INT1033

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Context Info
Confidence 0.68
First Reported 1975
Last Reported 2011
Negated 15
Speculated 12
Reported most in Body
Documents 507
Total Number 519
Disease Relevance 131.76
Pain Relevance 147.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ca2) extracellular space (Ca2) lyase activity (Ca2)
response to stress (Ca2) cytoplasm (Ca2)
Anatomy Link Frequency
neurons 31
astrocytes 24
neuronal 10
microglia 9
reticulum 7
Ca2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 1473 100.00 Very High Very High Very High
imagery 1194 100.00 Very High Very High Very High
long-term potentiation 793 100.00 Very High Very High Very High
Hippocampus 781 100.00 Very High Very High Very High
Kinase C 576 100.00 Very High Very High Very High
Somatostatin 23 100.00 Very High Very High Very High
qutenza 3218 99.98 Very High Very High Very High
Glutamate 1899 99.98 Very High Very High Very High
Action potential 1589 99.98 Very High Very High Very High
nMDA receptor 1198 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 552 100.00 Very High Very High Very High
Hypoxia 4103 99.98 Very High Very High Very High
Acidosis 2195 99.98 Very High Very High Very High
Neuropathic Pain 320 99.96 Very High Very High Very High
Hypothermia 10 99.92 Very High Very High Very High
Myocardial Stunning 8 99.86 Very High Very High Very High
Diabetes Mellitus 479 99.84 Very High Very High Very High
Apoptosis 1075 99.82 Very High Very High Very High
Anaerobic Bacterial Infections 23 99.82 Very High Very High Very High
Nociception 761 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have previously shown that activity-induced alkaline transients in the CAI region are due to an influx of Ca2+ into neurons, which triggers an influx of H+ ions probably caused by activation of a plasmalemmal Ca2+/H+ ATPase.
Positive_regulation (activation) of Ca2 in neurons
1) Confidence 0.68 Published 1996 Journal J. Neurophysiol. Section Abstract Doc Link 8793748 Disease Relevance 0 Pain Relevance 0.23
Pretreatment with the calcium channel blockers nimodipine (1 mg/kg s.c.), diltiazem (10 mg/kg s.c.) and verapamil (2.5 mg/kg s.c.) potentiated the hypothermic effect of U-50,488H as well as the stimulation of Ca2+/Mg2+ ATPase in hypothalamus.
Positive_regulation (stimulation) of Ca2 in hypothalamus associated with calcium channel
2) Confidence 0.67 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3028838 Disease Relevance 0.07 Pain Relevance 0.42
One possible explanation therefore is that intracellular acidosis causes a sustained increase in Ca2+ leak from the ER.
Positive_regulation (increase) of Ca2 associated with acidosis
3) Confidence 0.57 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765625 Disease Relevance 0.46 Pain Relevance 0.06
Figure 6Different patterns of Ca2+ signals are induced by high compared to low concentrations of nucleotides.
Positive_regulation (induced) of Ca2
4) Confidence 0.55 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096653 Disease Relevance 0 Pain Relevance 0.08
Oscillatory Ca2+ activity induced by low doses of nucleotides
Positive_regulation (induced) of Ca2
5) Confidence 0.55 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096653 Disease Relevance 0 Pain Relevance 0.04
Depletion of Ca2+ from the ER stores is known to be the starting signal of induction of the capacitative Ca2+ influx mainly described in non-excitable cells, among them microglia [21].
Positive_regulation (induction) of Ca2 in microglia
6) Confidence 0.55 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096653 Disease Relevance 0 Pain Relevance 0
The perivascular nerve network expresses a Ca2+ receptor that is activated by high extracellular Ca2+ concentrations and causes vasorelaxation in resistance arteries.
Positive_regulation (activated) of Ca2 in nerve
7) Confidence 0.50 Published 2009 Journal Vascul. Pharmacol. Section Abstract Doc Link 19056515 Disease Relevance 0 Pain Relevance 0.08
Thus, these synaptically mediated Ca2+ responses in glial cells involve the activation of L-type Ca2+ channels, group I/II metabotropic glutamate receptors, and non-NMDA receptors.
Positive_regulation (activation) of Ca2 in glial cells associated with nmda receptor and glutamate receptor
8) Confidence 0.50 Published 2001 Journal Hippocampus Section Abstract Doc Link 11345120 Disease Relevance 0 Pain Relevance 0.87
Chronic inhibition of intracellular Ca2+ release or protein kinase C activation significantly reduces the development of morphine dependence.
Positive_regulation (activation) of Ca2 associated with addiction, kinase c and morphine
9) Confidence 0.49 Published 1996 Journal Eur. J. Pharmacol. Section Title Doc Link 8739205 Disease Relevance 0.27 Pain Relevance 0.75
This hypothermic effect of U-50,488H was accompanied by an enhanced activity of Ca2+/Mg2+ ATPase in crude synaptosomal (P2) fractions obtained from hypothalamus but not from cortex or cerebellum.
Positive_regulation (enhanced) of Ca2 in cerebellum
10) Confidence 0.49 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3028838 Disease Relevance 0.07 Pain Relevance 0.37
The secretory response of the rat colon to the flavonol quercetin is dependent on Ca2+-calmodulin.
Positive_regulation (dependent) of Ca2 in colon
11) Confidence 0.49 Published 2000 Journal Exp. Physiol. Section Title Doc Link 10825411 Disease Relevance 0 Pain Relevance 0.16
These results indicate that local application of glutamate increases intracellular Ca2+ levels in glial cells via the activation of L-type Ca2+ channels, NMDA receptors, and metabotropic glutamate receptors.
Positive_regulation (activation) of Ca2 in glial cells associated with glutamate, glutamate receptor and nmda receptor
12) Confidence 0.47 Published 2001 Journal Hippocampus Section Abstract Doc Link 11345120 Disease Relevance 0 Pain Relevance 0.86
In this study, activity of Ca2+ ATPase was significantly decreased by selenite administration with a corresponding increase in Ca2+.
Positive_regulation (increase) of Ca2
13) Confidence 0.46 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2779145 Disease Relevance 0.26 Pain Relevance 0
Selenite cataractogenesis is found to have increased Ca2+ uptake and is highest in the nucleus [10].
Positive_regulation (increased) of Ca2 in nucleus
14) Confidence 0.46 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2779145 Disease Relevance 0.70 Pain Relevance 0
In spite of their important regulatory functions under normal physiological conditions, accumulated levels of Ca2+ are observed to result in the proteolysis of crystallins associated with cataractogenesis.
Positive_regulation (accumulated) of Ca2
15) Confidence 0.46 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2779145 Disease Relevance 0.17 Pain Relevance 0
Oxidative damage of mitochondria has been shown to increase cellular Ca2+ levels [48,49] and contribute to lens fiber cell globulization in vitro [50].
Positive_regulation (increase) of Ca2 in lens fiber
16) Confidence 0.46 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2779145 Disease Relevance 0.15 Pain Relevance 0
On the other hand, sarcolemmal Mg2+-ATPase and Ca2+-ATPase activities, but not Na+-K+-ATPase activity, were increased by all these drugs.
Positive_regulation (increased) of Ca2
17) Confidence 0.45 Published 1975 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 130965 Disease Relevance 0 Pain Relevance 0.28
In rat cerebral cortex, the enzyme adaptation to four-week-treatment with delta-yohimbine or clonidine was characterized by increase in both high- and low-affinity Ca2+ -ATPase activities.
Positive_regulation (increase) of Ca2 in cerebral cortex associated with cerebral cortex and clonidine
18) Confidence 0.45 Published 1993 Journal Neurochem. Res. Section Abstract Doc Link 8099718 Disease Relevance 0 Pain Relevance 0.27
To test our hypothesis, either pre-contracted aortas isolated from rats after sensory denervation with capsaicin or aortic rings acutely denervated with phenol were stimulated to relax with increasing extracellular Ca2+ concentration.
Positive_regulation (increasing) of Ca2 in aortas associated with qutenza
19) Confidence 0.44 Published 2009 Journal Vascul. Pharmacol. Section Abstract Doc Link 19056515 Disease Relevance 0 Pain Relevance 0.13
Ca2+ extrusion from the cytosol following a modest increase in [Ca2+]i was significantly and progressively inhibited in the presence of anoxia.
Positive_regulation (increase) of Ca2 associated with hypoxia
20) Confidence 0.43 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.66 Pain Relevance 0

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