INT103361

Context Info Confidence 0.57 First Reported 2002 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 3 Disease Relevance 0 Pain Relevance 0.37

cell differentiation (Lbx1) nucleus (Lbx1) DNA binding (Lbx1)

Anatomy Link Frequency dorsal 1 Lbx1 (Mus musculus)

Pain Link Frequency Relevance Heat substantia gelatinosa 5 99.60 interneuron 1 96.80 Dorsal horn 2 91.12 Spinal cord 7 85.08 Pain 3 71.04 nociceptor 3 25.00 Central nervous system 2 5.00 Dorsal horn neuron 2 5.00

Disease Link Frequency Relevance Heat Apoptosis 4 48.24 Targeted Disruption 12 19.24 Pain 3 5.00 Acquired Immune Deficiency Syndrome Or Hiv Infection 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Third, loss of Lbx1 function leads to known changes in SSTF expression that provide positive controls for the analysis [9], [30].

Negative_regulation (loss) of Lbx1

1) Confidence 0.57 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527684 Disease Relevance 0 Pain Relevance 0

The homeodomain transcription factor Lbx1 is expressed in five such populations and loss of Lbx1 leads to distinct respecifications in each of the five populations.

Negative_regulation (loss) of Lbx1

2) Confidence 0.57 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2527684 Disease Relevance 0 Pain Relevance 0

In mice lacking Lbx1, cells types that arise in the ventral alar plate acquire more dorsal identities.

Negative_regulation (lacking) of Lbx1 in dorsal

3) Confidence 0.43 Published 2002 Journal Neuron Section Abstract Doc Link 12062038 Disease Relevance 0 Pain Relevance 0.37

General Comments

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