INT103474

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Context Info
Confidence 0.60
First Reported 2001
Last Reported 2010
Negated 6
Speculated 4
Reported most in Body
Documents 40
Total Number 44
Disease Relevance 12.14
Pain Relevance 9.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (BDNF) cytoplasmic membrane-bounded vesicle (BDNF)
Anatomy Link Frequency
SH-SY5Y 8
brain 8
hippocampus 4
nerve 4
cortex 4
BDNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 545 100.00 Very High Very High Very High
antidepressant 442 100.00 Very High Very High Very High
cytokine 140 100.00 Very High Very High Very High
Hippocampus 88 100.00 Very High Very High Very High
Neuropeptide 87 100.00 Very High Very High Very High
bDMF 21 100.00 Very High Very High Very High
fluoxetine 132 99.72 Very High Very High Very High
depression 84 99.62 Very High Very High Very High
Inflammation 20 99.56 Very High Very High Very High
cerebral cortex 22 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 322 100.00 Very High Very High Very High
Disease 265 99.68 Very High Very High Very High
Injury 17 99.66 Very High Very High Very High
Depression 176 99.62 Very High Very High Very High
Neuroblastoma 78 99.60 Very High Very High Very High
INFLAMMATION 22 99.56 Very High Very High Very High
Hypersensitivity 14 99.52 Very High Very High Very High
Low Back Pain 42 99.00 Very High Very High Very High
Diabetes Mellitus 94 98.48 Very High Very High Very High
Anxiety Disorder 15 98.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some agents modulate the expression of the neurotrophins themselves, while others act by enhancing neurotrophin action.
Regulation (modulate) of Gene_expression (expression) of neurotrophin
1) Confidence 0.60 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.39 Pain Relevance 0.13
When observing the effects on BDNF gene expression, treatment with the proinflammatory cytokine IL-1?
Regulation (effects) of Gene_expression (expression) of BDNF gene associated with cytokine
2) Confidence 0.58 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0 Pain Relevance 0.38
Additionally these cytokines have been shown to regulate neurotrophin expression in non-neuronal cells.
Regulation (regulate) of Gene_expression (expression) of neurotrophin in neuronal associated with cytokine
3) Confidence 0.58 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.41 Pain Relevance 0.47
This indicates that antiBDNF transcripts could have an important role in the regulation of BDNF expression in human.
Regulation (regulation) of Gene_expression (expression) of BDNF
4) Confidence 0.55 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0.03
An alternative explanation could be found in the lack of changes in BDNF expression after fluoxetine treatment in rodents, as reported by several studies [9,27-30].
Regulation (changes) of Gene_expression (expression) of BDNF associated with fluoxetine
5) Confidence 0.54 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2483719 Disease Relevance 0 Pain Relevance 0.48
Since alterations in BDNF expression were also found in response to emotions such as anxiety or fear in rodents [22] and BDNF affects emotional preferences in humans [23], it remains to be determined how the stress itself or the associated behavioral responses contribute in mediating these changes.
Regulation (alterations) of Gene_expression (expression) of BDNF associated with stress and anxiety disorder
6) Confidence 0.48 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2829032 Disease Relevance 1.16 Pain Relevance 0.13
Effects of acute stress on the expression of BDNF splice variants
Regulation (Effects) of Gene_expression (expression) of BDNF associated with stress
7) Confidence 0.48 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2829032 Disease Relevance 0.20 Pain Relevance 0
In particular, it has been shown that chronic defeat stress, a model of depression, selectively down-regulated in mouse hippocampus the expression of BDNF III and BDNF IV transcripts (corresponding in the present study to BDNF IV and BDNF VIa/b respectively, according to the new nomenclature of BDNF gene), while chronic imipramine treatment reversed this down-regulation [12].
Regulation (regulated) of Gene_expression (expression) of BDNF III in hippocampus associated with stress, depression and hippocampus
8) Confidence 0.45 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2483719 Disease Relevance 0.20 Pain Relevance 0.38
In particular, it has been shown that chronic defeat stress, a model of depression, selectively down-regulated in mouse hippocampus the expression of BDNF III and BDNF IV transcripts (corresponding in the present study to BDNF IV and BDNF VIa/b respectively, according to the new nomenclature of BDNF gene), while chronic imipramine treatment reversed this down-regulation [12].
Regulation (regulated) of Gene_expression (expression) of BDNF IV in hippocampus associated with stress, depression and hippocampus
9) Confidence 0.45 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2483719 Disease Relevance 0.20 Pain Relevance 0.38
Therefore, aim of the present study was to investigate whether antidepressant treatments of different time lengths induce changes in the expression of BDNF gene also in cultured human cells and to assess whether these modifications could be explained by differential regulation of BDNF transcripts.
Spec (investigate) Regulation (changes) of Gene_expression (expression) of BDNF gene associated with antidepressant
10) Confidence 0.45 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2483719 Disease Relevance 0.22 Pain Relevance 0.16
RESULTS: The CSF concentrations of CNTF, BDNF, and NGF did not differ between the 3 patient cohorts.
Neg (not) Regulation (differ) of Gene_expression (concentrations) of BDNF in CSF
11) Confidence 0.44 Published 2009 Journal Clin J Pain Section Body Doc Link 19920725 Disease Relevance 0.26 Pain Relevance 0
What are the functional effects of increased neurotrophin production during the allergic response?
Regulation (effects) of Gene_expression (production) of neurotrophin associated with hypersensitivity
12) Confidence 0.44 Published 2001 Journal Respir Res Section Body Doc Link PMC59513 Disease Relevance 0.72 Pain Relevance 0.29
Using immunohistochemistry we have therefore investigated NGF and BDNF expression, including expression of the receptors Trk-A and Trk-B, in non-degenerate, moderately degenerate and severely degenerate human IVD tissue, and we have examined the effects of IL-1?
Spec (investigated) Regulation (investigated) of Spec (investigated) Gene_expression (expression) of BDNF associated with nerve growth factor
13) Confidence 0.42 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.16 Pain Relevance 0.34
Effect of proinflammatory cytokines on neurotrophin and neuropeptide gene expression in nondegenerate and degenerate nucleus pulposus cells
Regulation (Effect) of Gene_expression (expression) of neurotrophin in nucleus pulposus associated with neuropeptide and cytokine
14) Confidence 0.42 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0 Pain Relevance 0.10
in the modulation of neurotrophin expression in the IVD comes from studies by Abe and colleagues, who demonstrated an increase in NGF gene expression and protein secretion after NP cells (cultured in monolayer) were treated with IL-1?
Regulation (modulation) of Gene_expression (expression) of neurotrophin associated with nerve growth factor
15) Confidence 0.42 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.36 Pain Relevance 0.43
in the modulation of neurotrophin and neuropeptide expression in cells from the IVD seeded in a three-dimensional matrix.
Regulation (modulation) of Gene_expression (expression) of neurotrophin associated with neuropeptide
16) Confidence 0.42 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.14 Pain Relevance 0.37
In order to verify our conclusion regarding the expression level of BDNF in the AD patients in our dataset, we examined the expression level of BDNF in the controls and AD affected samples.
Spec (examined) Regulation (verify) of Gene_expression (expression) of BDNF associated with disease and bdmf
17) Confidence 0.39 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.74 Pain Relevance 0.47
DISCUSSION: We did not detect any difference between patients with neuropathic versus nociceptive pain and nonpainful controls for spinal CNTF, BDNF, and NGF levels.
Neg (not) Regulation (controls) of Gene_expression (levels) of BDNF in spinal
18) Confidence 0.38 Published 2009 Journal Clin J Pain Section Body Doc Link 19920725 Disease Relevance 0.22 Pain Relevance 0
For changes in gene expression or brain-derived neurotrophic factor (BDNF) levels, however, the most reliable data are for pre- to post-treatment changes, and the question of how early in treatment changes that might be predictive of outcome could be detected remains unclear.
Regulation (changes) of Gene_expression (expression) of BDNF in brain
19) Confidence 0.35 Published 2010 Journal Curr Psychiatry Rep Section Body Doc Link PMC2965366 Disease Relevance 0.21 Pain Relevance 0.07
For changes in gene expression or brain-derived neurotrophic factor (BDNF) levels, however, the most reliable data are for pre- to post-treatment changes, and the question of how early in treatment changes that might be predictive of outcome could be detected remains unclear.
Regulation (changes) of Gene_expression (expression) of brain-derived neurotrophic factor in brain
20) Confidence 0.35 Published 2010 Journal Curr Psychiatry Rep Section Body Doc Link PMC2965366 Disease Relevance 0.21 Pain Relevance 0.07

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