INT10353

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Context Info
Confidence 0.70
First Reported 1986
Last Reported 2011
Negated 0
Speculated 3
Reported most in Body
Documents 34
Total Number 37
Disease Relevance 21.84
Pain Relevance 3.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PGR) enzyme binding (PGR) DNA binding (PGR)
cell-cell signaling (PGR) cytoplasm (PGR) signal transduction (PGR)
Anatomy Link Frequency
myometrium 2
joints 1
node 1
endometrium 1
PGR (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 30 99.70 Very High Very High Very High
gABA 9 98.96 Very High Very High Very High
Pain 31 97.28 Very High Very High Very High
palliative 11 96.96 Very High Very High Very High
Gabapentin 7 96.58 Very High Very High Very High
carbamazepine 26 96.14 Very High Very High Very High
tolerance 7 92.80 High High
Inflammation 55 90.56 High High
lacosamide 7 90.44 High High
antiarrhythmic agent 1 89.60 High High
Disease Link Frequency Relevance Heat
Breast Cancer 671 100.00 Very High Very High Very High
Metastasis 113 99.88 Very High Very High Very High
Fatigue 23 99.84 Very High Very High Very High
Pressure Volume 2 Under Development 3 99.82 Very High Very High Very High
Cancer 748 99.76 Very High Very High Very High
Inflammatory Breast Neoplasms 120 99.62 Very High Very High Very High
Pneumonia 1 99.56 Very High Very High Very High
Ovarian Cancer 219 99.40 Very High Very High Very High
Convulsion 126 98.80 Very High Very High Very High
Disease 416 98.78 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The patient was found comatose and experienced repeated generalized tonic-clonic seizures, aspiration with subsequent pneumonia, hypotension, and an increase in PR interval.
Positive_regulation (increase) of PR associated with pressure volume 2 under development, convulsion, pneumonia and coma
1) Confidence 0.70 Published 2010 Journal Epilepsy Behav Section Abstract Doc Link 20171144 Disease Relevance 1.23 Pain Relevance 0.49
Both ER and PR content were significantly elevated in the proliferative phase of the cycle.
Positive_regulation (elevated) of PR
2) Confidence 0.64 Published 1986 Journal Clin Physiol Biochem Section Abstract Doc Link 3709038 Disease Relevance 0.24 Pain Relevance 0.07
Recent data suggest that labour is associated with an increase in PGR-C isoforms, probably mediated through the NFKB pathway [24].
Positive_regulation (increase) of PGR
3) Confidence 0.50 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892059 Disease Relevance 0.07 Pain Relevance 0.04
All 21 metastases were negative for ER and PR on immunohistochemistry.
Positive_regulation (negative) of PR associated with metastasis
4) Confidence 0.48 Published 1997 Journal J. Pathol. Section Abstract Doc Link 9349240 Disease Relevance 0.57 Pain Relevance 0.10
The specific objectives of the biomarker sub-studies were as follows:To confirm ER and PgR status in a central laboratory.
Positive_regulation (confirm) of PgR
5) Confidence 0.41 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001223 Disease Relevance 0.47 Pain Relevance 0
The results revealed that a) in comparison to the baseline (attention retraining without PR or break), both conditions, A and B, enabled the patient to cope effectively with the 45 minute training sessions without significant increase of complaints (muscular tension, excitement); b) attentional performance (complete test d2) raised up to the average over the whole ABAB experiment; c) attentional performance (tested before and after each phase with a third part of test d2) decreased under the break condition during the individual sessions, while it was unchanged under PR; d) attentional performance at the computer retraining programme ("Bild" by Rigling) partially increased under PR and slightly decreased under break condition; e) there was less excitement and less muscular tension under PR in comparison to the break condition; and f) pain in the joints and exhaustion (both measured with the GBB) were reduced significantly under PR, as opposed to a marked increased in the break condition.
Spec (partially) Positive_regulation (increased) of PR in joints associated with pain
6) Confidence 0.41 Published 1992 Journal Rehabilitation (Stuttg) Section Abstract Doc Link 1484999 Disease Relevance 0.23 Pain Relevance 0.16
Seroprevalence was 21% (148/693) >50 m from a carrier and increased to 32% (23/71) at 2–50 m (Prevalence ratio [PR]?
Positive_regulation (increased) of PR
7) Confidence 0.40 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2625436 Disease Relevance 1.02 Pain Relevance 0.05
Furthermore, we configured the reward returns in PR so that the mean and variance in rewards that subjects experienced in PR task were equal to what the subjects earned on the FR task (Figure 1D).
Positive_regulation (experienced) of PR
8) Confidence 0.38 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762366 Disease Relevance 0 Pain Relevance 0
PGR-C reside mainly in the cytosol of myometrial cells and it is thought that the increase in PGR-C/PGR-B ratio takes progesterone away from PGR-B leading to low PGR binding to nuclear chromatin in myometrium in labour [24,25].
Positive_regulation (increase) of PGR in myometrium
9) Confidence 0.33 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892059 Disease Relevance 0.08 Pain Relevance 0.04
PGR-C reside mainly in the cytosol of myometrial cells and it is thought that the increase in PGR-C/PGR-B ratio takes progesterone away from PGR-B leading to low PGR binding to nuclear chromatin in myometrium in labour [24,25].
Positive_regulation (increase) of PGR in myometrium
10) Confidence 0.33 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892059 Disease Relevance 0.08 Pain Relevance 0.04
We further excluded two trials that compared different duration or dose of PR without placebo or SbV control group [21],[22]; one trial that compared different MA regimens as an augmentation of the same topical PR regimen [23]; two trials that randomized lesions instead of patients [18],[24] (because certain local treatments may lead to improvement in untreated lesions in the same individual [25],[26]); and four trials that compared PR with second-line treatments such as pentamidine [4], ketoconazole [27], and photodynamic therapy [24],[28].
Positive_regulation (augmentation) of PR
11) Confidence 0.28 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2637543 Disease Relevance 0.12 Pain Relevance 0
In intact animals or humans, encainide increases the AH, PR, QRS, and H-V intervals while not affecting the sinus node cycle length or JT interval.
Positive_regulation (increases) of PR in node
12) Confidence 0.28 Published 1989 Journal Cardiovasc Drugs Ther Section Abstract Doc Link 2518680 Disease Relevance 0 Pain Relevance 0.04
/PR negative breast cancer.50 Further studies will be required to establish the value of ER?
Positive_regulation (required) of PR associated with breast cancer
13) Confidence 0.27 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.84 Pain Relevance 0
Ibandronate modified neither PgR baseline level nor the increase in PgR level induced by E2.
Positive_regulation (increase) of PgR
14) Confidence 0.25 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1413981 Disease Relevance 0 Pain Relevance 0
That both LTPOCs produce a hyperprogestational endometrial milieu is suggested by the observation of significantly high endometrial levels of the progesterone receptor (PR) isoforms PRA and PRB after administration of Norplant [24] as well as the injectable LTPOC, Provera [23], whereas PRA appears to mediate the long-term effects of LNG in the endometrium during intrauterine LNG contraception [6].
Positive_regulation (levels) of progesterone receptor in endometrium
15) Confidence 0.20 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1403781 Disease Relevance 0.05 Pain Relevance 0.07
With all the techniques applied, the three cell lines were found to be negative for both ER and PR.
Positive_regulation (negative) of PR
16) Confidence 0.17 Published 1997 Journal J. Pathol. Section Abstract Doc Link 9349240 Disease Relevance 0.58 Pain Relevance 0.08
Immunohistochemical evaluation was strongly positive for desmin and actin (Figure 3), oestrogen receptor (ER) and progesterone receptor (PR) (Figure 4), but negative for cytokeratin and EMA (Epithelial Membrane Antigen).
Positive_regulation (positive) of progesterone receptor
17) Confidence 0.16 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1481579 Disease Relevance 0.51 Pain Relevance 0
Immunohistochemical evaluation was strongly positive for desmin and actin (Figure 3), oestrogen receptor (ER) and progesterone receptor (PR) (Figure 4), but negative for cytokeratin and EMA (Epithelial Membrane Antigen).
Positive_regulation (positive) of PR
18) Confidence 0.16 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1481579 Disease Relevance 0.51 Pain Relevance 0
Clark and colleagues [9] showed that mitosin is a proliferation marker that correlates with high S-phase fraction and negative estrogen receptor (ER)/progesterone receptor (PR) status.
Positive_regulation (negative) of progesterone receptor
19) Confidence 0.16 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400674 Disease Relevance 0.42 Pain Relevance 0
Clark and colleagues [9] showed that mitosin is a proliferation marker that correlates with high S-phase fraction and negative estrogen receptor (ER)/progesterone receptor (PR) status.
Positive_regulation (negative) of PR
20) Confidence 0.16 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400674 Disease Relevance 0.42 Pain Relevance 0

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