INT103319

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.45
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 8.37
Pain Relevance 5.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) transport (Trpv1) plasma membrane (Trpv1)
transmembrane transport (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
adipose tissue 6
neurons 4
liver 2
cell body 2
nociceptors 2
Trpv1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 151 100.00 Very High Very High Very High
nociceptor 22 100.00 Very High Very High Very High
ASIC 2 100.00 Very High Very High Very High
nMDA receptor 1 99.80 Very High Very High Very High
Glutamate 12 99.20 Very High Very High Very High
Thermal hyperalgesia 52 98.56 Very High Very High Very High
allodynia 18 97.12 Very High Very High Very High
gABA 6 96.08 Very High Very High Very High
dorsal root ganglion 102 94.96 High High
Dorsal horn 2 93.96 High High
Disease Link Frequency Relevance Heat
Obesity 52 99.30 Very High Very High Very High
Hyperalgesia 104 98.56 Very High Very High Very High
Nociception 48 98.40 Very High Very High Very High
Neuropathic Pain 56 97.12 Very High Very High Very High
Insulin Resistance 16 96.84 Very High Very High Very High
Ganglion Cysts 146 94.96 High High
INFLAMMATION 78 92.68 High High
Impaired Glucose Tolerance 16 89.04 High High
Nervous System Injury 16 87.84 High High
Non-diabetic Peripheral Neuropathy 20 75.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These effects are related to the activation of ASICs, TRPV1 and NMDA receptors, inhibition of the synthesis of prostanoids, and disruption of the C fibers.
Regulation (related) of Positive_regulation (activation) of TRPV1 associated with nmda receptor and asic
1) Confidence 0.45 Published 2010 Journal J Pain Section Abstract Doc Link 20338819 Disease Relevance 0.82 Pain Relevance 0.74
This transcription-independent mechanism of TRPV1 upregulation is found to be dependent on retrograde transport of NGF acting via p38 to increase TRPV1 translation in the cell body which results in increased transport of TRPV1 to peripheral terminals [74].
Regulation (dependent) of Positive_regulation (upregulation) of TRPV1 in cell body
2) Confidence 0.45 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 0.94 Pain Relevance 0.82
By patch clamp recordings and correlative immunocytochemistry, we studied here the effect of 2 microM capsaicin-induced vanilloid receptor-1 (TRPV1) activation on IPSCs in spinal lamina II neurons from post-natal mice.
Regulation (effect) of Positive_regulation (activation) of TRPV1 in neurons associated with qutenza
3) Confidence 0.45 Published 2007 Journal Pain Section Abstract Doc Link 17317009 Disease Relevance 0 Pain Relevance 0.44
By patch clamp recordings and correlative immunocytochemistry, we studied here the effect of 2 microM capsaicin-induced vanilloid receptor-1 (TRPV1) activation on IPSCs in spinal lamina II neurons from post-natal mice.
Regulation (effect) of Positive_regulation (activation) of vanilloid receptor-1 in neurons associated with qutenza
4) Confidence 0.45 Published 2007 Journal Pain Section Abstract Doc Link 17317009 Disease Relevance 0 Pain Relevance 0.44
On the other hand, the temperature threshold for TRPV1 activation was not changed upon treatment with a mixture of FSK, IBMX and dbcAMP in HEK293 cells expressing TRPV1 (40.8 ± 0.8°C, n = 4), suggesting different actions on TRPV1 by PKA and PKC.
Regulation (threshold) of Positive_regulation (activation) of TRPV1
5) Confidence 0.44 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0 Pain Relevance 0.24
antibody, supporting the TRPV1 activation pathway through PKC?
Regulation (through) of Positive_regulation (activation) of TRPV1
6) Confidence 0.44 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0.57 Pain Relevance 0.61
We also illustrate that up-regulation of TRPV1 and TRPA1 mRNA reflects increases in TRPV1 and TRPA1 responsiveness in the nociceptors that contribute to the molecular mechanisms of the thermal hyperalgesia and mechanical allodynia observed in cisplatin-treated mice.
Regulation (contribute) of Positive_regulation (increases) of TRPV1 in nociceptors associated with allodynia, thermal hyperalgesia and nociceptor
7) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 0.93 Pain Relevance 0.68
The effects of capsaicin in adipose tissue and liver are related to its dual action on PPARalpha and TRPV-1 expression/activation.
Regulation (action) of Positive_regulation (expression) of TRPV-1 in adipose tissue associated with qutenza and obesity
8) Confidence 0.17 Published 2010 Journal Obesity (Silver Spring) Section Abstract Doc Link 19798065 Disease Relevance 1.28 Pain Relevance 0.48
The effects of capsaicin in adipose tissue and liver are related to its dual action on PPARalpha and TRPV-1 expression/activation.
Regulation (action) of Positive_regulation (activation) of TRPV-1 in adipose tissue associated with qutenza and obesity
9) Confidence 0.17 Published 2010 Journal Obesity (Silver Spring) Section Abstract Doc Link 19798065 Disease Relevance 1.28 Pain Relevance 0.48
The effects of capsaicin in adipose tissue and liver are related to its dual action on PPARalpha and TRPV-1 expression/activation.
Regulation (action) of in liver Positive_regulation (activation) of TRPV-1 in adipose tissue associated with qutenza and obesity
10) Confidence 0.06 Published 2010 Journal Obesity (Silver Spring) Section Abstract Doc Link 19798065 Disease Relevance 1.28 Pain Relevance 0.48
The effects of capsaicin in adipose tissue and liver are related to its dual action on PPARalpha and TRPV-1 expression/activation.
Regulation (action) of in liver Positive_regulation (expression) of TRPV-1 in adipose tissue associated with qutenza and obesity
11) Confidence 0.06 Published 2010 Journal Obesity (Silver Spring) Section Abstract Doc Link 19798065 Disease Relevance 1.28 Pain Relevance 0.48
However, 45Ca2+ uptake was not detected after thapsigargin treatment, indicating that the emptying of the thapsigargin sensitive intracellular pools of Ca2+ was responsible for the elevated [Ca2+]i level rather than the activation of VR-1.
Regulation (responsible) of Positive_regulation (activation) of VR-1
12) Confidence 0.02 Published 2002 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 12054538 Disease Relevance 0 Pain Relevance 0.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox