INT10360

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Context Info
Confidence 0.68
First Reported 1990
Last Reported 2009
Negated 1
Speculated 1
Reported most in Abstract
Documents 33
Total Number 34
Disease Relevance 21.73
Pain Relevance 15.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ifng) extracellular region (Ifng)
Anatomy Link Frequency
macrophages 2
PGE2 2
neurons 2
lymph node 1
cerebrospinal fluid 1
Ifng (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 52 100.00 Very High Very High Very High
Inflammation 31 100.00 Very High Very High Very High
Arthritis 11 100.00 Very High Very High Very High
antidepressant 28 99.80 Very High Very High Very High
Central nervous system 2 99.68 Very High Very High Very High
antagonist 2 99.66 Very High Very High Very High
Multiple sclerosis 2 98.68 Very High Very High Very High
Morphine 8 98.64 Very High Very High Very High
aspirin 14 98.50 Very High Very High Very High
Paracetamol 9 98.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 27 100.00 Very High Very High Very High
Cancer 12 100.00 Very High Very High Very High
Necrosis 11 100.00 Very High Very High Very High
Arthritis 11 100.00 Very High Very High Very High
Appetite Loss 2 99.44 Very High Very High Very High
Immunization 13 99.36 Very High Very High Very High
Leukemia 3 99.08 Very High Very High Very High
Disease 12 98.80 Very High Very High Very High
Demyelinating Disease 12 98.68 Very High Very High Very High
Viral Meningitis 4 98.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, systemically increased gamma-IFN serum levels were not specific for a neuritogenic T-cell response.
Positive_regulation (increased) of gamma-IFN in T-cell
1) Confidence 0.68 Published 1992 Journal Brain Section Abstract Doc Link 1486454 Disease Relevance 0.91 Pain Relevance 0.20
Prolonged increases in the level of the pro-inflammatory cytokine interferon-gamma occur in the CNS during some disease states associated with persistent pain.
Positive_regulation (increases) of interferon-gamma associated with pain, inflammation, lasting pain, disease and cytokine
2) Confidence 0.60 Published 2005 Journal Neuroscience Section Abstract Doc Link 16125859 Disease Relevance 0.47 Pain Relevance 0.55
High levels of tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) mRNAs were also detected, and both these cytokines can be harmful to several types of CNS cells, including neurons.
Positive_regulation (levels) of interferon-gamma in neurons associated with necrosis, cancer and cytokine
3) Confidence 0.52 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10884312 Disease Relevance 0.74 Pain Relevance 0.13
These findings show that the prolonged presence of increased levels of IFN-gamma in the central nervous system may contribute to the generation of central sensitization and persistent pain by reducing inhibitory tone in the dorsal horn.
Positive_regulation (increased) of IFN-gamma in central nervous system associated with pain, central sensitization, lasting pain, dorsal horn and central nervous system
4) Confidence 0.47 Published 2007 Journal Pain Section Abstract Doc Link 17407800 Disease Relevance 0.27 Pain Relevance 0.72
Inhibitory effects of interferon-gamma on activation of rat pancreatic stellate cells are mediated by STAT1 and involve down-regulation of CTGF expression.
Positive_regulation (effects) of interferon-gamma in stellate cells
5) Confidence 0.46 Published 2007 Journal Cell. Signal. Section Title Doc Link 17116388 Disease Relevance 0.41 Pain Relevance 0.18
It attenuated the expressions of ethanol-induced pro-inflammatory cytokines, including interleukin (IL)-1beta and interferon-gamma, a weak activation of IL-10, the inhibition of the alcohol-induced overexpression of intercellular adhesion molecule-1, and the considerable induction of heat shock protein-72 expression in gastric mucosal homogenates.
Positive_regulation (activation) of interferon-gamma
6) Confidence 0.45 Published 2008 Journal J. Gastroenterol. Hepatol. Section Body Doc Link 18444990 Disease Relevance 0.07 Pain Relevance 0
Analysis of serum cytokine profile using enzymelinked immunosorbent assay (ELISA) showed a drastic increase in interleukin (IL)-1beta, IL-6, tumour necrosis factor-alpha (TNF)-alpha, interferon-gamma (IFN-gamma) and decrease in IL-10, Il-4 and prostaglandin E2 (PGE2) levels in NSAID (aspirin) treated rats.
Positive_regulation (increase) of interferon-gamma in PGE2 associated with aspirin, necrosis, cancer, cinod and cytokine
7) Confidence 0.45 Published 2008 Journal Int. Immunopharmacol. Section Abstract Doc Link 18773975 Disease Relevance 0.63 Pain Relevance 0.61
Analysis of serum cytokine profile using enzymelinked immunosorbent assay (ELISA) showed a drastic increase in interleukin (IL)-1beta, IL-6, tumour necrosis factor-alpha (TNF)-alpha, interferon-gamma (IFN-gamma) and decrease in IL-10, Il-4 and prostaglandin E2 (PGE2) levels in NSAID (aspirin) treated rats.
Positive_regulation (increase) of IFN-gamma in PGE2 associated with aspirin, necrosis, cancer, cinod and cytokine
8) Confidence 0.45 Published 2008 Journal Int. Immunopharmacol. Section Abstract Doc Link 18773975 Disease Relevance 0.63 Pain Relevance 0.61
High levels of tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) mRNAs were also detected, and both these cytokines can be harmful to several types of CNS cells, including neurons.
Positive_regulation (levels) of IFN-gamma in neurons associated with necrosis, cancer and cytokine
9) Confidence 0.45 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10884312 Disease Relevance 0.74 Pain Relevance 0.13
Quantitative PCR also showed increased IFN-gamma mRNA levels in the inflamed tissue of morphine-treated rats.
Positive_regulation (increased) of IFN-gamma mRNA associated with morphine
10) Confidence 0.44 Published 1999 Journal Clin. Immunol. Section Abstract Doc Link 10527694 Disease Relevance 0.80 Pain Relevance 0.77
At concentrations < 10(-5) M most tested drugs significantly enhanced IFN-gamma induced MHC class II expression.
Positive_regulation (enhanced) of IFN-gamma
11) Confidence 0.43 Published 1994 Journal Immunopharmacology Section Abstract Doc Link 8071062 Disease Relevance 0.46 Pain Relevance 0.84
The modulatory effect of antidepressant drugs on IFN-gamma induced MHC class I and II expression may contribute to their influence on demyelinating autoimmune diseases, and may have implications for their clinical use.
Positive_regulation (induced) of IFN-gamma associated with antidepressant, autoimmune disease and demyelinating disease
12) Confidence 0.43 Published 1994 Journal Immunopharmacology Section Abstract Doc Link 8071062 Disease Relevance 0.59 Pain Relevance 0.64
At concentrations < 10(-5) M most tested drugs significantly enhanced IFN-gamma induced MHC class II expression.
Positive_regulation (induced) of IFN-gamma
13) Confidence 0.43 Published 1994 Journal Immunopharmacology Section Abstract Doc Link 8071062 Disease Relevance 0.46 Pain Relevance 0.84
This study examined the modulation of IFN-gamma induced MHC class I and II expression on normal Lewis rats and rats with EAN peritoneal macrophages cultured in the absence or presence of 10(-4)-10(-8) M of the 5-HT reuptake inhibiting antidepressants zimeldine, and its metabolites norzimeldine and cpp200 oxalate as well as the antidepressants clomipramine and imipramine, in addition amitriptyline, nortriptyline and maprotiline in EAN rats.
Spec (examined) Positive_regulation (induced) of IFN-gamma in peritoneal macrophages associated with nortriptyline, antidepressant, endep and neuritis
14) Confidence 0.43 Published 1994 Journal Immunopharmacology Section Abstract Doc Link 8071062 Disease Relevance 0.33 Pain Relevance 0.62
The action of clomipramine and imipramine on induced IFN-gamma and anti-myelin antibodies suggests that the mechanism for the suppressive effect of those substances on EAN symptoms may be due to an action on myelin T and B cell autoreactivity.
Positive_regulation (induced) of IFN-gamma in B cell associated with neuritis
15) Confidence 0.37 Published 1998 Journal J. Autoimmun. Section Abstract Doc Link 9776709 Disease Relevance 0.97 Pain Relevance 0.78
Significant levels of mRNA for IFNgamma could be found at days 4 and 7, whereas IL12p40-mRNA showed a biphasic induction.
Positive_regulation (induction) of IFNgamma
16) Confidence 0.36 Published 1998 Journal J. Neurosci. Res. Section Abstract Doc Link 9514202 Disease Relevance 0.55 Pain Relevance 0.69
The increases in IL-1beta, interferon-gamma, and tumor necrosis factor-alpha in the control rats were 1.5-8 times greater than those in the smoke-exposed rats.
Positive_regulation (increases) of interferon-gamma
17) Confidence 0.29 Published 1999 Journal Anesthesiology Section Body Doc Link 10598627 Disease Relevance 0 Pain Relevance 0
The modulatory effect of antidepressant drugs on IFN-gamma induced MHC class I and II expression may contribute to their influence on demyelinating autoimmune diseases, and may have implications for their clinical use.
Positive_regulation (induced) of IFN-gamma associated with antidepressant, autoimmune disease and demyelinating disease
18) Confidence 0.28 Published 1997 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 10975734 Disease Relevance 0.90 Pain Relevance 0.81
In addition, interferon-gamma and nitric oxide levels in the gastric mucosa of AA rats were increased by the oral administration of indomethacin.
Positive_regulation (increased) of interferon-gamma associated with arthritis
19) Confidence 0.25 Published 2009 Journal Toxicology Section Abstract Doc Link 18996434 Disease Relevance 0.85 Pain Relevance 0.65
Restricted areas showed elevations in messenger RNA expression of interleukin-1 receptor antagonist, interleukin-6, inducible nitric oxide synthase, interferon-gamma, and inducible cyclooxygenase.
Positive_regulation (inducible) of interferon-gamma associated with antagonist
20) Confidence 0.18 Published 2000 Journal Neuroscience Section Abstract Doc Link 10683422 Disease Relevance 0.55 Pain Relevance 0.45

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