INT103487

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Context Info
Confidence 0.67
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 4.08
Pain Relevance 2.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lep) extracellular region (Lep) intracellular (Lep)
lipid metabolic process (Lep)
Anatomy Link Frequency
placenta 4
liver 3
fat 2
astrocytes 2
skeletal muscle 1
Lep (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 38 100.00 Very High Very High Very High
cytokine 25 100.00 Very High Very High Very High
Calcitonin gene-related peptide 20 100.00 Very High Very High Very High
substance P 18 100.00 Very High Very High Very High
chemokine 2 100.00 Very High Very High Very High
Pain 1 100.00 Very High Very High Very High
Opioid 7 96.64 Very High Very High Very High
Neuropeptide 7 95.36 Very High Very High Very High
Kappa opioid receptor 1 94.16 High High
agonist 25 92.40 High High
Disease Link Frequency Relevance Heat
Obesity 57 100.00 Very High Very High Very High
INFLAMMATION 38 100.00 Very High Very High Very High
Overweight 6 100.00 Very High Very High Very High
Pain 1 100.00 Very High Very High Very High
Insulin Resistance 30 99.28 Very High Very High Very High
Heart Rate Under Development 1 97.52 Very High Very High Very High
Diabetes Mellitus 31 93.80 High High
Birth Weight 1 89.28 High High
Neurogenic Inflammation 1 87.52 High High
Body Weight 7 85.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, naltrexone induced an increase in serum leptin compared with pair-fed controls.
Positive_regulation (induced) of Positive_regulation (increase) of leptin
1) Confidence 0.67 Published 2002 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 12069941 Disease Relevance 0.09 Pain Relevance 0.51
Circulating leptin correlated well with fat mass and increased more after vasoconstrictor infusion in NR sheep.
Positive_regulation (increased) of Positive_regulation (Circulating) of leptin in fat
2) Confidence 0.48 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 14975924 Disease Relevance 0.26 Pain Relevance 0.12
The elevated levels of plasma leptin as wells as the increased mRNAs expression of the leptin receptors in placenta indicate the significant role of the hormone in fetal growth and development.
Positive_regulation (elevated) of Positive_regulation (levels) of plasma leptin in placenta
3) Confidence 0.38 Published 2006 Journal Reprod Biol Section Abstract Doc Link 16967091 Disease Relevance 0 Pain Relevance 0.06
The elevated levels of plasma leptin as wells as the increased mRNAs expression of the leptin receptors in placenta indicate the significant role of the hormone in fetal growth and development.
Positive_regulation (levels) of Positive_regulation (elevated) of plasma leptin in placenta
4) Confidence 0.38 Published 2006 Journal Reprod Biol Section Abstract Doc Link 16967091 Disease Relevance 0 Pain Relevance 0.06
Next, we investigated whether the increased sensitivity of the leptin action on food intake induced by exercise, could be due to the modulation of AMPK activity.
Positive_regulation (increased) of Positive_regulation (induced) of leptin
5) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.29 Pain Relevance 0
Furthermore, stimulation of the co-cultured astrocytes with 5-HT generated a pronounced increase in intracellular Ca(2+) release in the presence of the inflammatory or pain mediating activators substance P, calcitonin gene-related peptide (CGRP), lipopolysaccharide (LPS), or leptin.
Positive_regulation (generated) of Positive_regulation (calcitonin) of leptin in astrocytes associated with pain, inflammation, calcitonin gene-related peptide and substance p
6) Confidence 0.33 Published 2008 Journal Neuroscience Section Abstract Doc Link 18692967 Disease Relevance 0.28 Pain Relevance 1.25
These effects are mediated in part by induction of downstream inflammatory cytokines and chemokines, especially IL-1beta, IL-18, and leptin.
Positive_regulation (mediated) of Positive_regulation (induction) of leptin associated with chemokine, inflammation and cytokine
7) Confidence 0.17 Published 2010 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 20543002 Disease Relevance 0.73 Pain Relevance 0.38
A sufficient leptin signal is also essential for normal activity at all levels of the HPG axis (439).
Positive_regulation (essential) of Positive_regulation (sufficient) of leptin
8) Confidence 0.11 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.09 Pain Relevance 0
When pure F was used instead of HFCS, no postprandial HTG was observed for oral intakes up to approximately 50 g/d.17 HTG and fasting ApoB was, however, increased in overweight or obese women.18 Fasting increased levels of TG, VLDL-TAG and leptin without inducing insulin resistance or ectopic fat deposition in healthy males after four weeks of HF administration.19 More recently, however, the same group reported that just one week of HF administration increased ectopic fat deposition in the liver and skeletal muscle, with a greater effect seen in the offspring of diabetic parents than in healthy controls.20
Positive_regulation (increased) of Positive_regulation (increased) of leptin in liver associated with diabetes mellitus, obesity, insulin resistance and overweight
9) Confidence 0.11 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2910863 Disease Relevance 1.12 Pain Relevance 0
When pure F was used instead of HFCS, no postprandial HTG was observed for oral intakes up to approximately 50 g/d.17 HTG and fasting ApoB was, however, increased in overweight or obese women.18 Fasting increased levels of TG, VLDL-TAG and leptin without inducing insulin resistance or ectopic fat deposition in healthy males after four weeks of HF administration.19 More recently, however, the same group reported that just one week of HF administration increased ectopic fat deposition in the liver and skeletal muscle, with a greater effect seen in the offspring of diabetic parents than in healthy controls.20
Positive_regulation (increased) of in skeletal muscle Positive_regulation (increased) of leptin in liver associated with diabetes mellitus, obesity, insulin resistance and overweight
10) Confidence 0.04 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2910863 Disease Relevance 1.12 Pain Relevance 0

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