INT103399

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.66
First Reported 2002
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 7.00
Pain Relevance 7.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pparg) signal transduction (Pparg) nucleus (Pparg)
enzyme binding (Pparg) DNA binding (Pparg) cytoplasm (Pparg)
Anatomy Link Frequency
neurons 6
SW480 2
synovial cells 2
RAW 264 2
astrocytes 2
Pparg (Mus musculus)
Pain Link Frequency Relevance Heat
noradrenaline 32 99.98 Very High Very High Very High
aspirin 3 99.98 Very High Very High Very High
qutenza 21 99.84 Very High Very High Very High
COX-2 inhibitor 8 99.82 Very High Very High Very High
Inflammation 30 99.44 Very High Very High Very High
cINOD 25 99.36 Very High Very High Very High
antagonist 10 93.12 High High
Locus ceruleus 12 85.00 Quite High
agonist 7 84.48 Quite High
Paracetamol 1 79.68 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 13 99.96 Very High Very High Very High
Colon Cancer 2 99.60 Very High Very High Very High
INFLAMMATION 43 99.44 Very High Very High Very High
Obesity 13 94.72 High High
Disease 24 89.00 High High
Increased Venous Pressure Under Development 1 81.24 Quite High
Diabetes Mellitus 1 80.44 Quite High
Death 5 77.44 Quite High
Cancer 14 75.52 Quite High
Necrosis 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Luciferase reporter assay demonstrated that not only PPARgamma ligands but also NSAIDs, which could induce apoptosis, increased the activation of PPARgamma in synovial cells.
Positive_regulation (increased) of Positive_regulation (activation) of PPARgamma in synovial cells associated with cinod and apoptosis
1) Confidence 0.66 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12065695 Disease Relevance 0.76 Pain Relevance 0.53
Incubation of astrocytes and neurons with 100 micro m NA resulted in an increase of PPARgamma mRNA as well as PPARgamma protein levels in both cell types.
Positive_regulation (resulted) of Positive_regulation (increase) of PPARgamma in neurons associated with noradrenaline
2) Confidence 0.50 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12887689 Disease Relevance 0.86 Pain Relevance 0.91
1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes containing p-trifluoromethyl, t-butyl, and phenyl [1,1-bis(3'-indolyl)-1-(p-phenyl)methane (DIM-C-pPhC(6)H(5))] substituents induce peroxisome proliferator-activated receptor gamma (PPARgamma)-mediated transactivation in SW480 colon cancer cells.
Positive_regulation (induce) of Positive_regulation (transactivation) of PPARgamma in SW480 associated with colon cancer
3) Confidence 0.50 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16731770 Disease Relevance 0.31 Pain Relevance 0.08
Our data demonstrate for the first time that the anti-inflammatory action of capsaicin may be mediated by PPARgamma activation in LPS-stimulated RAW 264.7 cells.
Positive_regulation (mediated) of Positive_regulation (activation) of PPARgamma in RAW 264 associated with qutenza and inflammation
4) Confidence 0.48 Published 2004 Journal FEBS Lett. Section Abstract Doc Link 15304360 Disease Relevance 0.48 Pain Relevance 1.16
Activation of PPARgamma by AJA requires the AF-2 helix of the receptor, suggesting that AJA activates PPARgamma through the ligand-dependent AF-2 function.
Positive_regulation (requires) of Positive_regulation (Activation) of PPARgamma
5) Confidence 0.47 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12695526 Disease Relevance 0.37 Pain Relevance 0.35
Incubation of astrocytes and neurons with 100 micro m NA resulted in an increase of PPARgamma mRNA as well as PPARgamma protein levels in both cell types.
Positive_regulation (resulted) of Positive_regulation (increase) of PPARgamma in neurons associated with noradrenaline
6) Confidence 0.47 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12887689 Disease Relevance 0.86 Pain Relevance 0.92
The action of capsaicin is associated with NF-kappaB inactivation and/or PPARgamma activation.
Positive_regulation (inactivation) of Positive_regulation (activation) of PPARgamma associated with qutenza
7) Confidence 0.46 Published 2007 Journal FEBS Lett. Section Abstract Doc Link 17719033 Disease Relevance 1.14 Pain Relevance 0.69
Some of the COX-independent mechanisms for NSAIDs and selective COX-2 inhibitors include activation of protein kinase G, inhibition of NF-kappa B activation, downregulation of the antiapoptotic protein Bcl-XL, inhibition of PPAR delta, and activation of PPAR gamma.
Positive_regulation (activation) of Positive_regulation (activation) of PPAR gamma associated with cinod and cox-2 inhibitor
8) Confidence 0.22 Published 2003 Journal Prog Exp Tumor Res Section Abstract Doc Link 12795055 Disease Relevance 0.50 Pain Relevance 0.55
Incubation of astrocytes and neurons with 100 micro m NA resulted in an increase of PPARgamma mRNA as well as PPARgamma protein levels in both cell types.
Positive_regulation (resulted) of in astrocytes Positive_regulation (increase) of PPARgamma in neurons associated with noradrenaline
9) Confidence 0.17 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12887689 Disease Relevance 0.86 Pain Relevance 0.91
Incubation of astrocytes and neurons with 100 micro m NA resulted in an increase of PPARgamma mRNA as well as PPARgamma protein levels in both cell types.
Positive_regulation (resulted) of in astrocytes Positive_regulation (increase) of PPARgamma in neurons associated with noradrenaline
10) Confidence 0.16 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12887689 Disease Relevance 0.86 Pain Relevance 0.92
These results suggest that indomethacin and aspirin upregulate gastric expression of TFF2 through activation of PPARgamma.
Positive_regulation (upregulate) of Positive_regulation (activation) of PPARgamma associated with aspirin
11) Confidence 0.15 Published 2004 Journal FEBS Lett. Section Abstract Doc Link 14759512 Disease Relevance 0 Pain Relevance 0.35

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox