INT103469

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Context Info
Confidence 0.67
First Reported 2001
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 59
Total Number 59
Disease Relevance 24.39
Pain Relevance 18.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (BDNF) cytoplasmic membrane-bounded vesicle (BDNF)
Anatomy Link Frequency
brain 16
neurons 8
nerve 6
spinal nerve 2
amygdala 2
BDNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 681 100.00 Very High Very High Very High
bDMF 278 100.00 Very High Very High Very High
depression 267 99.96 Very High Very High Very High
antidepressant 260 99.84 Very High Very High Very High
Inflammation 149 99.80 Very High Very High Very High
Spinal cord 166 99.68 Very High Very High Very High
Hippocampus 145 99.68 Very High Very High Very High
Sciatic nerve 72 99.68 Very High Very High Very High
amygdala 43 99.68 Very High Very High Very High
Inflammatory response 25 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 270 99.98 Very High Very High Very High
Depression 390 99.96 Very High Very High Very High
Injury 209 99.90 Very High Very High Very High
INFLAMMATION 168 99.80 Very High Very High Very High
Intervertebral Disk Degeneration 40 99.76 Very High Very High Very High
Hypersensitivity 50 99.52 Very High Very High Very High
Neurodegenerative Disease 128 99.48 Very High Very High Very High
Sleep Disorders 90 99.42 Very High Very High Very High
Brain Ischemia 4 99.36 Very High Very High Very High
Nociception 70 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
What are the functional effects of increased neurotrophin production during the allergic response?
Positive_regulation (increased) of Gene_expression (production) of neurotrophin associated with hypersensitivity
1) Confidence 0.67 Published 2001 Journal Respir Res Section Body Doc Link PMC59513 Disease Relevance 0.66 Pain Relevance 0.29
Based on this knowledge we hypothesised that expression of the neurotrophins NGF and BDNF increases with disc degeneration and that they are regulated by IL-1?
Positive_regulation (increases) of Gene_expression (expression) of neurotrophin associated with intervertebral disk degeneration and nerve growth factor
2) Confidence 0.67 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.23 Pain Relevance 0.38
In rodent studies, mouse pups receiving high levels of maternal care show increased neurotrophin levels in the brain, which promotes sociability in adulthood[7].
Positive_regulation (increased) of Gene_expression (levels) of neurotrophin in brain
3) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714966 Disease Relevance 0.12 Pain Relevance 0.10
Further to animal model systems, enhanced neurotrophin production has also been shown in patients with several allergic conditions.
Positive_regulation (enhanced) of Gene_expression (production) of neurotrophin associated with hypersensitivity
4) Confidence 0.67 Published 2001 Journal Respir Res Section Body Doc Link PMC59513 Disease Relevance 0.70 Pain Relevance 0.44
Together with the group of Virchow et al, we have more recently shown that neurotrophin production is increased in bronchoalveolar lavage fluids from patients undergoing segmental allergen provocation.
Positive_regulation (increased) of Gene_expression (production) of neurotrophin
5) Confidence 0.67 Published 2001 Journal Respir Res Section Body Doc Link PMC59513 Disease Relevance 0.77 Pain Relevance 0.36
An increase in BDNF protein expression was demonstrated with an increase in disease severity for all regions of the IVD (Figure 3b).
Positive_regulation (increase) of Gene_expression (expression) of BDNF protein associated with disease
6) Confidence 0.65 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.16 Pain Relevance 0.09
Increases in BDNF gene expression of twofold and 1.5-fold were demonstrated after treatment with TNF?
Positive_regulation (Increases) of Gene_expression (expression) of BDNF gene
7) Confidence 0.65 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0 Pain Relevance 0.39
on neurotrophin expression in the IVD also requires the presence of IL-1?
Positive_regulation (requires) of Gene_expression (expression) of neurotrophin
8) Confidence 0.65 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.51 Pain Relevance 0.47
Since acute stress induces variations in BDNF transcripts expression in the brain of rodents [14,17,15] we investigated if any changes occurs when fishes underwent to a brief stressful event consisting in 30 minutes of controlled water deprivation condition (see methods).
Positive_regulation (induces) of Gene_expression (expression) of BDNF in brain associated with stress
9) Confidence 0.62 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2829032 Disease Relevance 0.25 Pain Relevance 0
Our data show increased expression of BDNF with increasing severity of degeneration, which supports the recent findings of Gruber and colleagues [21].
Positive_regulation (increased) of Gene_expression (expression) of BDNF
10) Confidence 0.57 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.13 Pain Relevance 0.41
There was no similar BDNF mRNA over-expression associated with either injections of saline or rAAV-GFP.
Neg (no) Positive_regulation (over-expression) of Neg (no) Gene_expression (over-expression) of BDNF mRNA
11) Confidence 0.52 Published 2002 Journal Gene Ther. Section Abstract Doc Link 12365004 Disease Relevance 0.93 Pain Relevance 0.94
Here, we show that AAV-mediated overexpression of GDNF and BDNF in the spinal cord persisted for at least 16 weeks.
Positive_regulation (overexpression) of Gene_expression (overexpression) of BDNF in spinal cord associated with spinal cord
12) Confidence 0.49 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15380481 Disease Relevance 0.16 Pain Relevance 0.13
Therefore, tianeptine’s effectiveness as antidepressant treatment may result from its stabilization of neurotrophin levels in the amygdala.
Positive_regulation (stabilization) of Gene_expression (levels) of neurotrophin in amygdala associated with antidepressant and amygdala
13) Confidence 0.49 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701287 Disease Relevance 0.91 Pain Relevance 0.55
Most of the differential regulations, including overexpression of genes and proteins related to neurotrophin and inflammatory-immune system, occurred around 12 and 24 hours.
Positive_regulation (overexpression) of Gene_expression (overexpression) of neurotrophin in immune system associated with inflammation
14) Confidence 0.49 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2830184 Disease Relevance 0.77 Pain Relevance 0.43
BDNF is a unique neurotrophin which is synthesized by neurons and anterogradely transported [11], [12], [13] and is likely transsynaptically transfered from neurons to neurons [14].
Positive_regulation (transfered) of Gene_expression (synthesized) of neurotrophin in neurons associated with bdmf
15) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2246162 Disease Relevance 0.36 Pain Relevance 0.66
Treatment modalities particularly need to be explored, aimed to locally antagonize increased neurotrophin production.
Positive_regulation (increased) of Gene_expression (production) of neurotrophin
16) Confidence 0.45 Published 2001 Journal Respir Res Section Body Doc Link PMC59513 Disease Relevance 0.64 Pain Relevance 0.11
These neurons are known to control food intake through the production of BDNF, a neurotrophin whose expression in the VMH is increased in response to the activation of MC3/4-R [24], [32], [33].
Positive_regulation (increased) of Gene_expression (expression) of neurotrophin in MC3 associated with bdmf
17) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0.31 Pain Relevance 0.08
Extracts from ischemic rat brain have induced the production of BDNF, bFGF, VEGF and HGF in human MSCs in culture [73].
Positive_regulation (induced) of Gene_expression (production) of BDNF in HGF
18) Confidence 0.45 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0.68 Pain Relevance 0.10
RNA isolation, cDNA synthesis and reverse transcription-PCR for total BDNF expression
Positive_regulation (total) of Gene_expression (expression) of BDNF
19) Confidence 0.44 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2483719 Disease Relevance 0.13 Pain Relevance 0.44
may be an important factor with regard to upregulation of neurotrophin expression and nerve ingrowth by disc cells in the initial stages of disease.
Positive_regulation (upregulation) of Gene_expression (expression) of neurotrophin in nerve associated with disease
20) Confidence 0.44 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.48 Pain Relevance 0.45

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