INT103446

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Context Info
Confidence 0.39
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.21
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Krt10)
Anatomy Link Frequency
keratinocyte 1
I-10 1
Krt10 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 9 98.96 Very High Very High Very High
tolerance 1 92.68 High High
medulla 2 88.84 High High
Inflammatory mediators 6 72.72 Quite High
cINOD 3 69.04 Quite High
fibrosis 1 47.68 Quite Low
cOX1 1 25.00 Low Low
COX2 1 25.00 Low Low
Inflammation 42 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 54 99.22 Very High Very High Very High
INFLAMMATION 55 98.78 Very High Very High Very High
Infection 41 95.76 Very High Very High Very High
Metastasis 11 92.96 High High
Apoptosis 15 90.84 High High
Non-genital Cutaneous Warts 4 87.68 High High
Acanthosis 8 84.68 Quite High
Carcinoma 37 84.24 Quite High
Skin Diseases 5 79.32 Quite High
Congenital Anomalies 10 78.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
K10 expression started in the first suprabasal layer in mice of both genotypes, but the number of K10-positive layers was increased in K5-R1/R2 mice.
Gene_expression (expression) of K10
1) Confidence 0.39 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.78 Pain Relevance 0
The premature onset of keratinocyte terminal differentiation appeared to be the cellular event leading to the reduced tumorigenesis because keratin 1 and keratin 10, two keratins that indicate the commitment of keratinocytes to differentiate, were expressed 8-13-fold and 10-20-fold more frequently in epidermal basal cells of the COX-1-deficient and COX-2-deficient mice, respectively, than in wild-type mice.
Gene_expression (expressed) of keratin 10 in keratinocyte
2) Confidence 0.19 Published 2002 Journal Cancer Res. Section Abstract Doc Link 12067981 Disease Relevance 0.29 Pain Relevance 0.07
Immunocytochemically, tumor cells from all cases examined did not express keratin 10, while strong positivity to anti-keratin 5, 8, and 18 antibodies, and anti-UEL antibody was observed.
Neg (not) Gene_expression (express) of keratin 10 associated with cancer
3) Confidence 0.02 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 0.74 Pain Relevance 0.04
The gene expression pattern we observed here is indeed consistent with an effect of Cox-2 inhibition on the inflammatory response (See Figure 3 and Table 1) although the changes in expression of classical Th1/Th2 mediators such as IL-12, I-10 and IL-4 did not differ significantly in our study.
Gene_expression (expression) of I-10 in I-10 associated with inflammatory response
4) Confidence 0.01 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2667483 Disease Relevance 0.40 Pain Relevance 0.17

General Comments

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