INT103531

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Context Info
Confidence 0.61
First Reported 2002
Last Reported 2004
Negated 3
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.31
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gad1) lyase activity (Gad1) intracellular (Gad1)
cytoplasm (Gad1)
Anatomy Link Frequency
substantia nigra pars reticulata 2
striatum 2
globus pallidus 2
Gad1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 15 100.00 Very High Very High Very High
Substantia nigra 3 100.00 Very High Very High Very High
gABA 2 100.00 Very High Very High Very High
Glutamate 2 100.00 Very High Very High Very High
substance P 2 100.00 Very High Very High Very High
Enkephalin 6 96.70 Very High Very High Very High
Neuropeptide 9 95.52 Very High Very High Very High
Neurotransmitter 1 81.48 Quite High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 2 100.00 Very High Very High Very High
Parkinson's Disease 2 71.88 Quite High
Disease 1 71.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thalamic lesions prevented most of the dopamine denervation-induced changes (i.e. the increases in mRNA levels of enkephalin and GAD67 in the striatum, of GAD67 in the globus pallidus and entopeduncular nucleus, and of cytochrome oxidase subunit-I in the subthalamic nucleus), but did not affect the downregulation of striatal substance P and upregulation of GAD67 in the substantia nigra pars reticulata.
Neg (not) Regulation (affect) of Positive_regulation (upregulation) of GAD67 in substantia nigra pars reticulata associated with dopamine, substantia nigra, enkephalin and substance p
1) Confidence 0.61 Published 2004 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 14748558 Disease Relevance 0.07 Pain Relevance 0.39
The lesion-induced increases in intraneuronal glutamate decarboxylase 67 kDa isoform (GAD67) mRNA levels on the lesion side were reversed by STN HFS in the substantia nigra, partially antagonized in the entopeduncular nucleus but unaffected in the globus pallidus.
Neg (unaffected) Regulation (unaffected) of Positive_regulation (increases) of GAD67 in globus pallidus associated with glutamate and substantia nigra
2) Confidence 0.60 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12077209 Disease Relevance 0.07 Pain Relevance 0.53
In rats with multiple intrastriatal VM transplants the lesion-induced upregulation of mRNAs encoding for preproenkephalin (PPE), the D(2)-type DA-receptor, and the GABA-synthesizing enzyme glutamic acid decarboxylase (GAD(67)) was normalized throughout the striatum, whereas the lesion-induced downregulation of preprotachykinin mRNA was unaffected.
Neg (unaffected) Regulation (unaffected) of Positive_regulation (upregulation) of GABA-synthesizing enzyme glutamic acid decarboxylase in striatum associated with gaba, dopamine and generalized anxiety disorder
3) Confidence 0.35 Published 2003 Journal Neuroscience Section Abstract Doc Link 12732251 Disease Relevance 0.17 Pain Relevance 0.50

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