INT103360

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Context Info
Confidence 0.50
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.07
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Lbx1) nucleus (Lbx1) DNA binding (Lbx1)
Anatomy Link Frequency
dorsal 1
substantia gelatinosa 1
Lbx1 (Mus musculus)
Pain Link Frequency Relevance Heat
interneuron 1 97.88 Very High Very High Very High
substantia gelatinosa 3 95.48 Very High Very High Very High
Spinal cord 5 92.16 High High
Dorsal horn 2 78.64 Quite High
Pain 2 66.88 Quite High
nociceptor 3 25.00 Low Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Dorsal horn neuron 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 2 66.88 Quite High
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lbx1 is expressed in and required for the correct specification of three early dorsal interneuron populations and late-born neurons that form the substantia gelatinosa.
Positive_regulation (required) of Lbx1 in substantia gelatinosa associated with substantia gelatinosa and interneuron
1) Confidence 0.50 Published 2002 Journal Neuron Section Abstract Doc Link 12062038 Disease Relevance 0 Pain Relevance 0.34
The significant increase in the expression levels of these Hox genes in Lbx1 mutants indicates that Lbx1 represses the expression of these Hox genes in at least some dorsal cell populations.
Positive_regulation (increase) of Lbx1 in dorsal
2) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527684 Disease Relevance 0.07 Pain Relevance 0.11

General Comments

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