INT103651

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Context Info
Confidence 0.78
First Reported 2002
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.23
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL1B, IL8) extracellular space (IL1B, IL8) extracellular region (IL1B, IL8)
cytosol (IL1B) aging (IL1B) intracellular (IL8)
Anatomy Link Frequency
TMJ 4
joint 2
IL1B (Homo sapiens)
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 79 100.00 Very High Very High Very High
rheumatoid arthritis 121 90.40 High High
antagonist 11 85.96 High High
Inflammation 42 75.00 Quite High
Catecholamine 16 69.12 Quite High
Infliximab 5 58.60 Quite High
Arthritis 10 56.52 Quite High
Etanercept 1 53.52 Quite High
dexamethasone 4 52.56 Quite High
Snapping jaw 8 50.00 Quite Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 121 90.40 High High
Atherosclerosis 18 80.80 Quite High
INFLAMMATION 39 75.00 Quite High
Stress 13 75.00 Quite High
Increased Venous Pressure Under Development 4 72.60 Quite High
Temporomandibular Joint Syndrome 8 65.28 Quite High
Arthritis 10 56.52 Quite High
Disease 16 53.80 Quite High
Apoptosis 5 50.00 Quite Low
Pain 2 44.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, IL-1beta enhanced IL-8 production in HTS cells in a time- and dose-dependent manner and stimulated IL-8 gene expression.
IL-1beta Positive_regulation (stimulated) of Gene_expression (expression) of IL-8
1) Confidence 0.78 Published 2002 Journal J. Oral Maxillofac. Surg. Section Body Doc Link 12089685 Disease Relevance 0.07 Pain Relevance 0
Furthermore, IL-1beta enhanced IL-8 production in HTS cells in a time- and dose-dependent manner and stimulated IL-8 gene expression.
IL-1beta Positive_regulation (enhanced) of Gene_expression (production) of IL-8
2) Confidence 0.78 Published 2002 Journal J. Oral Maxillofac. Surg. Section Body Doc Link 12089685 Disease Relevance 0.07 Pain Relevance 0
In addition, we found that IL-1beta stimulated IL-8 production through an increase in IL-8 gene expression in HTS cells, which may be associated with the increase of infiltrating inflammatory cells seen in the synovial membrane of TMJ disorders.


IL-1beta Positive_regulation (stimulated) of Gene_expression (production) of IL-8 in TMJ
3) Confidence 0.78 Published 2002 Journal J. Oral Maxillofac. Surg. Section Body Doc Link 12089685 Disease Relevance 0.05 Pain Relevance 0
In addition, we found that IL-1beta stimulated IL-8 production through an increase in IL-8 gene expression in HTS cells, which may be associated with the increase of infiltrating inflammatory cells seen in the synovial membrane of TMJ disorders.


IL-1beta Positive_regulation (increase) of Gene_expression (expression) of IL-8 in TMJ
4) Confidence 0.52 Published 2002 Journal J. Oral Maxillofac. Surg. Section Body Doc Link 12089685 Disease Relevance 0.05 Pain Relevance 0
IL-1 and TNF stimulate the production of degradative proteases and cytokines such as IL-1, IL-6, IL-8 and MCP-1 by joint tissue cells, contributing to joint destruction.
IL-1 Positive_regulation (stimulate) of Gene_expression (production) of IL-8 in joint associated with cytokine
5) Confidence 0.05 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400438 Disease Relevance 0.62 Pain Relevance 0.58
However, IL-6, IL-8, and IL-13 production induced by IL-1?
IL-1 Positive_regulation (induced) of Gene_expression (production) of IL-8
6) Confidence 0.01 Published 2004 Journal BMC Immunol Section Abstract Doc Link PMC521685 Disease Relevance 0.37 Pain Relevance 0.41

General Comments

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