INT103518

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Context Info
Confidence 0.57
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 8.40
Pain Relevance 5.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (SCN2A)
Anatomy Link Frequency
plasma 3
SCN2A (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 17 100.00 Very High Very High Very High
tetrodotoxin 11 100.00 Very High Very High Very High
lidocaine 1 99.36 Very High Very High Very High
Angina 5 99.26 Very High Very High Very High
antagonist 4 98.66 Very High Very High Very High
Cannabinoid 2 98.14 Very High Very High Very High
Root ganglion neuron 4 96.68 Very High Very High Very High
Potency 1 93.60 High High
Bioavailability 4 92.48 High High
nud 2 91.68 High High
Disease Link Frequency Relevance Heat
Thalassemia 187 99.72 Very High Very High Very High
Diabetes Mellitus 42 99.68 Very High Very High Very High
Cv General 3 Under Development 7 99.26 Very High Very High Very High
Epilepsy 1 98.52 Very High Very High Very High
Disorder Of Lipid Metabolism 7 98.40 Very High Very High Very High
Hypopituitarism 1 97.12 Very High Very High Very High
Ganglion Cysts 4 96.36 Very High Very High Very High
Heart Arrhythmia 1 95.16 Very High Very High Very High
Hypoglycemia 11 93.32 High High
Dyspepsia 2 91.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The drug appeared most efficacious in patients who had previously been treated by diet alone, where significant reductions in HbA(1c) from baseline of 0.9% and 0.95% were seen at 10 and 24 months.
Negative_regulation (reductions) of HbA
1) Confidence 0.57 Published 2002 Journal Drugs Section Abstract Doc Link 12076188 Disease Relevance 0.58 Pain Relevance 0.16
Similarly, a sustained effect of gliclazide MR was observed in a subgroup of elderly patients defined a priori; HbA(1c) was decreased to a similar degree to that observed in the general study population.
Negative_regulation (decreased) of HbA
2) Confidence 0.57 Published 2002 Journal Drugs Section Abstract Doc Link 12076188 Disease Relevance 0.72 Pain Relevance 0.18
In a randomised, double-blind, multicentre study, gliclazide MR 30 to 120 mg once daily showed similar efficacy to gliclazide immediate release (IR) 80 to 320 mg/day (in divided doses for doses >80 mg) in patients with type 2 diabetes mellitus over a 10-month period, reducing glycosylated haemoglobin (HbA(1c)) and fasting plasma glucose (FPG) to a similar extent.
Negative_regulation (reducing) of HbA in plasma associated with diabetes mellitus
3) Confidence 0.57 Published 2002 Journal Drugs Section Abstract Doc Link 12076188 Disease Relevance 0.29 Pain Relevance 0.08
CONCLUSION: Genuine magnetic field exposure has no advantage over sham exposure in reducing pain intensity, improving quality of life, and decreasing sleep disturbances and HbA(1c).


Negative_regulation (decreasing) of HbA
4) Confidence 0.57 Published 2008 Journal Diabetes Metab. Section Body Doc Link 18585071 Disease Relevance 0.05 Pain Relevance 0
In a post hoc analysis, ranolazine 750 and 1000 mg reduced HbA(1c) vs. placebo by 0.48+/-0.18% (P=0.008) and 0.70+/-0.18% (P=0.0002), respectively; the HbA(1c) levels appeared to remain unchanged over time during long-term therapy.
Negative_regulation (reduced) of HbA
5) Confidence 0.57 Published 2006 Journal Eur. Heart J. Section Body Doc Link 16176940 Disease Relevance 0 Pain Relevance 0
Both Na(V)1.2 and Na(V)1.6 were strongly blocked; within experimental wash times of 40-60 min, block was reversed very little for Na(V)1.2 and only partially for Na(V)1.6.
Negative_regulation (blocked) of Na(V)1.2
6) Confidence 0.57 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17724025 Disease Relevance 0.27 Pain Relevance 1.12
Inactivation of SCN1A and SCN2A [3] genes have been associated with epilepsy, SCN4A is associated with myotonia disorders [4], SCN5A is associated with Brugada syndrome (OMIM 601144) [5], which is characterized by cardiac arrhythmias in young people, and SCN8A is associated with cerebellar atrophy and ataxia [6].
Negative_regulation (Inactivation) of SCN2A associated with epilepsy, ataxia, frailty, heart arrhythmia and hypopituitarism
7) Confidence 0.55 Published 2010 Journal Dermatology (Basel, Switzerland) Section Body Doc Link PMC2969160 Disease Relevance 1.27 Pain Relevance 0.95
The results of the present study indicate that miglitol reduces fasting and postprandial plasma glucose levels, Improving glycaemic control, which is reflected in a reduced HbA(1C) level in patients with type 2 diabetes mellitus.
Negative_regulation (reduced) of HbA in plasma associated with diabetes mellitus
8) Confidence 0.42 Published 2007 Journal J Indian Med Assoc Section Abstract Doc Link 18232183 Disease Relevance 1.27 Pain Relevance 0.14
Rimonabant is a selective cannabinoid CB(1) receptor antagonist that produces a significant increase in insulin sensitivity and a reduction of HbA(1c) in diabetic patients.
Negative_regulation (reduction) of HbA associated with diabetes mellitus, antagonist and cannabinoid
9) Confidence 0.42 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20399204 Disease Relevance 1.10 Pain Relevance 0.63
Ranolazine significantly reduced HbA(1c) at 4 months compared with placebo (5.9% versus 6.2%; change from baseline, -0.30 versus -0.04; P<0.001).
Negative_regulation (reduced) of HbA
10) Confidence 0.42 Published 2009 Journal Circulation Section Body Doc Link 19349325 Disease Relevance 0.09 Pain Relevance 0
BACKGROUND: Ranolazine is a novel antianginal shown in an exploratory analysis in patients with diabetes mellitus and chronic angina to be associated with a decline in hemoglobin A(1c) (HbA(1c)).
Negative_regulation (decline) of HbA associated with angina and diabetes mellitus
11) Confidence 0.42 Published 2009 Journal Circulation Section Abstract Doc Link 19349325 Disease Relevance 0.27 Pain Relevance 0.10
An anesthetic fluorocyclobutane (1-chloro-1,2,2-trifluorocyclobutane) also inhibited the Na(v)1.2 channel, whereas the nonanesthetic fluorocyclobutane (1,2-dichlorohexafluorocyclobutane) had no effect.
Negative_regulation (inhibited) of Na(v)1.2
12) Confidence 0.42 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14978193 Disease Relevance 0 Pain Relevance 0.22
After treatment at the end of 12 weeks mean reduction in fasting plasma glucose levels was 35.7% and 44.33% in postprandial plasma glucose levels while the mean HbA(1C) was significantly reduced by 0.88% (p<0.05).
Negative_regulation (reduced) of HbA in plasma
13) Confidence 0.42 Published 2007 Journal J Indian Med Assoc Section Abstract Doc Link 18232183 Disease Relevance 1.02 Pain Relevance 0.11
"Alanine-walk" and related analogs were synthesized and tested against both Na(V)1.2 and Na(V)1.4; replacement of Trp-8 resulted in reversible block of Na(V)1.2, whereas replacement of Lys-7, Trp-8, or Asp-11 yielded a more profound effect on the block of Na(V)1.4 than of Na(V)1.2.
Negative_regulation (block) of Na(V)1.2
14) Confidence 0.42 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17724025 Disease Relevance 0.22 Pain Relevance 1.02
Compounds were evaluated for their ability to block the tetrodotoxin-resistant sodium channel Na(v)1.8 (PN3) as well as the Na(v)1.2 and Na(v)1.5 subtypes.
Negative_regulation (block) of Na(v)1.2 associated with tetrodotoxin and sodium channel
15) Confidence 0.41 Published 2008 Journal Bioorg. Med. Chem. Section Abstract Doc Link 18501613 Disease Relevance 0.16 Pain Relevance 0.61
The I(Na2) was markedly reduced by lignocaine (lidocaine) and by low extracellular [Na(+)], but it was little affected by low and high extracellular [Ca(2+)].
Negative_regulation (reduced) of Na2 associated with lidocaine
16) Confidence 0.04 Published 2008 Journal Exp. Physiol. Section Abstract Doc Link 17993508 Disease Relevance 0 Pain Relevance 0.10
In beta0 thalassemia, homozygotes HbA is absent and HbF constitutes the 92-95% of the total Hb.
Negative_regulation (absent) of HbA associated with thalassemia
17) Confidence 0.02 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2893117 Disease Relevance 1.08 Pain Relevance 0

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