INT103400

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Context Info
Confidence 0.67
First Reported 2002
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.15
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pparg) signal transduction (Pparg) nucleus (Pparg)
enzyme binding (Pparg) DNA binding (Pparg) cytoplasm (Pparg)
Anatomy Link Frequency
adipose tissue 2
synovial cells 1
Pparg (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 1 91.48 High High
Central nervous system 2 88.24 High High
diclofenac 1 85.72 High High
cINOD 8 80.96 Quite High
rheumatoid arthritis 1 64.88 Quite High
melanocortin 1 receptor 22 59.72 Quite High
COX2 1 25.00 Low Low
cOX1 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 10 98.88 Very High Very High Very High
Obesity 66 96.76 Very High Very High Very High
Targeted Disruption 138 96.12 Very High Very High Very High
Syndrome 14 91.76 High High
Death 1 89.24 High High
Hyperphagia 4 78.52 Quite High
Hyperinsulinism 14 78.00 Quite High
INFLAMMATION 2 75.00 Quite High
Rheumatoid Arthritis 1 64.88 Quite High
Hyperplasia 10 45.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transgenic mice with adipocyte-specific agouti expression were shown to have significantly increased fat mass compared to control mice, which was accompanied by an increase in the protein levels of three transcription factors (Pparg, peroxisome proliferator activated receptor gamma; Stat1, signal transducer and activator of transcription 1; and Stat3) in their adipose tissue [36].
Transcription (transcription) of Pparg in adipose tissue associated with targeted disruption and obesity
1) Confidence 0.67 Published 2004 Journal Mol Cancer Section Body Doc Link PMC443512 Disease Relevance 1.10 Pain Relevance 0.10
Rheumatoid synovial cells expressed PPARgamma mRNA, and the PPARgamma ligands 15-deoxy-Delta(12,14)-prostaglandin J(2) and troglitazone reduced the proliferation and induced apoptosis in synovial cells.
Transcription (expressed) of PPARgamma in synovial cells associated with apoptosis
2) Confidence 0.51 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12065695 Disease Relevance 0.92 Pain Relevance 0.64
Transgenic mice with adipocyte-specific agouti expression were shown to have significantly increased fat mass compared to control mice, which was accompanied by an increase in the protein levels of three transcription factors (Pparg, peroxisome proliferator activated receptor gamma; Stat1, signal transducer and activator of transcription 1; and Stat3) in their adipose tissue [36].
Transcription (transcription) of peroxisome proliferator activated receptor gamma in adipose tissue associated with targeted disruption and obesity
3) Confidence 0.46 Published 2004 Journal Mol Cancer Section Body Doc Link PMC443512 Disease Relevance 1.12 Pain Relevance 0.10

General Comments

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