INT103463

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Context Info
Confidence 0.66
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 18
Disease Relevance 9.63
Pain Relevance 4.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 1
cerebrospinal fluid 1
pelvis 1
heart 1
CPP (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 821 100.00 Very High Very High Very High
pain pelvic 20 100.00 Very High Very High Very High
Pain 9 100.00 Very High Very High Very High
adenocard 2 100.00 Very High Very High Very High
Potency 4 98.96 Very High Very High Very High
Inflammation 10 98.52 Very High Very High Very High
interstitial cystitis 2 96.68 Very High Very High Very High
tetrodotoxin 1 93.92 High High
ischemia 20 81.64 Quite High
dexamethasone 3 70.20 Quite High
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 564 100.00 Very High Very High Very High
Reprotox - General 3 20 100.00 Very High Very High Very High
Pain 5 100.00 Very High Very High Very High
Injury 36 99.96 Very High Very High Very High
Sleep Disorders 21 99.90 Very High Very High Very High
Volume Depletion And Dehydration 5 98.72 Very High Very High Very High
INFLAMMATION 11 98.52 Very High Very High Very High
Cerebral Hypoxia 10 97.76 Very High Very High Very High
Bladder Disease 2 97.68 Very High Very High Very High
Interstitial Cystitis 2 96.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Though there are myriad etiologies of CPP, common therapeutic targets include inflammation, somatic dysfunction, and psychological disturbances.
Localization (etiologies) of CPP associated with inflammation
1) Confidence 0.66 Published 2010 Journal Altern Ther Health Med Section Abstract Doc Link 20085175 Disease Relevance 0.32 Pain Relevance 0.17
CONCLUSION: The CPP questionnaire can be considered as a validated tool for primary screening of CPP.


Localization (screening) of CPP
2) Confidence 0.65 Published 2002 Journal Eur. J. Obstet. Gynecol. Reprod. Biol. Section Body Doc Link 12069743 Disease Relevance 0 Pain Relevance 0
Despite the frequent occurrence of IC/PBS as a cause of CPP, there currently are no universally accepted guidelines for diagnosis and treatment of this disorder, and, consequently, many patients do not receive appropriate treatment in a timely manner.
Localization (cause) of CPP associated with pain pelvic
3) Confidence 0.65 Published 2009 Journal J Reprod Med Section Abstract Doc Link 19263874 Disease Relevance 0.87 Pain Relevance 0.87
With increased ICP or decreased CPP, StcO2 is reduced.
Localization (decreased) of CPP associated with cva
4) Confidence 0.61 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.63 Pain Relevance 0.56
They were divided in groups according to age, type of disease and presence of CPP.
Localization (presence) of CPP
5) Confidence 0.59 Published 2008 Journal Akush Ginekol (Sofiia) Section Body Doc Link 18642584 Disease Relevance 0.15 Pain Relevance 0
When there is no relationship between MAP and ICP, increasing MAP typically will not increase ICP [15,22,23] Thus, when the CAP Index is increased and ICP cannot be reduced, increasing MAP may improve CPP.
Localization (improve) of CPP associated with cva
6) Confidence 0.53 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.14 Pain Relevance 0.42
It was rendered an account of the beginning of CPP, its qualitative and quantitative characteristics, localization and irradiation, its dynamics according to menstrual cycle and day.
Localization (localization) of CPP
7) Confidence 0.37 Published 2005 Journal Akush Ginekol (Sofiia) Section Body Doc Link 16028396 Disease Relevance 0.07 Pain Relevance 0
In summary, after recognition and treatment of the origins of the patientÂ’s poor condition, additional factors associated with ischemic condition (increased ICP, decreased CPP, and damaged autoregulation) still need to be monitored.
Localization (decreased) of CPP associated with cva
8) Confidence 0.35 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350130 Disease Relevance 0.57 Pain Relevance 0.16
Following liver trauma, CPP and CO as well as NIRS and TCD values decreased continuously.
Localization (decreased) of CPP in liver associated with injury
9) Confidence 0.28 Published 2006 Journal Crit Care Section Body Doc Link PMC1550846 Disease Relevance 0.19 Pain Relevance 0
PC increased left ventricular end-diastolic pressure (LVEDP), coronary perfusion pressure (CPP), wall stiffness, and cardiac lactate and adenosine release from the isolated heart.
Localization (release) of CPP in heart associated with adenocard
10) Confidence 0.22 Published 2009 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19403851 Disease Relevance 0.07 Pain Relevance 0.18
The maximum CPP decrease (mean value of each group) was 4 mmHg, 8 mmHg, and 18 mmHg in groups 1, 2, and 3, respectively.
Localization (decrease) of CPP
11) Confidence 0.19 Published 2005 Journal Acta Anaesthesiol Scand Section Body Doc Link 15777290 Disease Relevance 0.12 Pain Relevance 0
Hyperosmolar therapy [128] should be used after sedation and CPP optimization fail to normalize ICP (Class IIA, Level of Evidence B).
Localization (optimization) of CPP associated with cva and sleep disorders
12) Confidence 0.12 Published 2008 Journal Crit Care Section Body Doc Link PMC2646334 Disease Relevance 0.72 Pain Relevance 0.23
If the postulated mechanisms seem to explain some aspects of CPP translocation and still appear to hold for peptides exhibiting lipid-binding capacity, it would seem unlikely that these mechanisms apply to highly hydrophilic CPPs (52).
Localization (translocation) of CPP
13) Confidence 0.11 Published 2008 Journal AAPS J Section Body Doc Link PMC2761699 Disease Relevance 0 Pain Relevance 0
This controversy, however, may reflect the possibility that different peptides utilize different uptake mechanisms depending on their cargo and biophysical properties, or that CPP membrane translocation is mediated by several different pathways that may occur simultaneously (47).
Localization (translocation) of CPP
14) Confidence 0.11 Published 2008 Journal AAPS J Section Body Doc Link PMC2761699 Disease Relevance 0 Pain Relevance 0
In fact, later studies have shown that CPP translocation is mostly a temperature-dependent process (53) and have established the possible role of endocytosis in the internalization of CPPs (52,54,55).
Localization (translocation) of CPP
15) Confidence 0.11 Published 2008 Journal AAPS J Section Body Doc Link PMC2761699 Disease Relevance 0 Pain Relevance 0
CPP is nonmenstrual pain localized in the anatomic pelvis of at least 6 months' duration without any identifiable organic cause that is severe enough to cause functional disability and require treatment.
Localization (localized) of CPP in pelvis associated with pain and pain pelvic
16) Confidence 0.09 Published 2009 Journal Clin Imaging Section Abstract Doc Link 19559354 Disease Relevance 0.87 Pain Relevance 0.55
Therefore, it can be concluded that local cerebral dehydration is the main mechanism of both substances in decreasing ICP and optimizing CPP.
Localization (optimizing) of CPP associated with volume depletion and dehydration and cva
17) Confidence 0.08 Published 2005 Journal Crit Care Section Body Doc Link PMC1297608 Disease Relevance 0.91 Pain Relevance 0.29
This technique allows for rapid clearance of cerebrospinal fluid, release of ICP, and ICP/CPP monitoring.
Localization (release) of CPP in cerebrospinal fluid associated with cva
18) Confidence 0.06 Published 2008 Journal Crit Care Section Body Doc Link PMC2646334 Disease Relevance 1.99 Pain Relevance 0.64

General Comments

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