INT103624

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Context Info
Confidence 0.56
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.58
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grin2a) plasma membrane (Grin2a) locomotion (Grin2a)
Anatomy Link Frequency
brain 2
peripheral nerve 2
Grin2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 56 98.92 Very High Very High Very High
Dorsal horn 5 98.88 Very High Very High Very High
nMDA receptor 88 97.96 Very High Very High Very High
Glutamate 27 94.72 High High
Spontaneous pain 1 93.52 High High
Inflammation 10 89.16 High High
Spinal cord 3 79.08 Quite High
Pain 9 77.36 Quite High
gABA 1 72.56 Quite High
Pyramidal cell 4 55.68 Quite High
Disease Link Frequency Relevance Heat
Brain Hemorrhage 38 99.52 Very High Very High Very High
Pain 5 92.56 High High
Spinal Injuries 2 90.40 High High
Injury 15 89.32 High High
Arthritis 2 89.16 High High
Frailty 2 79.36 Quite High
INFLAMMATION 8 75.00 Quite High
Cv Unclassified Under Development 16 54.40 Quite High
Infarction 5 50.00 Quite Low
Death 9 37.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also report a reduced expression of NR2A following peripheral nerve lesion.
Negative_regulation (reduced) of Gene_expression (expression) of NR2A in peripheral nerve
1) Confidence 0.56 Published 2002 Journal Neuroscience Section Abstract Doc Link 12088745 Disease Relevance 0.16 Pain Relevance 0.68
CONCLUSION: The protective effects of ketamine-midazolam anesthesia on ischemic brain injury may related to decreasing NR2A and NR2B expression.


Negative_regulation (decreasing) of Gene_expression (expression) of NR2A in brain
2) Confidence 0.39 Published 2006 Journal Chin. Med. J. Section Body Doc Link 16996010 Disease Relevance 0 Pain Relevance 0
However, the expression of NR2A and NR2B in the penumbra was reversed 24 h after focal cerebral ischemia (NR2A: 40±7% of sham-operated controls; NR2B: 120±16% of sham-operated controls, respectively, n=4, *P<0.05) (Fig. 4A, B).


Negative_regulation (reversed) of Gene_expression (expression) of NR2A associated with brain hemorrhage and ischemia
3) Confidence 0.29 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC3015038 Disease Relevance 0.86 Pain Relevance 0.52
Using antibodies that selectively label NR1, NR2A, or NR2B subunits, we found that the protein levels of NR1, NR2A, and NR2B subunits were significantly decreased by 10 µM UCB treatment for 24 or 48 h (Figure 4).
Negative_regulation (decreased) of Gene_expression (levels) of NR2A
4) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690688 Disease Relevance 0 Pain Relevance 0.37
Real-time PCR was used to evaluate gene expression of NK-1R, NR-1, and NR-2A.
Negative_regulation (evaluate) of Gene_expression (expression) of NR-2A
5) Confidence 0.04 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15922485 Disease Relevance 0.55 Pain Relevance 0.33

General Comments

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