INT103547

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 2002
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 47
Total Number 48
Disease Relevance 17.06
Pain Relevance 13.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
skin 5
keratinocytes 5
spinal cord 3
leukocytes 3
brain 2
TRPV3 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 284 100.00 Very High Very High Very High
Spinal cord 162 99.84 Very High Very High Very High
dorsal root ganglion 429 99.60 Very High Very High Very High
Pain 534 99.56 Very High Very High Very High
Root ganglion neuron 3 99.56 Very High Very High Very High
Dorsal horn 14 98.86 Very High Very High Very High
Central nervous system 21 98.68 Very High Very High Very High
diabetic neuropathy 104 98.64 Very High Very High Very High
agonist 63 98.40 Very High Very High Very High
trigeminal ganglion 13 98.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 26 100.00 Very High Very High Very High
Ganglion Cysts 459 99.60 Very High Very High Very High
Pain 407 99.56 Very High Very High Very High
Liver Cancer 2 98.88 Very High Very High Very High
Diabetic Neuropathy 104 98.64 Very High Very High Very High
Injury 260 97.40 Very High Very High Very High
Frailty 13 97.40 Very High Very High Very High
Diabetes Mellitus 333 95.90 Very High Very High Very High
Neuropathic Pain 197 94.20 High High
Pruritus 8 93.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present investigation TRPV3 was transiently expressed in either Xenopus oocytes or HEK293 cells.
Gene_expression (expressed) of TRPV3 in oocytes
1) Confidence 0.78 Published 2009 Journal J Pharm Pharm Sci Section Abstract Doc Link 19470296 Disease Relevance 0.09 Pain Relevance 0.22
TRPV3 was present in ventral but not dorsal roots, in contrast, TRPV1 was present in dorsal but negligible in ventral roots.
Gene_expression (present) of TRPV3 in ventral roots
2) Confidence 0.72 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 0.64 Pain Relevance 0.23
TRPV3 and TRPV1 are present not only in DRG sensory neurons but also in various regions of the central nervous system and non-neuronal tissue [5,27].
Gene_expression (present) of TRPV3 in neuronal associated with dorsal root ganglion and central nervous system
3) Confidence 0.72 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 1.06 Pain Relevance 0.61
TRPV3 was classified as the least expressed gene of the pool, followed by TRPV1 and TRPV4 (respectively 2.28 and 4.83 times more expressed than TRPV3).
Gene_expression (expressed) of TRPV3
4) Confidence 0.67 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588574 Disease Relevance 0.08 Pain Relevance 0.08
According to the results for the 30 healthy donors, we can conclude that TRPV3 is the least expressed gene of this pool, followed by TRPV4, TRPV1 and TRPV2 (Fig. 1).
Gene_expression (expressed) of TRPV3
5) Confidence 0.67 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588574 Disease Relevance 0 Pain Relevance 0
VRL3 responds to noxious heat with a threshold of about 39 degrees C and is co-expressed in dorsal root ganglion neurons with VR1.
Gene_expression (co-expressed) of VRL3 in neurons associated with ganglion cysts and root ganglion neuron
6) Confidence 0.65 Published 2002 Journal Nature Section Abstract Doc Link 12077606 Disease Relevance 0.18 Pain Relevance 0.45
Furthermore, when heterologously expressed, VRL3 is able to associate with VR1 and may modulate its responses.
Gene_expression (expressed) of VRL3
7) Confidence 0.65 Published 2002 Journal Nature Section Abstract Doc Link 12077606 Disease Relevance 0.17 Pain Relevance 0.41
TRPV1-immunoreactive fibres were detected in distal peripheral nerve and were present in fine fibres in control skin up to and including the epidermis, whilst TRPV3-immunoreactivity in fibres was relatively weak in the nerve trunk and undetectable at the skin level but was present in basal keratinocytes (see below).
Gene_expression (present) of TRPV3-immunoreactivity in keratinocytes
8) Confidence 0.62 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 0.69 Pain Relevance 0.07
We have shown previously and confirmed in this study that TRPV1 and TRPV3 were present in human DRG neurons, mostly of small/medium diameter, and that the number of positive cells increased after DRG avulsion injury [4].


Gene_expression (present) of TRPV3 in neurons associated with dorsal root ganglion and injury
9) Confidence 0.62 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 0.63 Pain Relevance 0.26
TRPV1-immunoreactive fibres were detected in distal peripheral nerve and were present in fine fibres in control skin up to and including the epidermis, whilst TRPV3-immunoreactivity in fibres was relatively weak in the nerve trunk and undetectable at the skin level but was present in basal keratinocytes (see below).
Gene_expression (undetectable) of TRPV3-immunoreactivity in keratinocytes
10) Confidence 0.62 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 0.69 Pain Relevance 0.07
There was a clear difference in the distribution of TRPV3 and TRPV1 in spinal nerve roots.
Gene_expression (distribution) of TRPV3 in spinal nerve
11) Confidence 0.62 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 0.65 Pain Relevance 0.24
Here we have identified a member of the vanilloid channel family, human TRPV3 (hTRPV3) that is expressed in skin, tongue, dorsal root ganglion, trigeminal ganglion, spinal cord and brain.
Gene_expression (expressed) of TRPV3 in trigeminal ganglion associated with ganglion cysts, dorsal root ganglion, trigeminal ganglion and spinal cord
12) Confidence 0.62 Published 2002 Journal Nature Section Abstract Doc Link 12077604 Disease Relevance 0.20 Pain Relevance 0.27
In inside-out membrane patches from TRPV3-expressing cells, 2-APB increases the open probability of TRPV3.
Gene_expression (expressing) of TRPV3
13) Confidence 0.62 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15175387 Disease Relevance 0.08 Pain Relevance 0.08
No nonthermal stimuli have yet been described for TRPV3, a warmth-gated ion channel expressed prominently in skin keratinocytes.
Gene_expression (expressed) of TRPV3 in keratinocytes associated with increased venous pressure under development
14) Confidence 0.62 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15175387 Disease Relevance 0.10 Pain Relevance 0.09
PURPOSE: Transient receptor potential vanilloid-3 (TRPV3) is a thermo-sensitive ion channel expressed in skin keratinocytes and in a variety of neural cells.
Gene_expression (expressed) of TRPV3 in neural
15) Confidence 0.60 Published 2009 Journal J Pharm Pharm Sci Section Abstract Doc Link 19470296 Disease Relevance 0.09 Pain Relevance 0.19
PURPOSE: Transient receptor potential vanilloid-3 (TRPV3) is a thermo-sensitive ion channel expressed in skin keratinocytes and in a variety of neural cells.
Gene_expression (expressed) of vanilloid-3 in neural
16) Confidence 0.60 Published 2009 Journal J Pharm Pharm Sci Section Abstract Doc Link 19470296 Disease Relevance 0.09 Pain Relevance 0.19
Long-term exposure to camphor and 1,8-cineol elicits desensitizing currents in TRPV3 expressing oocytes, whereas the non-terpenoid agonist 2-APB induces sustained currents.
Gene_expression (expressing) of TRPV3 in oocytes
17) Confidence 0.60 Published 2009 Journal J Pharm Pharm Sci Section Body Doc Link 19470296 Disease Relevance 0 Pain Relevance 0
TRPV3 was classified as the least expressed gene of the pool, followed by TRPV1 and TRPV4 (respectively 2.28 and 4.83 times more expressed than TRPV3).
Gene_expression (expressed) of TRPV3
18) Confidence 0.58 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588574 Disease Relevance 0.08 Pain Relevance 0.08
Diabetic epidermis is known to be abnormally thin, so the trend we describe for decrease of TRPV3 in keratinocytes, may be related to changes of neurotrophins or other factors controlling skin differentiation and TRPV3 expression.
Gene_expression (expression) of TRPV3 in skin associated with diabetes mellitus
19) Confidence 0.56 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 0.63 Pain Relevance 0.09
We previously reported that human dorsal root ganglion (DRG) sensory neurons co-expressed TRPV1 and TRPV3, and that these were increased in injured human DRG.
Gene_expression (expressed) of TRPV3 in sensory neurons associated with ganglion cysts and dorsal root ganglion
20) Confidence 0.56 Published 2007 Journal BMC Neurol Section Abstract Doc Link PMC1892784 Disease Relevance 0.79 Pain Relevance 0.33

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox