INT103477

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Context Info
Confidence 0.52
First Reported 2002
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 23
Total Number 24
Disease Relevance 10.63
Pain Relevance 6.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (BDNF) cytoplasmic membrane-bounded vesicle (BDNF)
Anatomy Link Frequency
brain 10
caudate nucleus 3
plasma 2
prefrontal 2
precursor cells 2
BDNF (Homo sapiens)
Pain Link Frequency Relevance Heat
bDMF 70 100.00 Very High Very High Very High
ischemia 11 100.00 Very High Very High Very High
antidepressant 163 99.78 Very High Very High Very High
fluoxetine 55 99.78 Very High Very High Very High
tetrodotoxin 4 99.76 Very High Very High Very High
depression 220 99.60 Very High Very High Very High
neurotrophin 3 8 99.20 Very High Very High Very High
Desipramine 46 99.18 Very High Very High Very High
Substantia nigra 3 97.64 Very High Very High Very High
Thalamus 4 97.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stroke 34 100.00 Very High Very High Very High
Cv Unclassified Under Development 8 100.00 Very High Very High Very High
Stress 193 99.98 Very High Very High Very High
Disease 429 99.84 Very High Very High Very High
Infection 53 99.62 Very High Very High Very High
Depression 300 99.60 Very High Very High Very High
Suicidal Behaviour 130 99.56 Very High Very High Very High
Anxiety Disorder 39 99.54 Very High Very High Very High
Cardiovascular Disease 102 99.48 Very High Very High Very High
Injury 37 97.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BDNF expression was also very low in the globus pallidus, striatum (caudate nucleus and putamen), and thalamus, with the exception of exon IXabcd transcripts, which were expressed at relatively high levels in these regions.
Negative_regulation (low) of Gene_expression (expression) of BDNF in caudate nucleus associated with thalamus
1) Confidence 0.52 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0.08 Pain Relevance 0.23
In particular, RBX and DMI exerted a biphasic effect on BDNF mRNA: BDNF mRNA expression was reduced after 6 hours treatment with RBX or DMI, returned to basal level at 24 hours and was significantly increased after 48 hours (Fig. 2A).
Negative_regulation (reduced) of Gene_expression (expression) of BDNF mRNA associated with desipramine
2) Confidence 0.43 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2483719 Disease Relevance 0.08 Pain Relevance 0.44
It has been shown that BDNF expression and/or function is impaired in major depression or following stress paradigms, while it is up-regulated by physical exercise and antidepressants.
Negative_regulation (impaired) of Gene_expression (expression) of BDNF associated with stress, antidepressant and depression
3) Confidence 0.43 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2483719 Disease Relevance 0.30 Pain Relevance 0.22
Subsequently, we applied the EAR normalization tool for the quantification of BDNF mRNA in the eight control participants analyzed in Figure 1, in which the messenger level of the neurotrophin is represented relative to GAPDH or ?
Negative_regulation (applied) of Gene_expression (quantification) of BDNF mRNA
4) Confidence 0.42 Published 2010 Journal Genome Biol Section Body Doc Link PMC2847721 Disease Relevance 0 Pain Relevance 0
Given the remarkable reduction in brain BDNF mRNA levels in HD, we set up a fast, accurate, and standardized method for BDNF mRNA detection in blood.
Negative_regulation (reduction) of Gene_expression (levels) of BDNF mRNA in blood associated with disease
5) Confidence 0.42 Published 2010 Journal Genome Biol Section Body Doc Link PMC2847721 Disease Relevance 0.67 Pain Relevance 0.03
Reduced expression of neurotrophins181,210 together with reduced expression and activation of Trk and concomitant increased expression of p75NTR indicate that the possible consequence is a tipping of the balance away from cell survival, which could be associated with structural abnormalities and reduced neuronal plasticity in suicide brain specimens.
Negative_regulation (Reduced) of Gene_expression (expression) of neurotrophin in brain associated with suicidal behaviour and congenital anomalies
6) Confidence 0.42 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.71 Pain Relevance 0.06
Further validation of proliferation arrest in neuronal precursor cells and reduced DCX expression with progressive infection was obtained from decreased expression of neurotrophins, such as BDNF and NT3.
Negative_regulation (decreased) of Gene_expression (expression) of neurotrophin in precursor cells associated with neurotrophin 3 and infection
7) Confidence 0.41 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.99 Pain Relevance 0.17
In Ts65Dn mice, fluoxetine treatment restored the expression of 5-HT1A receptors and BDNF.
Negative_regulation (restored) of Gene_expression (expression) of BDNF associated with fluoxetine
8) Confidence 0.41 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20592198 Disease Relevance 0.89 Pain Relevance 0.43
Expression of alternatively spliced BDNF and antiBDNF mRNAs in adult human brain regions
Negative_regulation (spliced) of Gene_expression (mRNAs) of BDNF in brain
9) Confidence 0.38 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0.07 Pain Relevance 0.10
Indeed, independent investigations showed that short-term antidepressant treatment decreased BDNF expression in rodents, whereas long-term treatment increased BDNF [4-6].
Negative_regulation (decreased) of Gene_expression (expression) of BDNF associated with antidepressant
10) Confidence 0.38 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2483719 Disease Relevance 0.32 Pain Relevance 0.25
CONCLUSION: The BDNF(Met/Met) genotype has a protective effect on the occurrence of UAP, which might in part be due to the decreased plasma hsCRP level in BDNF(Met/Met) carriers.
Negative_regulation (decreased) of Gene_expression (level) of BDNF in plasma
11) Confidence 0.37 Published 2009 Journal Clin. Chim. Acta Section Body Doc Link 19013140 Disease Relevance 0.06 Pain Relevance 0
By this reasoning, it can be concluded that high levels of TrkB and PAI-1 imply decreased levels of BDNF, which is detrimental for the survival of neuronal populations.
Negative_regulation (decreased) of Gene_expression (levels) of BDNF in neuronal associated with bdmf
12) Confidence 0.37 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.74 Pain Relevance 0.54
Decreased levels of BDNF have been linked to AD and depression [38-40].
Negative_regulation (Decreased) of Gene_expression (levels) of BDNF associated with depression, disease and bdmf
13) Confidence 0.37 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.61 Pain Relevance 0.53
Decreased levels of brain-derived neurotrophic factor
Negative_regulation (Decreased) of Gene_expression (levels) of brain-derived neurotrophic factor in brain
14) Confidence 0.36 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.76 Pain Relevance 0.47
To investigate the persistence of BDNF expression in vivo, brain tissues (2 mm segment centered on the injection site) were harvested and lysed in a RIPA buffer at 1, 3, 7, 10, and 14 days after treatment of cells.
Spec (investigate) Negative_regulation (persistence) of Spec (investigate) Gene_expression (expression) of BDNF in brain
15) Confidence 0.36 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2883955 Disease Relevance 0 Pain Relevance 0.04
Indeed, several types of injury and cell stress affect the expression of BDNF in the mammalian brain; in particular, chronic stress decreases the synthesis of hippocampal BDNF [10-13] while acute stress induces complex alterations in the expression of BDNF, including a decrease in the hippocampus and an increase in the prefrontal cortex [14-17].
Negative_regulation (decreases) of Gene_expression (synthesis) of BDNF in cortex associated with stress, injury and hippocampus
16) Confidence 0.34 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2829032 Disease Relevance 0.83 Pain Relevance 0.10
In control groups, expression levels of BDNF were low throughout the experimental period (Figure 7B, left panel).
Negative_regulation (levels) of Gene_expression (expression) of BDNF
17) Confidence 0.31 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2883955 Disease Relevance 0.16 Pain Relevance 0.03
A recent study has also reported that transplanted porcine choroids plexus in microcapsules improved behavioral performance and decreased the pathological lesion size in rat ischemia stroke model by producing several trophic factors including NGF, BDNF and GDNF [82].
Negative_regulation (decreased) of Gene_expression (producing) of BDNF in choroids associated with stroke and ischemia
18) Confidence 0.24 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0.63 Pain Relevance 0.13
Antidepressant medications and voluntary exercise can enhance BDNF, while diets high in saturated fat and sucrose, and psychological stress inhibit BDNF production [36].


Negative_regulation (inhibit) of Gene_expression (production) of BDNF in fat associated with stress, antidepressant and bdmf
19) Confidence 0.20 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC533861 Disease Relevance 0.75 Pain Relevance 0.82
BDNF expression was also very low in the globus pallidus, striatum (caudate nucleus and putamen), and thalamus, with the exception of exon IXabcd transcripts, which were expressed at relatively high levels in these regions.
Negative_regulation (low) of in putamen Gene_expression (expression) of BDNF in caudate nucleus associated with thalamus
20) Confidence 0.18 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0.08 Pain Relevance 0.23

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