INT103350

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Context Info
Confidence 0.67
First Reported 2002
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 15
Total Number 17
Disease Relevance 9.77
Pain Relevance 3.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (DNMT1) DNA binding (DNMT1) transcription factor binding (DNMT1)
Anatomy Link Frequency
band 1
fibroblasts 1
pancreatic duct 1
neural 1
DNMT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 48 100.00 Very High Very High Very High
Central nervous system 42 100.00 Very High Very High Very High
endometriosis 187 99.68 Very High Very High Very High
rheumatoid arthritis 44 99.34 Very High Very High Very High
methotrexate 28 98.58 Very High Very High Very High
abatacept 123 98.22 Very High Very High Very High
Inflammation 71 97.60 Very High Very High Very High
metalloproteinase 26 90.80 High High
Chronic pancreatitis 6 90.08 High High
cINOD 10 84.80 Quite High
Disease Link Frequency Relevance Heat
Myelodysplastic Syndromes 174 99.84 Very High Very High Very High
Injury 6 99.76 Very High Very High Very High
Endometriosis 262 99.68 Very High Very High Very High
Targeted Disruption 4 99.66 Very High Very High Very High
Myeloid Leukemia 138 99.52 Very High Very High Very High
Cancer 399 99.38 Very High Very High Very High
Infection 33 99.36 Very High Very High Very High
Rheumatoid Arthritis 47 99.34 Very High Very High Very High
Repression 10 98.08 Very High Very High Very High
INFLAMMATION 87 97.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our previous studies using microdissection and immunohistochemistry revealed accumulation of DNA hypermethylation of tumor-related genes associated with DNMT1 overexpression, even in peripheral pancreatic duct epithelia at the precancerous stage [9, 10].
Gene_expression (overexpression) of DNMT1 in pancreatic duct associated with cancer
1) Confidence 0.67 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3010700 Disease Relevance 0.68 Pain Relevance 0.09
OBJECTIVE AND METHOD: Retrospective analysis of d-PTCA in AIM made during the annual period from Jan. 1 2000 to Dec. 31 2000.
Gene_expression (made) of AIM
2) Confidence 0.58 Published 2002 Journal Vnitr Lek Section Body Doc Link 12061202 Disease Relevance 0.27 Pain Relevance 0
This is the first report to show that NS398 can inhibit the expression of DNMT1 and 3b.
Gene_expression (expression) of DNMT1
3) Confidence 0.56 Published 2008 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 18367635 Disease Relevance 0.45 Pain Relevance 0.48
The average number of methylated tumor-related genes and the incidence of DNMT1 overexpression increase progressively with the progression of another precancerous lesion, pancreatic intraductal neoplasia [12], to well-differentiated ductal adenocarcinoma, and finally to poorly differentiated ductal adenocarcinoma, suggesting that DNA methylation alterations participate in multistage pancreatic carcinogenesis [9, 10].
Gene_expression (overexpression) of DNMT1 associated with adenocarcinoma and cancer
4) Confidence 0.52 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3010700 Disease Relevance 1.23 Pain Relevance 0.09
Contrariwise, other authors have reported that hydralazine decreases DNA methyltransferase 1 and 3a expression in a similar manner to PD98059, a Mitogen-activated protein kinase kinase (MEK) inhibitor, this suggesting that hydralazine does not directly inhibit DNA methyltransferase enzymatic activity [173].
Gene_expression (expression) of DNA methyltransferase 1
5) Confidence 0.40 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.91 Pain Relevance 0.12
This agent was able to inhibit DNMT1 expression without effecting DNMT3, causing demethylation with reexpression of silenced genes in cancer cell lines and tumor growth inhibition in mouse models.
Gene_expression (expression) of DNMT1 associated with cancer
6) Confidence 0.37 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 0.36 Pain Relevance 0
Accordingly, it has been shown that DNMT1 and DNMT3A are overexpressed in MDS and AML samples, when compared to controls [42].
Gene_expression (overexpressed) of DNMT1 associated with myeloid leukemia and myelodysplastic syndromes
7) Confidence 0.37 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 1.13 Pain Relevance 0
OPCML-v1 could also be induced in the colorectal cancer cell line HCT116 which is completely methylated for this gene, by genetic demethylation through double knock-out of both DNA methyltransferases DNMT1 and DNMT3B (DKO cell line) [25] (Fig. 4B).
Gene_expression (methyltransferases) of DNMT1 associated with targeted disruption and colon cancer
8) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 0.64 Pain Relevance 0
In this way, DNMT1 is no more available to remethylate hemi-methylated sites created during DNA replication, and methylation is passively lost in one of the daughter DNA molecules during cell division, inducing re-expression of gene silenced by promoter hypermethylation [59].
Gene_expression (expression) of DNMT1
9) Confidence 0.32 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 0.41 Pain Relevance 0
C-fos transformation of rat fibroblasts induces the expression of DNA 5-methylcytosine transferase (dnmt1), which causes hypermethylation and subsequent repression of gene expression by promoting the condensation of chromatin [134-136].
Gene_expression (expression) of dnmt1 in fibroblasts associated with repression
10) Confidence 0.25 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775067 Disease Relevance 0.78 Pain Relevance 0.18
The aim of this study was to determine the TNF-alpha and IL-6
Gene_expression (The) of aim
11) Confidence 0.23 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804300 Disease Relevance 0.67 Pain Relevance 0.32
The aim of this study was to determine the TNF-alpha and IL-6
Spec (determine) Gene_expression (determine) of aim
12) Confidence 0.23 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804300 Disease Relevance 0.66 Pain Relevance 0.32
We propose that up-regulation and activity of c-fos seen in the baboon model of endometriosis may induce the expression of dnmt1 and subsequent hypermethylation and down-regulation of endometrial HOXA10 and other progesterone-regulated genes.


Gene_expression (expression) of dnmt1 associated with endometriosis
13) Confidence 0.19 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775067 Disease Relevance 0.72 Pain Relevance 0.30
Here we found a 3-fold greater expression level for DNMT-1 in R2 from older compared to younger animals, further suggesting that DNA methylation transcriptional repression might play an important role in the control of genome-wide chromatin reorganization in aging.
Gene_expression (expression) of DNMT-1 associated with aging and repression
14) Confidence 0.12 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2910937 Disease Relevance 0.24 Pain Relevance 0.03
Finally, our pilot in situ hybridization data indicate differential expression in the CNS of Aplysia DNMT1 (not shown, Kohn et al., 2009), suggesting that the tonic level of DNA methylation can also be an important mechanism for controlling cellular phenotypes in neural circuits.
Gene_expression (expression) of DNMT1 in neural associated with central nervous system
15) Confidence 0.09 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2910937 Disease Relevance 0.26 Pain Relevance 0.05
Abatacept plus methotrexate in patients with rheumatoid arthritis and a history of DMARD failure (AIM study)
Gene_expression (study) of AIM associated with rheumatoid arthritis, abatacept and methotrexate
16) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582812 Disease Relevance 0.35 Pain Relevance 1.63
A single band (34 kDa) corresponding to ApoE was present only in the Dex and AIM treated MSCs (Figure 2b).
Gene_expression (present) of AIM in band associated with dexamethasone
17) Confidence 0.02 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2596794 Disease Relevance 0 Pain Relevance 0.24

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