INT10349

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Context Info
Confidence 0.58
First Reported 1987
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 48
Total Number 49
Disease Relevance 25.53
Pain Relevance 24.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b) aging (Il1b) extracellular region (Il1b)
Anatomy Link Frequency
neurons 5
brain 4
blood 3
PGE 2
nerves 2
Il1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 89 100.00 Very High Very High Very High
cytokine 49 100.00 Very High Very High Very High
Analgesic 30 99.98 Very High Very High Very High
narcan 27 99.98 Very High Very High Very High
Intracerebroventricular 15 99.98 Very High Very High Very High
Hyperalgesia 44 99.88 Very High Very High Very High
dexamethasone 3 99.76 Very High Very High Very High
Spinal cord 4 99.50 Very High Very High Very High
qutenza 26 99.44 Very High Very High Very High
trigeminal ganglion 16 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 92 100.00 Very High Very High Very High
Ulcers 14 100.00 Very High Very High Very High
Necrosis 12 100.00 Very High Very High Very High
Cancer 12 100.00 Very High Very High Very High
Hypoglycemia 4 100.00 Very High Very High Very High
Hyperalgesia 62 99.98 Very High Very High Very High
Fever 21 99.96 Very High Very High Very High
Increased Venous Pressure Under Development 11 99.90 Very High Very High Very High
Pancreatitis 6 99.74 Very High Very High Very High
Ganglion Cysts 20 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indomethacin (10 mg/kg, i.p.) did not alter the capsaicin-induced vasodilatation but prevented IL-1 beta (50 pg) from augmenting the hyperemic response to capsaicin.
Negative_regulation (prevented) of IL-1 beta associated with qutenza and increased venous pressure under development
1) Confidence 0.58 Published 1995 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 8846404 Disease Relevance 0.88 Pain Relevance 0.77
RESULTS: Histamine alone reduced ulcer area evoked by stress and this effect was accompanied by an increase in gastric mucosal blood flow and mucosal DNA synthesis, as well as a decrease in serum pro-inflammatory interleukin-1beta concentration.
Negative_regulation (decrease) of interleukin-1beta in blood associated with stress, inflammation and ulcers
2) Confidence 0.57 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15680274 Disease Relevance 1.15 Pain Relevance 0.44
The plasma levels of cytokines (IL-1beta, IL-6, TNF-alpha, and IFN-gamma) and hypoglycemia induced by LPS were also reduced by urgosedin.
Negative_regulation (reduced) of IL-1beta in plasma associated with hypoglycemia and cytokine
3) Confidence 0.57 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15475835 Disease Relevance 0.74 Pain Relevance 0.23
Pharmacological blockade of tumour necrosis factor-alpha (TNFalpha) or interleukin-1beta (IL-1beta) reduced the hyperalgesic response to venom.
Negative_regulation (blockade) of interleukin-1beta associated with hyperalgesia, necrosis and cancer
4) Confidence 0.57 Published 2004 Journal Brain Res. Section Abstract Doc Link 15328037 Disease Relevance 0.90 Pain Relevance 1.35
Serum IL-1beta and IL-6 levels were significantly higher at 2, 4, and 8 hours after LPS injection and were equally suppressed in the laparotomy and laparoscopic groups (P < 0.05).
Negative_regulation (suppressed) of IL-1beta
5) Confidence 0.57 Published 2005 Journal Surg Laparosc Endosc Percutan Tech Section Abstract Doc Link 15956894 Disease Relevance 0.47 Pain Relevance 0.22
Liver IL-1beta mRNA and protein levels were significantly inhibited at 2, 4, and 8 hours in the laparotomy and laparoscopic groups.
Negative_regulation (inhibited) of IL-1beta in Liver
6) Confidence 0.57 Published 2005 Journal Surg Laparosc Endosc Percutan Tech Section Abstract Doc Link 15956894 Disease Relevance 0.44 Pain Relevance 0.23
Pharmacological blockade of tumour necrosis factor-alpha (TNFalpha) or interleukin-1beta (IL-1beta) reduced the hyperalgesic response to venom.
Negative_regulation (blockade) of IL-1beta associated with hyperalgesia, necrosis and cancer
7) Confidence 0.57 Published 2004 Journal Brain Res. Section Abstract Doc Link 15328037 Disease Relevance 0.90 Pain Relevance 1.35
Ranitidine, in combination with histamine, reduced the ulcer area and serum interleukin-1beta to a minimal value, whereas gastric mucosal blood flow and DNA synthesis reached a maximal value.
Negative_regulation (reduced) of interleukin-1beta in blood associated with ulcers
8) Confidence 0.57 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15680274 Disease Relevance 1.11 Pain Relevance 0.32
These results indicate that the protective effect by ghrelin in the spinal cord is mediated through the suppression of TNF-alpha and IL-1beta.
Negative_regulation (suppression) of IL-1beta in spinal cord associated with spinal cord
9) Confidence 0.57 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20561937 Disease Relevance 0.75 Pain Relevance 0.95
On a molar basis, Il-1 beta was the most potent inhibitor of LH secretion.
Negative_regulation (inhibitor) of Il-1 beta in molar
10) Confidence 0.55 Published 1990 Journal Endocrinology Section Abstract Doc Link 2115435 Disease Relevance 0.19 Pain Relevance 0.21
It also significantly suppressed local tissue TNF-alpha and IL-1beta (p<0.05).
Negative_regulation (suppressed) of IL-1beta
11) Confidence 0.52 Published 2005 Journal J Ethnopharmacol Section Abstract Doc Link 15970410 Disease Relevance 1.14 Pain Relevance 0.42
An i.v. injection of cyclooxygenase inhibitors (6 mg ibuprofen or 20 mg sodium salicylate) suppressed almost completely the rhIL-1 beta (100 pg)-induced activity in adrenal and splenic nerves.
Negative_regulation (suppressed) of rhIL-1 beta in nerves
12) Confidence 0.43 Published 1991 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 1787257 Disease Relevance 0 Pain Relevance 0
IL-1 beta (0.1 pg-200 ng) decreased the threshold value to 58% of the control pressure required for firing.
Negative_regulation (decreased) of IL-1 beta
13) Confidence 0.43 Published 1994 Journal Brain Res. Section Abstract Doc Link 7820610 Disease Relevance 0.21 Pain Relevance 0.33
Pretreatment with a neurotoxic dose of capsaicin reduced the capsaicin-evoked hyperaemia and prevented the facilitatory effect of interleukin-1 beta.
Negative_regulation (effect) of interleukin-1 beta associated with qutenza and increased venous pressure under development
14) Confidence 0.43 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7957631 Disease Relevance 0.27 Pain Relevance 0.46
We determined the effect on feeding of Lys-D-Pro-Thr (LDPT), an interleukin-1 beta 193-195 analogue which antagonizes the analgesic effects of interleukin-1 beta.
Negative_regulation (effects) of interleukin-1 beta associated with analgesic
15) Confidence 0.43 Published 1991 Journal Neuropeptides Section Abstract Doc Link 1891074 Disease Relevance 0 Pain Relevance 0.15
An i.c.v. injection of sodium salicylate 15 min prior to interleukin-1 beta administration inhibited the hyperalgesic effect of interleukin-1 beta, but not the analgesic effect.
Negative_regulation (administration) of interleukin-1 beta associated with hyperalgesia and analgesic
16) Confidence 0.42 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8741165 Disease Relevance 0.60 Pain Relevance 0.56
An i.c.v. injection of alpha-helical-corticotropin-releasing factor [9-41] 15 min prior to interleukin-1 beta administration completely blocked the hyperalgesic and analgesic effects of interleukin-1 beta.
Negative_regulation (effects) of interleukin-1 beta associated with hyperalgesia and analgesic
17) Confidence 0.42 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8741165 Disease Relevance 0.59 Pain Relevance 0.57
An i.c.v. injection of sodium salicylate 15 min prior to interleukin-1 beta administration inhibited the hyperalgesic effect of interleukin-1 beta, but not the analgesic effect.
Negative_regulation (effect) of interleukin-1 beta associated with hyperalgesia and analgesic
18) Confidence 0.42 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8741165 Disease Relevance 0.59 Pain Relevance 0.55
Expression of the c-fos proto-oncogene in the rat brain was examined by immunostaining for fos, the nuclear protein product of the c-fos gene, after injection of interleukin-1-beta (IL-1 beta) into the gingiva of an incisor.
Negative_regulation (injection) of interleukin-1-beta in brain
19) Confidence 0.42 Published 1994 Journal Brain Res. Bull. Section Abstract Doc Link 8193934 Disease Relevance 0.19 Pain Relevance 0.14
Expression of the c-fos proto-oncogene in the rat brain was examined by immunostaining for fos, the nuclear protein product of the c-fos gene, after injection of interleukin-1-beta (IL-1 beta) into the gingiva of an incisor.
Negative_regulation (injection) of IL-1 beta in brain
20) Confidence 0.42 Published 1994 Journal Brain Res. Bull. Section Abstract Doc Link 8193934 Disease Relevance 0.19 Pain Relevance 0.14

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