INT103550

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Context Info
Confidence 0.44
First Reported 2002
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.41
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 1
peripheral nerve 1
TRPV3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Root ganglion neuron 2 97.80 Very High Very High Very High
qutenza 24 93.88 High High
dorsal root ganglion 64 84.16 Quite High
Pain 34 76.52 Quite High
Thermal hyperalgesia 2 65.84 Quite High
Eae 2 43.84 Quite Low
Neuropeptide 2 31.36 Quite Low
substance P 2 30.24 Quite Low
sodium channel 6 23.60 Low Low
Spinal cord 22 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 68 97.48 Very High Very High Very High
Nervous System Injury 18 87.68 High High
Injury 40 83.68 Quite High
Nociception 8 79.36 Quite High
Pain 20 76.52 Quite High
Hyperalgesia 6 65.84 Quite High
Neuropathic Pain 30 44.52 Quite Low
Hypersensitivity 6 42.80 Quite Low
Diabetes Mellitus 50 5.00 Very Low Very Low Very Low
Diabetic Neuropathy 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although vanilloid receptors are known to exist and function as homomers [15,16], some evidence has been provided for the biochemical association of TRPV3 and TRPV1 suggesting heteromerization [17], thus allowing a greater range of receptor characteristics.
TRPV3 Binding (association) of
1) Confidence 0.44 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 0.58 Pain Relevance 0.68
In control, uninjured peripheral nerve, immunoreactivity for TRPV1 (Fig 3A), TRPV3 (Fig 3C), and TRPV4 (Fig. 3E) was detected in fine to medium calibre fibres with TRPV3 immunoreactivity less intense than that for TRPV1 or TRPV4.
TRPV3 Binding (immunoreactivity) of in peripheral nerve
2) Confidence 0.33 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 0.49 Pain Relevance 0.08
VRL3 responds to noxious heat with a threshold of about 39 degrees C and is co-expressed in dorsal root ganglion neurons with VR1.
VRL3 Binding (responds) of in neurons associated with ganglion cysts and root ganglion neuron
3) Confidence 0.31 Published 2002 Journal Nature Section Abstract Doc Link 12077606 Disease Relevance 0.18 Pain Relevance 0.45
Furthermore, when heterologously expressed, VRL3 is able to associate with VR1 and may modulate its responses.
VRL3 Binding (associate) of
4) Confidence 0.30 Published 2002 Journal Nature Section Abstract Doc Link 12077606 Disease Relevance 0.17 Pain Relevance 0.41

General Comments

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