INT10350

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Context Info
Confidence 0.41
First Reported 1992
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.58
Pain Relevance 2.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b) aging (Il1b) extracellular region (Il1b)
Il1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 9 100.00 Very High Very High Very High
tolerance 9 100.00 Very High Very High Very High
antagonist 9 98.00 Very High Very High Very High
Calcitonin gene-related peptide 7 97.56 Very High Very High Very High
Antinociceptive 1 91.32 High High
Spinal cord 1 88.44 High High
Hyperalgesia 2 87.68 High High
Inflammation 2 83.00 Quite High
cINOD 6 81.04 Quite High
cytokine 1 80.44 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 2 87.68 High High
INFLAMMATION 4 83.00 Quite High
Injury 1 82.32 Quite High
Fever 1 79.44 Quite High
Pain 1 67.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, the inhibition of the ERK pathway suppressed the development of tolerance and morphine-induced up-regulation of IL-1beta, TNF-alpha, and mPGES-1.
Negative_regulation (suppressed) of Regulation (regulation) of IL-1beta associated with tolerance and morphine
1) Confidence 0.41 Published 2009 Journal FASEB J. Section Abstract Doc Link 19299480 Disease Relevance 0.07 Pain Relevance 1.80
The effect of 1.25 micrograms IL-1 beta/rat on food intake measured 4 and 22 h after (IP) injection was blocked by coadministration of 5 mg tripeptide IL-1 beta antagonist.
Negative_regulation (blocked) of Regulation (effect) of IL-1 beta associated with antagonist
2) Confidence 0.39 Published 1992 Journal Physiol. Behav. Section Abstract Doc Link 1484875 Disease Relevance 0.33 Pain Relevance 0.44
Moreover, the addition of PGE2 to indomethacin-treated cells all but reversed the ability of indomethacin to suppress the IL-1beta effect at both the PGS-2 transcript and protein levels.
Negative_regulation (suppress) of Regulation (effect) of IL-1beta
3) Confidence 0.04 Published 1999 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 10619394 Disease Relevance 0.18 Pain Relevance 0.46

General Comments

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