INT103456

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Context Info
Confidence 0.49
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.85
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (SMPD2) plasma membrane (SMPD2)
Anatomy Link Frequency
SW480 1
epithelium 1
SMPD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 8 99.98 Very High Very High Very High
qutenza 2 89.20 High High
Inflammation 10 64.36 Quite High
cytokine 2 32.88 Quite Low
Crohn's disease 4 5.00 Very Low Very Low Very Low
Versed 2 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
tetrodotoxin 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 68 96.88 Very High Very High Very High
Stress 6 94.44 High High
Colitis 31 84.32 Quite High
Colon Cancer 43 74.08 Quite High
INFLAMMATION 10 64.36 Quite High
Reprotox - General 1 10 61.08 Quite High
Inflammatory Bowel Disease 17 53.08 Quite High
Recurrence 2 51.96 Quite High
Diarrhoea 7 47.52 Quite Low
Gastrointestinal Disease 4 26.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To evaluate secretory and absorptive function of the colonic epithelium, we measured the basal and forskolin-stimulated Isc (which is an assessment of the electrogenic anion secretion, and its stimulation by an increase in intracellular cAMP levels), as well as net Na+ absorption before and after an increase in cAMP levels.
Positive_regulation (stimulated) of Isc in epithelium
1) Confidence 0.49 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2110898 Disease Relevance 0.38 Pain Relevance 0.03
Next, native HT29 and SW480 cells were treated with increasing concentrations of ISC-4 and a viability assay was performed.
Positive_regulation (increasing) of ISC in SW480
2) Confidence 0.49 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.42 Pain Relevance 0
Serum-withdrawal activates neutral sphingomyelinase (N-SMase), ceramide release and caspase-3-related proteases.
Positive_regulation (activates) of N-SMase associated with withdrawal
3) Confidence 0.04 Published 2002 Journal Free Radic. Res. Section Abstract Doc Link 12069099 Disease Relevance 0.54 Pain Relevance 0.27
CoQ addition to serum-free cultures inhibited a 60% N-SMase activation, an 80% ceramide release, and a 50% caspase-3 activity induced by serum deprivation.
Positive_regulation (activation) of N-SMase
4) Confidence 0.03 Published 2002 Journal Free Radic. Res. Section Abstract Doc Link 12069099 Disease Relevance 0.50 Pain Relevance 0.25

General Comments

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