INT103330

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Context Info
Confidence 0.28
First Reported 2002
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.27
Pain Relevance 2.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ngf, Gdnf) extracellular region (Ngf, Gdnf) cell proliferation (Gdnf)
signal transduction (Ngf) aging (Ngf) molecular_function (Ngf)
Anatomy Link Frequency
neurons 1
nerve 1
Ngf (Rattus norvegicus)
Gdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 205 100.00 Very High Very High Very High
Calcitonin gene-related peptide 192 100.00 Very High Very High Very High
trigeminal ganglion 118 99.24 Very High Very High Very High
dorsal root ganglion 28 99.04 Very High Very High Very High
qutenza 106 98.12 Very High Very High Very High
nociceptor 14 97.60 Very High Very High Very High
calcitonin gene related peptide 3 83.12 Quite High
substance P 11 80.84 Quite High
Inflammation 12 80.16 Quite High
Neuropeptide 22 50.00 Quite Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 150 99.24 Very High Very High Very High
Nociception 19 94.72 High High
INFLAMMATION 10 80.16 Quite High
Injury 46 5.00 Very Low Very Low Very Low
Hyperalgesia 14 5.00 Very Low Very Low Very Low
Headache 12 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low
Nervous System Injury 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both NGF and GDNF increased CGRP content concentration-dependently at every concentration (p < 0.001), with peaks at 10 ng/ml (3.2-fold increase) for NGF and 100 ng/ml (3.0-fold increase) for GDNF (Fig. 6C).
NGF Positive_regulation (increased) of GDNF associated with nerve growth factor and calcitonin gene-related peptide
1) Confidence 0.28 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0 Pain Relevance 0.88
NGF and GDNF each increased TRPV1 protein, and both upregulated the CGRP content of TG neurons.
NGF Positive_regulation (increased) of GDNF in neurons associated with nerve growth factor, trigeminal ganglion and calcitonin gene-related peptide
2) Confidence 0.26 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.70 Pain Relevance 0.77
Cells in population 1 can be regulated by glial cell line derived neurotrophic factor (GDNF) and those in populations 2 and 3 by nerve growth factor (NGF).
NGF Positive_regulation (derived) of GDNF in nerve associated with nerve growth factor
3) Confidence 0.01 Published 2002 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 12056559 Disease Relevance 0.57 Pain Relevance 0.81

General Comments

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