INT103488

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Context Info
Confidence 0.50
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.05
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (App) Golgi apparatus (App) plasma membrane (App)
extracellular matrix organization (App) DNA binding (App) cytoplasm (App)
Anatomy Link Frequency
SH-SY5Y 2
neurons 2
cleavage 2
astrocytes 2
App (Rattus norvegicus)
Pain Link Frequency Relevance Heat
sSRI 96 96.68 Very High Very High Very High
cINOD 9 96.58 Very High Very High Very High
Abeta 3 93.84 High High
Inflammation 3 83.92 Quite High
depression 25 80.68 Quite High
Kinase C 1 73.20 Quite High
Neurotransmitter 2 70.20 Quite High
agonist 3 60.52 Quite High
5HT 18 20.32 Low Low
fluoxetine 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 16 100.00 Very High Very High Very High
Syndrome 122 99.76 Very High Very High Very High
Parkinson's Disease 6 99.24 Very High Very High Very High
Neuroblastoma 1 96.08 Very High Very High Very High
Disease 139 94.80 High High
Toxicity 2 94.20 High High
INFLAMMATION 5 90.16 High High
Drug Induced Neurotoxicity 2 82.60 Quite High
Depression 30 80.68 Quite High
Congenital Anomalies 4 75.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This indicates that they capture some aspects that are important for the reporting of APP.
Positive_regulation (important) of Localization (reporting) of APP
1) Confidence 0.50 Published 2008 Journal Environ Health Section Body Doc Link PMC2289819 Disease Relevance 0.08 Pain Relevance 0.04
In addition, IBU-PO enhances, dose-dependently, the non-amyloidogenic amyloid precursor protein (APP) cleavage by increasing secreted APP and decreasing endogenous Abeta1-40 in rat hippocampal neurons.
Positive_regulation (increasing) of Localization (secreted) of APP in cleavage associated with alzheimer's dementia
2) Confidence 0.34 Published 2005 Journal Neurobiol. Dis. Section Abstract Doc Link 15649708 Disease Relevance 0.65 Pain Relevance 0.31
Pakaski et al (2005) report an increase in APP secretion resulting from in vitro treatment of rat basal forebrain neurons with a different SSRI, citalopram, but the benefit of this result seems counterintuitive.
Positive_regulation (increase) of Localization (secretion) of APP in neurons associated with ssri
3) Confidence 0.25 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656299 Disease Relevance 0.40 Pain Relevance 0.30
Our previous research indicates the presence of mitochondrial dysfunction and energy deficits in DS astrocytes leading to abnormal amyloid precursor protein (APP) processing and secretion, and to intracellular accumulation of amyloid ?
Positive_regulation (leading) of Localization (secretion) of amyloid precursor protein in astrocytes associated with parkinson's disease, syndrome and alzheimer's dementia
4) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 1.21 Pain Relevance 0
Here we report that various NSAIDs, such as the cyclooxygenase inhibitors, nimesulide, ibuprofen and indomethacin, as well as thalidomide (Thal) and its non-teratogenic analogue, supidimide, significantly stimulated the secretion of the non-amyloidogenic alpha-secretase form of the soluble amyloid precursor protein (sAPP alpha) into the conditioned media of SH-SY5Y neuroblastoma and PC12 cells.
Positive_regulation (stimulated) of Localization (secretion) of non-amyloidogenic alpha-secretase in SH-SY5Y associated with neuroblastoma, alzheimer's dementia and cinod
5) Confidence 0.01 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12070143 Disease Relevance 0.71 Pain Relevance 0.63

General Comments

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