INT103304

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Context Info
Confidence 0.48
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 8.66
Pain Relevance 2.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Mif) cell proliferation (Mif) extracellular space (Mif)
extracellular region (Mif) nucleus (Mif) cytoplasm (Mif)
Anatomy Link Frequency
Macrophage 2
monocyte 1
neutrophil 1
Mif (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 129 99.64 Very High Very High Very High
chemokine 20 99.36 Very High Very High Very High
halothane 1 99.00 Very High Very High Very High
rheumatoid arthritis 67 95.52 Very High Very High Very High
cytokine 54 92.64 High High
fibrosis 2 87.12 High High
cva 2 86.96 High High
Paracetamol 4 79.60 Quite High
Central nervous system 33 75.56 Quite High
antagonist 4 67.12 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 159 99.64 Very High Very High Very High
Toxicity 5 99.48 Very High Very High Very High
Infection 167 99.12 Very High Very High Very High
Apoptosis 56 98.56 Very High Very High Very High
Injury 12 97.82 Very High Very High Very High
Disease 71 97.04 Very High Very High Very High
Malignant Neoplastic Disease 4 96.00 Very High Very High Very High
Rheumatoid Arthritis 67 95.52 Very High Very High Very High
Skin Cancer 2 94.64 High High
Togavirus Infection 225 94.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This work suggests that apart from a potential role for the enzymatic activity, the tautomerase site is also required for important protein–protein interactions.
Positive_regulation (required) of tautomerase site
1) Confidence 0.48 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 0.86 Pain Relevance 0.06
The higher levels of MIF associated with this particular variant also correlated with progressive disease.16 In relation to malignant diseases, individuals carrying the seven-repeat allele were also found to have an increased incidence of prostate cancer.17 MIF biological activity has also been implicated in the pathogenesis of atherosclerosis and abdominal aortic aneurysm.18 In the context of atherosclerosis, MIF has also been identified as a non-cognate receptor of CXCR2 and CXCR4 and has functional chemokine activity in evolving atherosclerosis mediating monocyte arrest and the formation of plaques.19 Additionally, as part of this disease process MIF can induce the CXCR ligand, Interleukin (IL)-8 and regulators of macrophage infiltration ICAM-1 and CD44, confirming its relevance in this disease.20
Positive_regulation (levels) of MIF in monocyte associated with chemokine, malignant neoplastic disease, cva, increased venous pressure under development, disease and reprotox - general 1
2) Confidence 0.48 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.65 Pain Relevance 0.30
Though over-expressed in the microarray, only a marginal increase in expression of Mif was observed at 96 hr post infection by PCR, where increases in inflammation and neutrophil migration were also observed.
Positive_regulation (increase) of Mif in neutrophil associated with inflammation and infection
3) Confidence 0.44 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.70 Pain Relevance 0.44
Our results demonstrate that genes related to important immune pathways such as antigen presentation, inflammation, apoptosis and response to virus (Cxcl10, CxCl11, Ccl5, Ifr7, Ifi27 Oas1b, Fcerg1,Mif, Clusterin and MHC class II) were upregulated as a result of virus infection.
Positive_regulation (upregulated) of Mif associated with inflammation, apoptosis and infection
4) Confidence 0.41 Published 2008 Journal BMC Genomics Section Abstract Doc Link PMC2440554 Disease Relevance 1.14 Pain Relevance 0.09
Interestingly, chemokines such as Cxcl9, Cxcl10, Cxcl11, Cxcl13, Ccl3, Ccl5 and Ccl12, Fc-receptor such as Fcer1g, and Mif genes were upregulated.
Positive_regulation (upregulated) of Mif associated with chemokine
5) Confidence 0.41 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.86 Pain Relevance 0.61
Using a guinea pig model of liver injury induced by bioactivation of the anesthetic drug, halothane, we found that toxicity was commensurate with an increase in serum macrophage migration inhibitory factor (MIF), a pro-inflammatory signal and counter-regulator of glucocorticoids, but only in susceptible animals.
Positive_regulation (increase) of MIF in macrophage associated with toxicity, inflammation, injury and halothane
6) Confidence 0.39 Published 2002 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 12051698 Disease Relevance 0.90 Pain Relevance 0.37
Macrophage migration inhibitory factor
Positive_regulation (Macrophage) of migration inhibitory factor in Macrophage
7) Confidence 0.20 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 0.55 Pain Relevance 0.18

General Comments

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