INT103289

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Context Info
Confidence 0.35
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 15
Total Number 17
Disease Relevance 13.67
Pain Relevance 7.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il10) extracellular region (Il10) intracellular (Il10)
Anatomy Link Frequency
macrophage 2
blood 1
glial cells 1
Il10 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 403 100.00 Very High Very High Very High
cytokine 191 99.78 Very High Very High Very High
Lasting pain 37 99.60 Very High Very High Very High
Pain 64 99.16 Very High Very High Very High
Hyperalgesia 309 97.68 Very High Very High Very High
spinal inflammation 24 97.00 Very High Very High Very High
Angina 8 96.64 Very High Very High Very High
Antihyperalgesic 4 94.88 High High
anesthesia 25 74.08 Quite High
allodynia 56 73.84 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 457 100.00 Very High Very High Very High
Cancer 27 99.88 Very High Very High Very High
Necrosis 23 99.64 Very High Very High Very High
Pain 100 99.60 Very High Very High Very High
Hyperalgesia 320 97.68 Very High Very High Very High
Disease 45 97.24 Very High Very High Very High
Low Back Pain 30 97.00 Very High Very High Very High
Cv General 3 Under Development 8 96.64 Very High Very High Very High
Myocardial Infarction 5 95.20 Very High Very High Very High
Premature Birth 27 92.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Results indicate a difference in collagen deposition and myofibroblast development around both materials with involvement of TGFbeta, IFNgamma and IL10.
IL10 Binding (involvement) of
1) Confidence 0.35 Published 2010 Journal J Biomater Sci Polym Ed Section Abstract Doc Link 20534192 Disease Relevance 0.30 Pain Relevance 0.23
and low IL-10 (A+ and G-, respectively) while anti-inflammatory was defined as individuals expressing the alleles consistent with low TNF-?
IL-10 Binding (individuals) of associated with inflammation
2) Confidence 0.34 Published 2009 Journal The Open Dentistry Journal Section Body Doc Link PMC2745565 Disease Relevance 1.05 Pain Relevance 0.19
The effects of microinjection of IL-10, fluorocitrate and minocycline on orofacial inflammatory hyperalgesia
IL-10 Binding (microinjection) of associated with hyperalgesia and inflammation
3) Confidence 0.33 Published 2009 Journal Mol Pain Section Body Doc Link PMC2806354 Disease Relevance 1.20 Pain Relevance 1.12
The effects of microinjection of IL-10, fluorocitrate and minocycline on IL-1?
IL-10 Binding (microinjection) of
4) Confidence 0.33 Published 2009 Journal Mol Pain Section Body Doc Link PMC2806354 Disease Relevance 0.96 Pain Relevance 0.75
Importantly, IL-10 suppresses p38 mitogen-activated protein kinase activation in immune cells [81], which may be a key interface between IL-10 and glial cells in producing antihyperalgesia [see [56]].
IL-10 Binding (interface) of in glial cells
5) Confidence 0.33 Published 2009 Journal Mol Pain Section Body Doc Link PMC2806354 Disease Relevance 0.97 Pain Relevance 0.92
While these data support the involvement of both glia and inflammatory cytokines in persistent pain, the mechanisms of interactions between IL-10 and glia during the pain processing are only speculative.
IL-10 Binding (interactions) of associated with pain, inflammation, lasting pain and cytokine
6) Confidence 0.32 Published 2009 Journal Mol Pain Section Body Doc Link PMC2806354 Disease Relevance 1.24 Pain Relevance 1.12
Although there have been conflicting reports the majority suggest that the IL10 ATA promoter haplotype and alleles comprising the haplotype are associated with low protein levels in Caucasians [24].
IL10 Binding (associated) of
7) Confidence 0.29 Published 2005 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC554771 Disease Relevance 1.04 Pain Relevance 0.20
Its effect on IL-10 bioactivity in vitro, if any, is currently under investigation



IL-10 Binding (bioactivity) of
8) Confidence 0.21 Published 2005 Journal Mol Pain Section Body Doc Link PMC1079940 Disease Relevance 0 Pain Relevance 0
Possession of a high producer TNF-alpha and a low producer IL-10 genotype were significantly more prevalent in IBS (9%) versus controls (3%, p= 0.035; OR 3.11, 95% CI 1.03-9.36) and in diarrhea (20%) compared to other IBS subtypes (<4%, p= 0.026).
IL-10 Binding (genotype) of
9) Confidence 0.19 Published 2005 Journal Am. J. Gastroenterol. Section Body Doc Link 16279907 Disease Relevance 0.12 Pain Relevance 0
Mediators such as macrophage migration inhibitory factor (MIF) and interleukin-10 (IL-10) are thought to be involved in several inflammatory conditions, including AS.
IL-10 Binding (macrophage) of in macrophage associated with spinal inflammation and inflammation
10) Confidence 0.14 Published 2010 Journal Mod Rheumatol Section Abstract Doc Link 19787418 Disease Relevance 1.43 Pain Relevance 0.85
Mediators such as macrophage migration inhibitory factor (MIF) and interleukin-10 (IL-10) are thought to be involved in several inflammatory conditions, including AS.
interleukin-10 Binding (macrophage) of in macrophage associated with spinal inflammation and inflammation
11) Confidence 0.14 Published 2010 Journal Mod Rheumatol Section Abstract Doc Link 19787418 Disease Relevance 1.43 Pain Relevance 0.85
Inflammatory cytokines (IL-6 and IL-10), IGF-I and its binding proteins (IGFBP-I, IGFBP-III) were analysed from blood samples, drawn between days 3 and 7 as well as between days 8 and 10 after ICU admission.
IL-10 Spec (analysed) Binding (binding) of in blood associated with inflammation and cytokine
12) Confidence 0.13 Published 2010 Journal Crit Care Section Body Doc Link PMC2911767 Disease Relevance 0.93 Pain Relevance 0.15
CONCLUSIONS: TNFalpha and IL10 promotor variants are not associated with a manifestation of chronic pancreatitis or pancreatic cancer.
IL10 Binding (associated) of
13) Confidence 0.12 Published 2003 Journal Eur J Gastroenterol Hepatol Section Body Doc Link 14560157 Disease Relevance 0 Pain Relevance 0
Anti-inflammatory phytotherapy failure was associated with low TNF-alpha and high IL-10 phenotypes, which may help define a subset of patients with the chronic pelvic pain syndrome without an inflammatory etiology.


IL-10 Binding (associated) of
14) Confidence 0.06 Published 2002 Journal J. Urol. Section Body Doc Link 12050565 Disease Relevance 0 Pain Relevance 0
Cytokine levels (interleukin-6, interleukin-8, interleukin-10, and tumor necrosis factor-alpha) were estimated by enzyme-linked immunosorbent assay (ELISA).
interleukin-10 Binding (interleukin-8) of associated with necrosis, cancer and cytokine
15) Confidence 0.05 Published 2009 Journal Angiology Section Abstract Doc Link 18796448 Disease Relevance 1.48 Pain Relevance 0.72
The levels of interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-?)
interleukin-10 Binding (interleukin-6) of associated with necrosis and cancer
16) Confidence 0.02 Published 2010 Journal Immun Ageing Section Body Doc Link PMC2933667 Disease Relevance 0.73 Pain Relevance 0.16
The levels of interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-?)
IL-10 Binding (interleukin-6) of associated with necrosis and cancer
17) Confidence 0.02 Published 2010 Journal Immun Ageing Section Body Doc Link PMC2933667 Disease Relevance 0.73 Pain Relevance 0.16

General Comments

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