INT103378

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Context Info
Confidence 0.40
First Reported 2001
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 24
Total Number 26
Disease Relevance 15.30
Pain Relevance 6.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Spink1)
Spink1 (Rattus norvegicus)
Spink1 - N34S (5)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 109 100.00 Very High Very High Very High
fibrosis 38 100.00 Very High Very High Very High
Pain 1 95.52 Very High Very High Very High
alcohol 4 95.28 Very High Very High Very High
abdominal pain 3 85.20 High High
Inflammation 11 35.12 Quite Low
nud 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 285 100.00 Very High Very High Very High
Cystic Fibrosis 12 100.00 Very High Very High Very High
Diabetes Mellitus 85 99.76 Very High Very High Very High
Calcification 21 99.56 Very High Very High Very High
Disease 26 96.84 Very High Very High Very High
Pain 1 95.52 Very High Very High Very High
Exocrine Pancreatic Insufficiency 1 94.92 High High
Fibrosis 28 93.60 High High
Ascariasis 1 91.48 High High
Protein-energy Malnutrition 1 91.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the association of SPINK1 mutations with alcoholic CP is still controversial.
SPINK1 Binding (association) of associated with chronic pancreatitis
1) Confidence 0.40 Published 2004 Journal Korean J Gastroenterol Section Abstract Doc Link 15329520 Disease Relevance 0.64 Pain Relevance 0.54
BACKGROUND: The SPINK1 mutation N34S is associated to chronic pancreatitis of idiopathic, alcoholic and tropic origin.
SPINK1 (N34S) Binding (associated) of associated with chronic pancreatitis
2) Confidence 0.36 Published 2003 Journal Pancreatology Section Abstract Doc Link 12649567 Disease Relevance 0.25 Pain Relevance 0.10
CONCLUSION: The SPINK1-N34S mutation is not associated with chronic parotitis.


SPINK1 (N34S) Binding (associated) of
3) Confidence 0.36 Published 2004 Journal Dig Dis Section Body Doc Link 15753612 Disease Relevance 0.08 Pain Relevance 0
The SPINK1 N34S mutation is not associated with Type 2 diabetes mellitus in a population of the USA.
SPINK1 (N34S) Binding (associated) of associated with diabetes mellitus
4) Confidence 0.36 Published 2005 Journal Diabet. Med. Section Title Doc Link 15910626 Disease Relevance 0.28 Pain Relevance 0.09
Recently, an association of SPINK1 mutations with early-onset Type 2 diabetes mellitus has been reported in patients from Bangladesh.
SPINK1 Binding (association) of associated with diabetes mellitus
5) Confidence 0.36 Published 2005 Journal Diabet. Med. Section Abstract Doc Link 15910626 Disease Relevance 0.27 Pain Relevance 0.10
The possible interaction of mutations in the SPINK1 gene with other pancreatitis-associated susceptibility genes has to be investigated in future research efforts.
SPINK1 gene Binding (interaction) of associated with pancreatitis
6) Confidence 0.35 Published 2004 Journal Gastroenterol. Clin. North Am. Section Abstract Doc Link 15528018 Disease Relevance 0.83 Pain Relevance 0.47
This suggests that there is no interaction between the I/D variant in the ACE gene and the N34S mutation in the SPINK1 gene in either TCP or FCPD patients.
SPINK1 (N34S) Neg (no) Binding (interaction) of associated with diabetes mellitus and pancreatitis
7) Confidence 0.35 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1762011 Disease Relevance 0.84 Pain Relevance 0
Since SPINK1 mutations are proposed a modifier role, we also investigated its interaction with the ACE gene variant.


SPINK1 Binding (interaction) of
8) Confidence 0.34 Published 2006 Journal BMC Gastroenterol Section Abstract Doc Link PMC1762011 Disease Relevance 1.39 Pain Relevance 0.05
An association with gene mutations (PRSS1, SPINK1, CTFR-5T genotype) is suspected.
SPINK1 Binding (association) of
9) Confidence 0.32 Published 2002 Journal Dig. Dis. Sci. Section Abstract Doc Link 12064796 Disease Relevance 1.22 Pain Relevance 0.43
CONCLUSIONS: We conclude that SPINK1 mutations are associated with FCPD in Bangladesh.
SPINK1 Binding (associated) of
10) Confidence 0.31 Published 2001 Journal Pancreatology Section Body Doc Link 12120202 Disease Relevance 0.08 Pain Relevance 0
Mutations and polymorphisms in the SPINK1 gene, which encodes trypsin's physiological inhibitor, pancreatic secretory trypsin inhibitor, have been found to be associated with chronic pancreatitis.
SPINK1 Binding (associated) of associated with chronic pancreatitis
11) Confidence 0.31 Published 2006 Journal Eur. J. Hum. Genet. Section Abstract Doc Link 16823394 Disease Relevance 0.23 Pain Relevance 0.18
Mutations of three major genes are associated with an increased risk of acute and chronic pancreatitis: the cationic trypsinogen (PRSS1) gene, the cystic fibrosis transmembrane conductance regulator (CFTR) gene, and the pancreatic secretory trypsin inhibitor (PSTI) or serine protease inhibitor, Kazal type 1 (SPINK1) gene.
SPINK1 Binding (associated) of associated with fibrosis, cystic fibrosis and chronic pancreatitis
12) Confidence 0.30 Published 2003 Journal Can. J. Gastroenterol. Section Abstract Doc Link 12560855 Disease Relevance 0.66 Pain Relevance 0.31
Mutations of three major genes are associated with an increased risk of acute and chronic pancreatitis: the cationic trypsinogen (PRSS1) gene, the cystic fibrosis transmembrane conductance regulator (CFTR) gene, and the pancreatic secretory trypsin inhibitor (PSTI) or serine protease inhibitor, Kazal type 1 (SPINK1) gene.
PSTI Binding (associated) of associated with fibrosis, cystic fibrosis and chronic pancreatitis
13) Confidence 0.30 Published 2003 Journal Can. J. Gastroenterol. Section Abstract Doc Link 12560855 Disease Relevance 0.58 Pain Relevance 0.30
SPINK1 N34S is strongly associated with recurrent acute pancreatitis but is not a risk factor for the first or sentinel acute pancreatitis event.
SPINK1 N34S (N34S) Binding (associated) of associated with pancreatitis
14) Confidence 0.29 Published 2010 Journal Am. J. Gastroenterol. Section Title Doc Link 19888199 Disease Relevance 0.29 Pain Relevance 0.09
In 2000, Witt et al. first recognized the association between mutations in the SPINK1 gene and chronic pancreatitis (CP), but the significance of SPINK1 gene mutation in pancreatitis and its relation to alcohol consumption remains unclear in Japan.
SPINK1 Binding (association) of associated with pancreatitis, chronic pancreatitis and alcohol
15) Confidence 0.28 Published 2006 Journal J. Gastroenterol. Hepatol. Section Abstract Doc Link 16958672 Disease Relevance 0.51 Pain Relevance 0.46
The strong association of mutations in the PRSS1 gene and in the SPINK1 gene with chronic pancreatitis supports the concept of intracellular trypsin activation as an initiating and extremely important step in the development of pancreatitis.
SPINK1 gene Binding (association) of associated with pancreatitis and chronic pancreatitis
16) Confidence 0.27 Published 2004 Journal Gastroenterol. Clin. North Am. Section Abstract Doc Link 15528018 Disease Relevance 0.73 Pain Relevance 0.42
SPINK1 mutations are associated with the development of acute and chronic pancreatitis and have been detected in all forms of chronic pancreatitis.
SPINK1 Binding (associated) of associated with chronic pancreatitis
17) Confidence 0.26 Published 2004 Journal Gastroenterol. Clin. North Am. Section Abstract Doc Link 15528018 Disease Relevance 0.54 Pain Relevance 0.33
The possible interaction of mutations in the SPINK1 gene with other pancreatitis-associated susceptibility genes has to be investigated in future research efforts.
SPINK1 gene Binding (interaction) of associated with pancreatitis
18) Confidence 0.26 Published 2005 Journal Clin. Lab. Med. Section Abstract Doc Link 15749232 Disease Relevance 0.83 Pain Relevance 0.47
Strong associations of SPINK1 mutation and different forms of pancreatitis were suggested.
SPINK1 Binding (associations) of associated with pancreatitis
19) Confidence 0.22 Published 2007 Journal Korean J Gastroenterol Section Abstract Doc Link 17641557 Disease Relevance 0.67 Pain Relevance 0.33
Tropical calcific pancreatitis: strong association with SPINK1 trypsin inhibitor mutations.
SPINK1 Binding (association) of associated with calcification and pancreatitis
20) Confidence 0.22 Published 2002 Journal Gastroenterology Section Title Doc Link 12360463 Disease Relevance 0.95 Pain Relevance 0.10

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