INT103550

Context Info Confidence 0.44 First Reported 2002 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 4 Disease Relevance 1.41 Pain Relevance 1.61

Anatomy Link Frequency neurons 1 peripheral nerve 1 TRPV3 (Homo sapiens)

Pain Link Frequency Relevance Heat Root ganglion neuron 2 97.80 qutenza 24 93.88 dorsal root ganglion 64 84.16 Pain 34 76.52 Thermal hyperalgesia 2 65.84 Eae 2 43.84 Neuropeptide 2 31.36 substance P 2 30.24 sodium channel 6 23.60 Spinal cord 22 5.00

Disease Link Frequency Relevance Heat Ganglion Cysts 68 97.48 Nervous System Injury 18 87.68 Injury 40 83.68 Nociception 8 79.36 Pain 20 76.52 Hyperalgesia 6 65.84 Neuropathic Pain 30 44.52 Hypersensitivity 6 42.80 Diabetes Mellitus 50 5.00 Diabetic Neuropathy 16 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Although vanilloid receptors are known to exist and function as homomers [15,16], some evidence has been provided for the biochemical association of TRPV3 and TRPV1 suggesting heteromerization [17], thus allowing a greater range of receptor characteristics.

TRPV3 Binding (association) of

1) Confidence 0.44 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 0.58 Pain Relevance 0.68

In control, uninjured peripheral nerve, immunoreactivity for TRPV1 (Fig 3A), TRPV3 (Fig 3C), and TRPV4 (Fig. 3E) was detected in fine to medium calibre fibres with TRPV3 immunoreactivity less intense than that for TRPV1 or TRPV4.

TRPV3 Binding (immunoreactivity) of in peripheral nerve

2) Confidence 0.33 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 0.49 Pain Relevance 0.08

VRL3 responds to noxious heat with a threshold of about 39 degrees C and is co-expressed in dorsal root ganglion neurons with VR1.

VRL3 Binding (responds) of in neurons associated with ganglion cysts and root ganglion neuron

3) Confidence 0.31 Published 2002 Journal Nature Section Abstract Doc Link 12077606 Disease Relevance 0.18 Pain Relevance 0.45

Furthermore, when heterologously expressed, VRL3 is able to associate with VR1 and may modulate its responses.

VRL3 Binding (associate) of

4) Confidence 0.30 Published 2002 Journal Nature Section Abstract Doc Link 12077606 Disease Relevance 0.17 Pain Relevance 0.41

General Comments

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