin 7 99.56 Very High Very High Very High
cytokine 72 99.18 Very High Very High Very High
Arthritis 203 96.04 Very High Very High Very High
methotrexate 57 90.84 High High
rheumatoid arthritis 42 90.08 High High
endometriosis 2 87.12 High High
Inflammatory response 12 86.56 High High
pain pelvic 2 85.12 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 213 100.00 Very High Very High Very High
Hepatitis C Virus Infection 378 96.76 Very High Very High Very High
Juvenile Chronic Polyarthritis 160 96.04 Very High Very High Very High
Rheumatoid Arthritis 42 90.08 High High
Arthritis 50 89.60 High High
Disease 77 79.36 Quite High
Injury 25 79.28 Quite High
Cancer 30 78.56 Quite High
Wound Healing 2 77.52 Quite High
Metastasis 2 71.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, mRNA for CCL5 was present in all eight SFMC samples and at high levels in five out of eight of these (Figure 1a).
Transcription (present) of CCL5
1) Confidence 0.67 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.40 Pain Relevance 0.40
These studies indicate that prolonged progestin exposure down-regulates endometrial RANTES gene transcription in vitro.
Transcription (transcription) of RANTES
2) Confidence 0.62 Published 2002 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 12050207 Disease Relevance 0.27 Pain Relevance 0.27
Levels of mRNA of the three inflammatory chemokines CCL5 (RANTES), CCL3 (MIP-1?)
Transcription (Levels) of RANTES associated with chemokine and inflammation
3) Confidence 0.60 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.69 Pain Relevance 0.43
In contrast to CCL3 and CXCL10, levels of transcription of mRNA for CCL5 were clearly increased in synovial cells, predominantly in CD8+ T cells, in all three subtypes of JIA investigated.
Transcription (transcription) of CCL5 in synovial cells associated with arthritis
4) Confidence 0.51 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.67 Pain Relevance 0.44
There was no difference in transcript levels for CCL5 and CXCL12 in HFAs (data not shown).
Transcription (levels) of CCL5
5) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.01 Pain Relevance 0.20
There was no difference in transcript levels for CCL5 and CXCL12 in HFAs (data not shown).
Transcription (transcript) of CCL5
6) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.01 Pain Relevance 0.20
Levels of mRNA of the three inflammatory chemokines CCL5 (RANTES), CCL3 (MIP-1?)
Transcription (Levels) of CCL5 associated with chemokine and inflammation
7) Confidence 0.45 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.69 Pain Relevance 0.43
In synoviocytes, BEB3-crosslinked hTWEAK increased the mRNA level of IL-8, MCP-1, RANTES, IP-10 and MIP-1?.
Transcription (level) of RANTES
8) Confidence 0.21 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0.24 Pain Relevance 0.13
When stimulated by TLR ligands, human melanocytes can: (1) release IL-6 and IL-8 cytokines, (2) enhance chemokine (CCL2, CCL3, and CCL5) mRNA production, (3) upregulate phosphorylated I?
Transcription (production) of CCL5 in melanocytes associated with chemokine and cytokine
9) Confidence 0.18 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2933899 Disease Relevance 0.59 Pain Relevance 0.17
However, nociceptin does not appear to regulate the expression of these chemokines at the level of transcription, as CCL2/MCP-1 and CCL5/RANTES mRNA levels following nociceptin treatment of monocytes were essentially normal.
Transcription (levels) of CCL5/RANTES in monocytes associated with chemokine and orphanin
10) Confidence 0.18 Published 2008 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 18247127 Disease Relevance 0.16 Pain Relevance 0.91
In dermal fibroblasts, BEB3-crosslinked hTWEAK was shown to increase the mRNA level of three chemokines of the CXC or CC families, IL-8, MCP-1 and RANTES.
Transcription (level) of RANTES in fibroblasts associated with chemokine
11) Confidence 0.09 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0.22 Pain Relevance 0.13

General Comments

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