INT103360

Context Info Confidence 0.50 First Reported 2002 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.07 Pain Relevance 0.45

cell differentiation (Lbx1) nucleus (Lbx1) DNA binding (Lbx1)

Anatomy Link Frequency dorsal 1 substantia gelatinosa 1 Lbx1 (Mus musculus)

Pain Link Frequency Relevance Heat interneuron 1 97.88 substantia gelatinosa 3 95.48 Spinal cord 5 92.16 Dorsal horn 2 78.64 Pain 2 66.88 nociceptor 3 25.00 Central nervous system 1 5.00 Dorsal horn neuron 1 5.00

Disease Link Frequency Relevance Heat Pain 2 66.88 Targeted Disruption 6 5.00 Apoptosis 2 5.00 Acquired Immune Deficiency Syndrome Or Hiv Infection 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Lbx1 is expressed in and required for the correct specification of three early dorsal interneuron populations and late-born neurons that form the substantia gelatinosa.

Positive_regulation (required) of Lbx1 in substantia gelatinosa associated with substantia gelatinosa and interneuron

1) Confidence 0.50 Published 2002 Journal Neuron Section Abstract Doc Link 12062038 Disease Relevance 0 Pain Relevance 0.34

The significant increase in the expression levels of these Hox genes in Lbx1 mutants indicates that Lbx1 represses the expression of these Hox genes in at least some dorsal cell populations.

Positive_regulation (increase) of Lbx1 in dorsal

2) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527684 Disease Relevance 0.07 Pain Relevance 0.11

General Comments

This test has worked.