INT10357

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Context Info
Confidence 0.37
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 8.95
Pain Relevance 8.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Syncrip) RNA binding (Syncrip) nucleus (Syncrip)
cytoplasm (Syncrip)
Anatomy Link Frequency
Shoulder 1
neurons 1
muscle 1
Arm 1
median nerve 1
Syncrip (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 599 100.00 Very High Very High Very High
abdominal pain 8 100.00 Very High Very High Very High
Quantitative sensory testing 28 99.22 Very High Very High Very High
depression 5 98.90 Very High Very High Very High
fibrosis 12 97.12 Very High Very High Very High
shoulder pain 6 94.00 High High
Hippocampus 24 93.76 High High
Lasting pain 6 90.08 High High
Neuropathic pain 46 88.56 High High
Sciatica 45 87.32 High High
Disease Link Frequency Relevance Heat
Pain 582 100.00 Very High Very High Very High
Abdominal Pain 8 100.00 Very High Very High Very High
Anxiety Disorder 2 99.38 Very High Very High Very High
Neuropathic Pain 93 99.32 Very High Very High Very High
Depression 5 98.90 Very High Very High Very High
Fibrosis 12 97.12 Very High Very High Very High
Frailty 9 96.40 Very High Very High Very High
Shoulder Pain 6 94.00 High High
Targeted Disruption 78 93.04 High High
Nerve Root Compression 49 87.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, the group of subjects with LE actually showed increases in MUP size relative to the control subjects, suggesting that the neuromuscular changes seen in individuals with NSAP are not the same as those seen in individuals with LE.
NSAP Binding (individuals) of associated with pain
1) Confidence 0.37 Published 2008 Journal J Neuroeng Rehabil Section Body Doc Link PMC2654455 Disease Relevance 0.79 Pain Relevance 0.66
In addition, all of the SMUP parameters were significantly smaller in the NSAP group, further supporting the suggestion that NSAP may be associated with changes within the muscle itself such as a loss of muscle fibers, fibrosis [17], or atrophy.
NSAP Binding (associated) of in muscle associated with fibrosis, pain and frailty
2) Confidence 0.37 Published 2008 Journal J Neuroeng Rehabil Section Body Doc Link PMC2654455 Disease Relevance 0.87 Pain Relevance 0.73
Because our goal was to characterize individuals with NSAP separately from LE, we did not include any subjects who had signs or symptoms that could be attributed to both LE and NSAP.
NSAP Binding (individuals) of associated with pain
3) Confidence 0.37 Published 2008 Journal J Neuroeng Rehabil Section Body Doc Link PMC2654455 Disease Relevance 1.03 Pain Relevance 0.96
After 2 years, patients with continuing pain had higher HAD and Spielberger Anxiety Trait scores (both P < 0.02); NSAP was associated with persisting pain (relative risk 2.22 (95 per cent c.i. 1.10-4.48)).
NSAP Binding (associated) of associated with pain, abdominal pain, depression and anxiety disorder
4) Confidence 0.34 Published 1992 Journal Br J Surg Section Abstract Doc Link 1486444 Disease Relevance 1.44 Pain Relevance 1.14
Of particular interest among these genes was the gene Syncrip, the protein product of which has been identified to be associated with dendrites of neurons where it assists localized protein synthesis near synapses, possibly in response to incoming stimuli in neurons [48,49].
Syncrip Binding (associated) of in neurons
5) Confidence 0.28 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.28 Pain Relevance 0.05
The objectives of this study are to:

• Describe the somatosensory profiles of subjects with NSAP in terms of neurological examination, qualitative measures of pain, neural tissue provocation tests and QST. • Describe impairment and disability associated with NSAP by means of the Disabilities of the Arm, Shoulder and Hand (DASH) and SF-36 questionnaires. • Investigate for correlations between clinical examination findings, QST profiles and questionnaire derived pain profiles in subjects with NSAP. • Compare somatosensory profiles of subjects with NSAP to those with cervical radiculopathy and asymptomatic controls.


NSAP Binding (associated) of in Shoulder associated with nerve root compression, quantitative sensory testing, pain and sciatica
6) Confidence 0.28 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2825226 Disease Relevance 1.78 Pain Relevance 1.77
The painful symptoms often associated with NSAP suggest a minor neuropathy involving at least in part the median nerve [4].
NSAP Binding (associated) of in median nerve associated with pain and neuropathic pain
7) Confidence 0.20 Published 2004 Journal BMC Musculoskelet Disord Section Body Doc Link PMC503391 Disease Relevance 0.98 Pain Relevance 1.00
The objectives of this study are to:

• Describe the somatosensory profiles of subjects with NSAP in terms of neurological examination, qualitative measures of pain, neural tissue provocation tests and QST. • Describe impairment and disability associated with NSAP by means of the Disabilities of the Arm, Shoulder and Hand (DASH) and SF-36 questionnaires. • Investigate for correlations between clinical examination findings, QST profiles and questionnaire derived pain profiles in subjects with NSAP. • Compare somatosensory profiles of subjects with NSAP to those with cervical radiculopathy and asymptomatic controls.


NSAP Binding (associated) of in Arm associated with nerve root compression, quantitative sensory testing, pain and sciatica
8) Confidence 0.09 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2825226 Disease Relevance 1.78 Pain Relevance 1.77

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