INT103548

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Context Info
Confidence 0.37
First Reported 2002
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.82
Pain Relevance 2.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TRPV1) transport (TRPV1) plasma membrane (TRPV1)
lipid metabolic process (TRPV1)
TRPV1 (Homo sapiens)
TRPV3 (Homo sapiens)
Pain Link Frequency Relevance Heat
burning pain 2 99.16 Very High Very High Very High
Root ganglion neuron 1 97.80 Very High Very High Very High
bradykinin 6 94.88 High High
IPN 7 94.24 High High
Inflammatory mediators 7 94.00 High High
qutenza 19 91.48 High High
Pain 105 87.56 High High
dorsal root ganglion 41 84.96 Quite High
TRP channel 3 84.76 Quite High
Hyperalgesia 12 83.72 Quite High
Disease Link Frequency Relevance Heat
Pain 128 99.16 Very High Very High Very High
Ganglion Cysts 43 97.48 Very High Very High Very High
Osteoarthritis 1 97.04 Very High Very High Very High
Inflammatory Pain 7 94.24 High High
INFLAMMATION 42 93.60 High High
Hyperalgesia 14 83.72 Quite High
Injury 30 73.84 Quite High
Nociception 13 72.36 Quite High
Nervous System Injury 22 61.84 Quite High
Shock 1 55.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although vanilloid receptors are known to exist and function as homomers [15,16], some evidence has been provided for the biochemical association of TRPV3 and TRPV1 suggesting heteromerization [17], thus allowing a greater range of receptor characteristics.
TRPV1 Binding (association) of TRPV3
1) Confidence 0.37 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 0.58 Pain Relevance 0.68
Furthermore, when heterologously expressed, VRL3 is able to associate with VR1 and may modulate its responses.
VR1 Binding (associate) of VRL3
2) Confidence 0.35 Published 2002 Journal Nature Section Abstract Doc Link 12077606 Disease Relevance 0.17 Pain Relevance 0.41
In addition, TRPV1 can oligomerize with other TRP family members, including TRPV3.
TRPV1 Binding (oligomerize) of TRPV3
3) Confidence 0.11 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 1.07 Pain Relevance 1.19

General Comments

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