INT10357

Context Info Confidence 0.37 First Reported 1992 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 8 Total Number 8 Disease Relevance 8.95 Pain Relevance 8.07

mRNA processing (Syncrip) RNA binding (Syncrip) nucleus (Syncrip) cytoplasm (Syncrip)

Anatomy Link Frequency Shoulder 1 neurons 1 muscle 1 Arm 1 median nerve 1 Syncrip (Mus musculus)

Pain Link Frequency Relevance Heat Pain 599 100.00 abdominal pain 8 100.00 Quantitative sensory testing 28 99.22 depression 5 98.90 fibrosis 12 97.12 shoulder pain 6 94.00 Hippocampus 24 93.76 Lasting pain 6 90.08 Neuropathic pain 46 88.56 Sciatica 45 87.32

Disease Link Frequency Relevance Heat Pain 582 100.00 Abdominal Pain 8 100.00 Anxiety Disorder 2 99.38 Neuropathic Pain 93 99.32 Depression 5 98.90 Fibrosis 12 97.12 Frailty 9 96.40 Shoulder Pain 6 94.00 Targeted Disruption 78 93.04 Nerve Root Compression 49 87.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Interestingly, the group of subjects with LE actually showed increases in MUP size relative to the control subjects, suggesting that the neuromuscular changes seen in individuals with NSAP are not the same as those seen in individuals with LE.

NSAP Binding (individuals) of associated with pain

1) Confidence 0.37 Published 2008 Journal J Neuroeng Rehabil Section Body Doc Link PMC2654455 Disease Relevance 0.79 Pain Relevance 0.66

In addition, all of the SMUP parameters were significantly smaller in the NSAP group, further supporting the suggestion that NSAP may be associated with changes within the muscle itself such as a loss of muscle fibers, fibrosis [17], or atrophy.

NSAP Binding (associated) of in muscle associated with fibrosis, pain and frailty

2) Confidence 0.37 Published 2008 Journal J Neuroeng Rehabil Section Body Doc Link PMC2654455 Disease Relevance 0.87 Pain Relevance 0.73

Because our goal was to characterize individuals with NSAP separately from LE, we did not include any subjects who had signs or symptoms that could be attributed to both LE and NSAP.

NSAP Binding (individuals) of associated with pain

3) Confidence 0.37 Published 2008 Journal J Neuroeng Rehabil Section Body Doc Link PMC2654455 Disease Relevance 1.03 Pain Relevance 0.96

After 2 years, patients with continuing pain had higher HAD and Spielberger Anxiety Trait scores (both P < 0.02); NSAP was associated with persisting pain (relative risk 2.22 (95 per cent c.i. 1.10-4.48)).

NSAP Binding (associated) of associated with pain, abdominal pain, depression and anxiety disorder

4) Confidence 0.34 Published 1992 Journal Br J Surg Section Abstract Doc Link 1486444 Disease Relevance 1.44 Pain Relevance 1.14

Of particular interest among these genes was the gene Syncrip, the protein product of which has been identified to be associated with dendrites of neurons where it assists localized protein synthesis near synapses, possibly in response to incoming stimuli in neurons [48,49].

Syncrip Binding (associated) of in neurons

5) Confidence 0.28 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.28 Pain Relevance 0.05

The objectives of this study are to: • Describe the somatosensory profiles of subjects with NSAP in terms of neurological examination, qualitative measures of pain, neural tissue provocation tests and QST. • Describe impairment and disability associated with NSAP by means of the Disabilities of the Arm, Shoulder and Hand (DASH) and SF-36 questionnaires. • Investigate for correlations between clinical examination findings, QST profiles and questionnaire derived pain profiles in subjects with NSAP. • Compare somatosensory profiles of subjects with NSAP to those with cervical radiculopathy and asymptomatic controls.

NSAP Binding (associated) of in Shoulder associated with nerve root compression, quantitative sensory testing, pain and sciatica

6) Confidence 0.28 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2825226 Disease Relevance 1.78 Pain Relevance 1.77

The painful symptoms often associated with NSAP suggest a minor neuropathy involving at least in part the median nerve [4].

NSAP Binding (associated) of in median nerve associated with pain and neuropathic pain

7) Confidence 0.20 Published 2004 Journal BMC Musculoskelet Disord Section Body Doc Link PMC503391 Disease Relevance 0.98 Pain Relevance 1.00

The objectives of this study are to: • Describe the somatosensory profiles of subjects with NSAP in terms of neurological examination, qualitative measures of pain, neural tissue provocation tests and QST. • Describe impairment and disability associated with NSAP by means of the Disabilities of the Arm, Shoulder and Hand (DASH) and SF-36 questionnaires. • Investigate for correlations between clinical examination findings, QST profiles and questionnaire derived pain profiles in subjects with NSAP. • Compare somatosensory profiles of subjects with NSAP to those with cervical radiculopathy and asymptomatic controls.

NSAP Binding (associated) of in Arm associated with nerve root compression, quantitative sensory testing, pain and sciatica

8) Confidence 0.09 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2825226 Disease Relevance 1.78 Pain Relevance 1.77

General Comments

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