INT103332

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Context Info
Confidence 0.09
First Reported 2002
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.60
Pain Relevance 2.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (TRPV1) aging (Ngf) lipid metabolic process (TRPV1)
cytosol (TRPV1) extracellular space (Ngf) signal transduction (Ngf)
Anatomy Link Frequency
nerve 2
DRG 2
Ngf (Rattus norvegicus)
TRPV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 10 100.00 Very High Very High Very High
Thermal hyperalgesia 8 100.00 Very High Very High Very High
Inflammation 1 100.00 Very High Very High Very High
dorsal root ganglion 4 99.44 Very High Very High Very High
Eae 9 97.88 Very High Very High Very High
Paroxysmal extreme pain disorder 2 94.08 High High
qutenza 3 91.92 High High
Pain 2 90.08 High High
nociceptor 2 85.16 High High
Neuropathic pain 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 9 100.00 Very High Very High Very High
INFLAMMATION 1 100.00 Very High Very High Very High
Ganglion Cysts 4 99.44 Very High Very High Very High
Injury 9 97.88 Very High Very High Very High
Somatoform Disorder 2 92.56 High High
Pain 2 90.08 High High
Nociception 5 82.28 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

5 80.36 Quite High
Neuropathic Pain 2 75.00 Quite High
Incontinence 1 50.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The cause of this increase remains uncertain, but may be due to increase of nerve growth factor (NGF), which regulates the expression of both Na(v)1.7 and TRPV1, which we have previously reported to be increased in this condition.
NGF Regulation (regulates) of Gene_expression (expression) of TRPV1 in nerve associated with nerve growth factor
1) Confidence 0.09 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17928139 Disease Relevance 0.45 Pain Relevance 0.58
In vitro, DRG cells also show a range of VR1 expression levels that is NGF and (or) GDNF dependent.
NGF Regulation (dependent) of Gene_expression (expression) of VR1 in DRG associated with dorsal root ganglion and nerve growth factor
2) Confidence 0.05 Published 2002 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 12056559 Disease Relevance 0.53 Pain Relevance 0.77
In conclusion, although NGF drives inflammation-associated thermal hyperalgesia via its regulation of TRPV1 expression, NT-3 is now identified as a potent negative modulator of this state.
NGF Regulation (regulation) of Gene_expression (expression) of TRPV1 associated with inflammation, nerve growth factor and thermal hyperalgesia
3) Confidence 0.03 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15659614 Disease Relevance 1.35 Pain Relevance 1.05

General Comments

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