INT103305

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Context Info
Confidence 0.49
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.81
Pain Relevance 1.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Hmox1) enzyme binding (Hmox1) signal transducer activity (Hmox1)
cytosol (Hmox1) signal transduction (Hmox1) cell death (Hmox1)
Anatomy Link Frequency
liver 2
smooth muscle cells 2
Hmox1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 9 99.72 Very High Very High Very High
ischemia 26 98.64 Very High Very High Very High
cINOD 4 97.64 Very High Very High Very High
Inflammation 104 96.44 Very High Very High Very High
Inflammatory response 14 90.32 High High
cytokine 40 84.72 Quite High
fibrosis 44 79.04 Quite High
medulla 3 77.44 Quite High
Inflammatory mediators 4 73.32 Quite High
agonist 4 56.96 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 131 100.00 Very High Very High Very High
Cv Unclassified Under Development 18 98.64 Very High Very High Very High
Hypertension 72 98.42 Very High Very High Very High
Increased Venous Pressure Under Development 6 97.12 Very High Very High Very High
Hepatotoxicity 10 97.04 Very High Very High Very High
INFLAMMATION 123 96.92 Very High Very High Very High
Pressure And Volume Under Development 3 96.08 Very High Very High Very High
Stress 48 95.12 Very High Very High Very High
Toxicity 3 95.12 Very High Very High Very High
Cardiovascular Disease 4 91.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nitric oxide isn't the only mediator of Hmox-1 upregulation.
Positive_regulation (mediator) of Positive_regulation (upregulation) of Hmox-1
1) Confidence 0.49 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2258306 Disease Relevance 0.78 Pain Relevance 0.03
Abraham’s group found that upregulation of HO-1 can increase adiponectin levels in several animal models [42–46].
Positive_regulation (increase) of Positive_regulation (upregulation) of HO
2) Confidence 0.46 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635644 Disease Relevance 0.78 Pain Relevance 0.19
Treatment of rats with a hepatotoxic dose of acetaminophen (1 g/kg, ip) resulted in a time-dependent induction of HO-1 in the liver.
Positive_regulation (resulted) of Positive_regulation (induction) of HO-1 in liver associated with paracetamol
3) Confidence 0.46 Published 2002 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 12051994 Disease Relevance 0.35 Pain Relevance 0.53
Diabetic spontaneously hypertensive rat (SHR) and WKY (control) animals were treated with streptozotocin (STZ) to induce diabetes and stannous chloride (SnCl2) to upregulate HO-1.
Positive_regulation (induce) of Positive_regulation (upregulate) of HO associated with diabetes mellitus and hypertension
4) Confidence 0.43 Published 2008 Journal International Journal of Molecular Sciences Section Abstract Doc Link PMC2635644 Disease Relevance 1.08 Pain Relevance 0
Since activation of the HO system by an HO-1 inducer or by HO-1 gene therapy enhances hepatoprotection against warm and cold I/Ri in experimental animals [46,47], HO-1 upregulation upon treatment with CORM-2 may contribute to the beneficial effects on severity of I/Ri.
Positive_regulation (activation) of Positive_regulation (inducer) of HO-1
5) Confidence 0.24 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2873601 Disease Relevance 0.69 Pain Relevance 0.24
These data confirm earlier studies, in which activation of the HO system by an HO-1 inducer or by HO-1 gene therapy displayed enhancement of hepatoprotection against warm and cold I/Ri in experimental animals [47,48].
Positive_regulation (activation) of Positive_regulation (inducer) of HO-1
6) Confidence 0.24 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2873601 Disease Relevance 0.51 Pain Relevance 0.14
Once we verified that the treatment promotes upregulation of the HO-1 enzyme, we evaluated the cytoprotective role of HO-1.
Positive_regulation (promotes) of Positive_regulation (upregulation) of HO-1
7) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001459 Disease Relevance 0.31 Pain Relevance 0.04
We previously reported that eupatilin (5,7-dihydroxy-3,4,6-trimethoxyflavone) extracted from Artemisia asiaitica, augmented the cellular antioxidant defense capacity through induction of the antioxidant protein heme oxygenase-1 (HO-1), thereby protecting ileal smooth muscle cells from nonsteroidal anti-inflammatory drug (NSAID)-induced intestinal toxicity.
Positive_regulation (augmented) of Positive_regulation (induction) of protein heme oxygenase-1 in smooth muscle cells associated with toxicity, inflammation and cinod
8) Confidence 0.01 Published 2009 Journal Biol. Pharm. Bull. Section Abstract Doc Link 19336889 Disease Relevance 0.33 Pain Relevance 0.33

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