INT103316

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Context Info
Confidence 0.68
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 1.76
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE4A) signal transduction (PDE4A) plasma membrane (PDE4A)
nucleus (PDE4A) cytoplasm (PDE4A)
Anatomy Link Frequency
epithelial cells 1
smooth muscle cells 1
glands 1
PDE4A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 154 97.76 Very High Very High Very High
adenocard 9 95.12 Very High Very High Very High
rheumatoid arthritis 1 79.36 Quite High
cINOD 5 75.00 Quite High
Inflammatory mediators 16 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Neurotransmitter 4 5.00 Very Low Very Low Very Low
abdominal pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Vomiting 22 99.64 Very High Very High Very High
INFLAMMATION 179 97.76 Very High Very High Very High
Pulmonary Disease 126 93.48 High High
Targeted Disruption 8 91.44 High High
Disease 25 89.52 High High
Asthma 9 83.68 Quite High
Rheumatoid Arthritis 2 79.36 Quite High
Nicotine Addiction 12 47.40 Quite Low
Natriuresis 8 27.44 Quite Low
Airway Remodeling 4 17.68 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They are classified into 11 major families (PDE1-11) and the type 4 phosphodiesterase (PDE4) is a cAMP-specific enzyme localized in airway smooth muscle cells as well as in immune and inflammatory cells.
Localization (localized) of PDE4 in smooth muscle cells associated with inflammation
1) Confidence 0.68 Published 2002 Journal Curr. Pharm. Des. Section Abstract Doc Link 12052219 Disease Relevance 0.86 Pain Relevance 0.25
PDE4A and PDE4C are located on human chromosome 19 at 19p13.2 and 19p13.11, PDE4B is on chromosome 1p31 and PDE4D is on chromosome 5q12 (Bolger et al 1993; McLaughlin et al 1993; Milatovich et al 1994; Engels et al 1995; Horton et al 1995; Szpirer et al 1995; Nemoz et al 1996).
Localization (located) of PDE4A
2) Confidence 0.39 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0.21 Pain Relevance 0.03
The regulatory domains include the calmodulin binding domain found in PDE1, the cGMP binding (GAF) domains found in PDE2, 5, 6, 10, and 11, and the so called upstream conserved regions 1 and 2 (UCR1 and UCR2) found in PDE4.
Localization (found) of PDE4
3) Confidence 0.39 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0 Pain Relevance 0
An example of the importance of subcellular localization of PDE4 isoforms is their location in airway epithelial cells where it has been shown that they confine cAMP generated by apical adenosine A2B receptors to a microdomain that includes the target CFTR channels and prevents a rise in total cellular cAMP levels (Barnes et al 2005).
Localization (localization) of PDE4 in epithelial cells associated with adenocard
4) Confidence 0.37 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0 Pain Relevance 0.05
Unfortunately the use of rolipram was limited by significant side effects: particularly nausea, vomiting and gastric acid secretion (Horowski and Sastre-Y-Hernandez 1985) due to inhibition of PDE4 in the CNS and gastric parietal glands.
Localization (secretion) of PDE4 in glands associated with vomiting
5) Confidence 0.37 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0.69 Pain Relevance 0.08

General Comments

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