INT10359

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Context Info
Confidence 0.78
First Reported 1989
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 159
Total Number 160
Disease Relevance 79.60
Pain Relevance 72.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ifng) extracellular region (Ifng)
Anatomy Link Frequency
T cells 17
NK cell 10
lymphocyte 8
lymph node 7
plasma 6
Ifng (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 281 100.00 Very High Very High Very High
Inflammation 280 100.00 Very High Very High Very High
antagonist 78 100.00 Very High Very High Very High
nociceptor 15 100.00 Very High Very High Very High
Pain 94 99.92 Very High Very High Very High
Angina 37 99.88 Very High Very High Very High
fluoxetine 20 99.84 Very High Very High Very High
nud 4 99.84 Very High Very High Very High
cINOD 22 99.80 Very High Very High Very High
Sciatic nerve 18 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 303 100.00 Very High Very High Very High
Cancer 33 100.00 Very High Very High Very High
Necrosis 20 100.00 Very High Very High Very High
Pain 86 99.92 Very High Very High Very High
Cv General 3 Under Development 37 99.88 Very High Very High Very High
Immunization 66 99.84 Very High Very High Very High
Dyspepsia 4 99.84 Very High Very High Very High
Pancreatitis 18 99.80 Very High Very High Very High
Recurrence 10 99.68 Very High Very High Very High
Experimental Autoimmune Neuritis 271 99.66 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Splenocytes of Intact females showed higher IFN-gamma production than those of Intact males.
Gene_expression (production) of IFN-gamma
1) Confidence 0.78 Published 2001 Journal Brain Behav. Immun. Section Abstract Doc Link 11566050 Disease Relevance 0.15 Pain Relevance 0.21
The present data demonstrate a sex difference in IFN-gamma production (due to the immunostimulating effect of estradiol in females) and an immunodepressive role of pain in both sexes.
Gene_expression (production) of IFN-gamma associated with pain
2) Confidence 0.78 Published 2001 Journal Brain Behav. Immun. Section Abstract Doc Link 11566050 Disease Relevance 0.23 Pain Relevance 0.23
Effects of gonadectomy and pain on interferon-gamma production in splenocytes of male and female rats.
Gene_expression (production) of interferon-gamma associated with pain
3) Confidence 0.78 Published 2001 Journal Brain Behav. Immun. Section Title Doc Link 11566050 Disease Relevance 0.20 Pain Relevance 0.30
The role of gonadal hormones and persistent pain (formalin test) in the regulation of interferon-gamma (IFN-gamma) production in splenocytes was investigated in male and female rats.
Gene_expression (production) of IFN-gamma in gonadal associated with pain and lasting pain
4) Confidence 0.78 Published 2001 Journal Brain Behav. Immun. Section Abstract Doc Link 11566050 Disease Relevance 0.17 Pain Relevance 0.17
The role of gonadal hormones and persistent pain (formalin test) in the regulation of interferon-gamma (IFN-gamma) production in splenocytes was investigated in male and female rats.
Gene_expression (production) of interferon-gamma in gonadal associated with pain and lasting pain
5) Confidence 0.78 Published 2001 Journal Brain Behav. Immun. Section Abstract Doc Link 11566050 Disease Relevance 0.17 Pain Relevance 0.17
IFN-gamma production was determined in vitro in the splenocytes after Con A stimulation.
Gene_expression (production) of IFN-gamma
6) Confidence 0.78 Published 2001 Journal Brain Behav. Immun. Section Abstract Doc Link 11566050 Disease Relevance 0.15 Pain Relevance 0.21
In females, there was a positive correlation between IFN-gamma production in splenocytes and plasma estradiol levels.
Gene_expression (production) of IFN-gamma in plasma
7) Confidence 0.78 Published 2001 Journal Brain Behav. Immun. Section Abstract Doc Link 11566050 Disease Relevance 0.14 Pain Relevance 0.22
Chronically stressed rats also exhibited anxiety-like behaviors, enhanced fecal pellet excretion, and small but significant increases in the mast cell numbers and the expression of IL-1beta and IFN-gamma.
Gene_expression (expression) of IFN-gamma in mast cell associated with anxiety disorder
8) Confidence 0.78 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15746211 Disease Relevance 1.57 Pain Relevance 0.25
The proinflammatory cytokine interferon-gamma (IFN-gamma), which can be present in elevated levels in the central nervous system during pathological conditions, may be involved in the generation of persistent pain states by inducing neuronal hyperexcitability.
Gene_expression (present) of IFN-gamma in central nervous system associated with pain, lasting pain, central nervous system, hyperexcitability and cytokine
9) Confidence 0.78 Published 2007 Journal Pain Section Abstract Doc Link 17407800 Disease Relevance 0.09 Pain Relevance 0.52
A single, acute injection of morphine did not suppress NK cell activity in rats that drank the two highest concentrations of morphine, whereas it did suppress the mitogen-stimulated splenic T- and B-cell proliferation and gamma-IFN production.
Gene_expression (production) of gamma-IFN in B-cell associated with morphine
10) Confidence 0.78 Published 1997 Journal Drug Alcohol Depend Section Abstract Doc Link 9250473 Disease Relevance 0.08 Pain Relevance 1.15
In contrast, proliferation of splenic T and B cells and interferon-gamma production are not altered within 30 min; maximal suppression occurs at 1 h, and recovery begins within 2 h.
Gene_expression (production) of interferon-gamma in B cells
11) Confidence 0.78 Published 1997 Journal Anesth. Analg. Section Abstract Doc Link 9296419 Disease Relevance 0 Pain Relevance 1.39
Expression of interferon-gamma in the lens exacerbates anterior uveitis and induces retinal degenerative changes in transgenic Lewis rats.
Gene_expression (Expression) of interferon-gamma in lens associated with targeted disruption and uveitis
12) Confidence 0.78 Published 1999 Journal Clin. Immunol. Section Title Doc Link 10227812 Disease Relevance 1.30 Pain Relevance 0.17
In this study, we generated transgenic rats with constitutive expression of IFN-gamma in the eye to study its paracrine effects and to investigate whether local production of IFN-gamma also confers protection against uveitis in the rat species.
Gene_expression (expression) of IFN-gamma in eye associated with targeted disruption and uveitis
13) Confidence 0.78 Published 1999 Journal Clin. Immunol. Section Abstract Doc Link 10227812 Disease Relevance 1.44 Pain Relevance 0.17
In this study, we generated transgenic rats with constitutive expression of IFN-gamma in the eye to study its paracrine effects and to investigate whether local production of IFN-gamma also confers protection against uveitis in the rat species.
Gene_expression (production) of IFN-gamma in eye associated with targeted disruption and uveitis
14) Confidence 0.78 Published 1999 Journal Clin. Immunol. Section Abstract Doc Link 10227812 Disease Relevance 1.45 Pain Relevance 0.19
The morphine injection suppressed measures of splenic natural killer (NK) cell activity, mitogen-stimulated T-cell proliferation, and gamma-interferon (IFN) production in rats that received saline via the minipump.
Gene_expression (production) of gamma-interferon in T-cell associated with morphine
15) Confidence 0.77 Published 1998 Journal Drug Alcohol Depend Section Abstract Doc Link 10933338 Disease Relevance 0 Pain Relevance 0.84
In rats that received chronic morphine via the minipump, the morphine injection also suppressed mitogen-stimulated splenocyte proliferation and gamma-IFN production but did not suppress NK cell activity.
Gene_expression (production) of gamma-IFN in NK cell associated with morphine
16) Confidence 0.77 Published 1998 Journal Drug Alcohol Depend Section Abstract Doc Link 10933338 Disease Relevance 0 Pain Relevance 0.89
Indeed, formalin injection per se decreased IFN-gamma production; estradiol had no effect on sham-injected animals but strongly reduce the decrease of IFN-gamma production in formalin-injected animals.
Gene_expression (production) of IFN-gamma
17) Confidence 0.77 Published 2004 Journal Pain Section Abstract Doc Link 15327822 Disease Relevance 0.26 Pain Relevance 0.54
The spontaneous behaviours, pain-related behaviours and interferon-gamma (IFN-gamma) production by peripheral blood mononuclear cells were studied in all groups.
Gene_expression (production) of IFN-gamma in blood associated with pain
18) Confidence 0.77 Published 2004 Journal Pain Section Abstract Doc Link 15327822 Disease Relevance 0.53 Pain Relevance 0.68
The spontaneous behaviours, pain-related behaviours and interferon-gamma (IFN-gamma) production by peripheral blood mononuclear cells were studied in all groups.
Gene_expression (production) of interferon-gamma in blood associated with pain
19) Confidence 0.77 Published 2004 Journal Pain Section Abstract Doc Link 15327822 Disease Relevance 0.54 Pain Relevance 0.68
Indeed, formalin injection per se decreased IFN-gamma production; estradiol had no effect on sham-injected animals but strongly reduce the decrease of IFN-gamma production in formalin-injected animals.
Gene_expression (production) of IFN-gamma
20) Confidence 0.77 Published 2004 Journal Pain Section Abstract Doc Link 15327822 Disease Relevance 0.28 Pain Relevance 0.56

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