INT103607

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Context Info
Confidence 0.42
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.26
Pain Relevance 2.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Sp1) nucleus (Sp1) intracellular (Sp1)
DNA binding (Sp1) transcription factor binding (Sp1) cytoplasm (Sp1)
Anatomy Link Frequency
motor neurons 1
Sp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 34 99.62 Very High Very High Very High
mu opioid receptor 8 93.20 High High
metalloproteinase 7 83.84 Quite High
opioid receptor 1 75.00 Quite High
Spinal cord 31 57.04 Quite High
Morphine 1 55.96 Quite High
Inflammation 4 50.00 Quite Low
chemokine 2 23.04 Low Low
ischemia 1 16.24 Low Low
aspirin 1 10.00 Low Low
Disease Link Frequency Relevance Heat
Lung Cancer 5 86.76 High High
Cancer 69 85.28 High High
Repression 6 85.28 High High
Necrosis 1 84.80 Quite High
INFLAMMATION 16 81.92 Quite High
Injury 67 80.40 Quite High
Embryonal Carcinoma 1 62.16 Quite High
Targeted Disruption 3 45.72 Quite Low
Apoptosis 12 24.20 Low Low
Cv Unclassified Under Development 1 16.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly the non-specific general activator proteins SP1 and E2F1 have been shown to interact to promote transcription [45] and in motor neurons they can drive the transcription of the motor neuron specific transcription factor HB9 [46].
SP1 Binding (interact) of in motor neurons
1) Confidence 0.42 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2900267 Disease Relevance 0.08 Pain Relevance 0.03
KDR gene expression that involve the enhancement of Sp1-DNA binding in absence
Sp1 Binding (binding) of
2) Confidence 0.35 Published 2008 Journal PPAR Research Section Body Doc Link PMC2366048 Disease Relevance 0.17 Pain Relevance 0
Exposure to NSAIDs inhibits Sp1 binding to its promoter and abrogates CSE expression in HEK-293 cells transfected with a vector containing the core CSE promoter.
Sp1 Binding (binding) of
3) Confidence 0.29 Published 2005 Journal Gastroenterology Section Body Doc Link 16230075 Disease Relevance 0 Pain Relevance 0
NSAID treatment reduces Sp1 DNA binding activity and phosphorylation and attenuates MMP-2 expression.
Sp1 Binding (binding) of associated with cinod
4) Confidence 0.10 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12087091 Disease Relevance 0.31 Pain Relevance 0.86
Electrophoretic mobility shift assays show that Sp1 and Sp3 proteins constitutively bind to this consensus sequence and overexpression of Sp1 may enhance MMP-2 expression.
Sp1 Binding (bind) of
5) Confidence 0.10 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12087091 Disease Relevance 0.33 Pain Relevance 0.80
In vitro DNA CpG-methylation of the promoter partially blocked binding of the Sp1 factor but induced MeCP2 binding.
Sp1 factor Binding (binding) of
6) Confidence 0.10 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20385708 Disease Relevance 0.06 Pain Relevance 0.36
NSAID treatment reduces Sp1 DNA binding activity and phosphorylation and attenuates MMP-2 expression.
Sp1 Binding (activity) of associated with cinod
7) Confidence 0.07 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12087091 Disease Relevance 0.31 Pain Relevance 0.87

General Comments

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