INT103603

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Context Info
Confidence 0.51
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 12.29
Pain Relevance 2.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp2) extracellular space (Mmp2) extracellular region (Mmp2)
proteinaceous extracellular matrix (Mmp2) plasma membrane (Mmp2) nucleus (Mmp2)
Anatomy Link Frequency
lung 6
alveolar macrophages 2
fibroblast 2
Mmp2 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 80 100.00 Very High Very High Very High
cINOD 26 99.96 Very High Very High Very High
Inflammation 152 93.64 High High
agonist 12 76.88 Quite High
Potency 9 74.88 Quite High
aspirin 1 56.88 Quite High
cva 1 48.88 Quite Low
antagonist 31 38.72 Quite Low
Angina 2 36.76 Quite Low
palliative 3 13.60 Low Low
Disease Link Frequency Relevance Heat
Repression 1 99.80 Very High Very High Very High
INFLAMMATION 174 99.68 Very High Very High Very High
Cancer 903 99.64 Very High Very High Very High
Lung Cancer 2 98.36 Very High Very High Very High
Metastasis 313 98.04 Very High Very High Very High
Apoptosis 83 96.84 Very High Very High Very High
Osteogenic Sarcomas 68 94.72 High High
Colon Cancer 13 88.32 High High
Breast Cancer 62 85.92 High High
Chronic Hepatitis 1 80.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that the TGZ-induced inhibition of MMP-2 expression within the tumor may prevent the local invasion at the primary site, thus resulting in the suppression of the development of metastasis in the lung.
Negative_regulation (inhibition) of Gene_expression (expression) of MMP-2 in lung associated with cancer and metastasis
1) Confidence 0.51 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2838820 Disease Relevance 1.23 Pain Relevance 0
TM treatment of OSCC-3 and EC-Bcl-2 significantly inhibited MMP-2 production.
Negative_regulation (inhibited) of Gene_expression (production) of MMP-2
2) Confidence 0.38 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2922193 Disease Relevance 0.88 Pain Relevance 0.04
Taken together, our in vivo findings suggest that administration of TGZ not only decreases the expression of MMP-2 and invasiveness, but also decreases the expression of VEGF and local vessel formation, thus preventing both the growth of primary osteosarcoma and the development of metastasis in the lung.
Negative_regulation (decreases) of Gene_expression (expression) of MMP-2 in lung associated with osteogenic sarcomas and metastasis
3) Confidence 0.38 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2838820 Disease Relevance 1.16 Pain Relevance 0.04
Treatment of tumor-bearing mice with TGZ decreases the expression and activity of MMP-2 within the tumor, and inhibits primary tumor growth and pulmonary metastasis development.
Negative_regulation (decreases) of Gene_expression (expression) of MMP-2 associated with cancer and metastasis
4) Confidence 0.38 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2838820 Disease Relevance 1.19 Pain Relevance 0.03
The results of immunohistochemistry (Figure 6A) and gelatin zymography (Figure 6B) showed that the tumors of the TGZ group exhibited lower expression and activity of MMP-2 compared with the control group.
Negative_regulation (exhibited) of Gene_expression (expression) of MMP-2 associated with cancer
5) Confidence 0.37 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2838820 Disease Relevance 1.27 Pain Relevance 0
This TM-mediated decrease in MMP-2 production could be due to its inhibitory effect on FAK as it has been shown that blocking of FAK activity by either dominant negative mutants or antisence treatment significantly decreases MMP expression [44,45].
Negative_regulation (decrease) of Gene_expression (production) of MMP-2
6) Confidence 0.34 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2922193 Disease Relevance 0.88 Pain Relevance 0.04
Interestingly, MMP2 expression was only very low (not shown).
Negative_regulation (low) of Gene_expression (expression) of MMP2
7) Confidence 0.31 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2933604 Disease Relevance 0.44 Pain Relevance 0.19
TM treatment of EC-Bcl-2 and OSCC-3 significantly inhibited MMP2 production (Fig. 5C-D).


Negative_regulation (inhibited) of Gene_expression (production) of MMP2
8) Confidence 0.28 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2922193 Disease Relevance 0.90 Pain Relevance 0
Compared to a scrambled control siRNA, both oligonucleotides mediated efficient and specific knockdown of their respective target mRNAs without reducing expression of closely related insulin-like growth factor (IGF) 1 receptor and MMP-2 mRNA (Figure 6F).
Negative_regulation (reducing) of Gene_expression (expression) of MMP-2 mRNA associated with metalloproteinase
9) Confidence 0.16 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.29 Pain Relevance 0.40
Expression of ERK1/2 was also reduced by 27 ± 7.7% and 31 ± 8.7% respectively. mRNA expression of matrix metalloproteinase-2 (MMP2) was reduced by 35 ± 6.8% and zymography showed MMP2 proteolytic activity was reduced by 32 ± 8.5%.
Negative_regulation (reduced) of Gene_expression (expression) of matrix metalloproteinase-2 associated with metalloproteinase
10) Confidence 0.09 Published 2009 Journal Lipids Health Dis Section Abstract Doc Link PMC2661078 Disease Relevance 0.61 Pain Relevance 0.05
Expression of ERK1/2 was also reduced by 27 ± 7.7% and 31 ± 8.7% respectively. mRNA expression of matrix metalloproteinase-2 (MMP2) was reduced by 35 ± 6.8% and zymography showed MMP2 proteolytic activity was reduced by 32 ± 8.5%.
Negative_regulation (reduced) of Gene_expression (expression) of matrix metalloproteinase-2 associated with metalloproteinase
11) Confidence 0.09 Published 2009 Journal Lipids Health Dis Section Abstract Doc Link PMC2661078 Disease Relevance 0.66 Pain Relevance 0.05
Antioxidants N-acetylcysteine and pyrrolidine dithiocarbamate, and the NADPH oxidase inhibitors diphenylene iodonium chloride and apocynin decreased the production of MMP-2 and -9 in alveolar macrophages from surfactant protein D-deficient mice (Yoshida et al 2001).
Negative_regulation (decreased) of Gene_expression (production) of MMP-2 in alveolar macrophages associated with metalloproteinase
12) Confidence 0.07 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.58 Pain Relevance 0.37
Interleukin-10 induced ATF-3 transcriptional suppression of matrix metalloproteinase-2 gene expression in human prostate CPTX-1532 cells [53].
Negative_regulation (suppression) of Gene_expression (expression) of matrix metalloproteinase-2 gene associated with metalloproteinase
13) Confidence 0.04 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 1.08 Pain Relevance 0.16
Our previous data showed that nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit matrix metalloproteinase-2 (MMP-2) expression via repression of gene transcription in lung cancer cells.
Negative_regulation (inhibit) of Gene_expression (expression) of matrix metalloproteinase-2 in lung associated with lung cancer, inflammation, repression, metalloproteinase and cinod
14) Confidence 0.04 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12087091 Disease Relevance 0.37 Pain Relevance 0.60
Recently, Ryu et al. (2009) demonstrated that methanol extracts of alga Corallina pilulifera possessed a high phenolic content, which reduced the expression of UV-induced MMP-2 and -9, in human dermal fibroblast in a dose dependent manner, thereby attaining the capability of inhibiting free radicals [30].
Negative_regulation (reduced) of Gene_expression (expression) of MMP-2 in fibroblast
15) Confidence 0.01 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2993000 Disease Relevance 0.29 Pain Relevance 0
We have previously reported that a NSAID NS398 repressed the expression of matrix metalloproteinase-2 (MMP-2) via inhibition of the extracellular signal-regulated kinase (ERK) signaling pathway.
Negative_regulation (repressed) of Gene_expression (expression) of metalloproteinase-2 associated with metalloproteinase and cinod
16) Confidence 0.00 Published 2008 Journal Cell. Signal. Section Abstract Doc Link 18374541 Disease Relevance 0.46 Pain Relevance 0.50

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