INT103659

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 2002
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 10
Total Number 22
Disease Relevance 7.20
Pain Relevance 7.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Muc4) extracellular region (Muc4) cell adhesion (Muc4)
endoplasmic reticulum (Muc4) plasma membrane (Muc4) protein complex (Muc4)
Anatomy Link Frequency
testis 4
pancreas 3
diencephalon 3
liver 2
brain 2
Muc4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
IPN 11 98.96 Very High Very High Very High
Chronic pancreatitis 24 98.44 Very High Very High Very High
Morphine 583 98.08 Very High Very High Very High
Lasting pain 11 97.92 Very High Very High Very High
mu opioid receptor 2 92.40 High High
Opioid 69 88.56 High High
Pain 209 88.00 High High
opioid receptor 23 80.24 Quite High
Hippocampus 22 73.64 Quite High
Analgesic 22 71.28 Quite High
Disease Link Frequency Relevance Heat
Adenocarcinoma 48 99.92 Very High Very High Very High
Inflammatory Pain 11 98.96 Very High Very High Very High
Pancreatitis 30 98.44 Very High Very High Very High
Metaplasia 5 98.32 Very High Very High Very High
Pain 220 97.92 Very High Very High Very High
Cancer 36 97.80 Very High Very High Very High
Carcinoma 7 95.96 Very High Very High Very High
Adenoma 7 95.56 Very High Very High Very High
Malignant Neoplastic Disease 6 93.64 High High
Adhesions 3 88.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We documented the pattern of expression of MUC4 in PanINs by studying a series of 71 PanIN lesions immunohistochemically using a new monoclonal antibody to MUC4.
Gene_expression (expression) of MUC4
1) Confidence 0.78 Published 2002 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 12090430 Disease Relevance 0.73 Pain Relevance 0.07
MUC4 expression increases progressively in pancreatic intraepithelial neoplasia.
Gene_expression (expression) of MUC4 associated with cancer
2) Confidence 0.78 Published 2002 Journal Am. J. Clin. Pathol. Section Title Doc Link 12090430 Disease Relevance 0.70 Pain Relevance 0.06
MUC4 expression is not detectable at the RNA level in normal pancreas but is detectable at high levels in invasive pancreatic adenocarcinoma.
Gene_expression (expression) of MUC4 in pancreas associated with adenocarcinoma
3) Confidence 0.78 Published 2002 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 12090430 Disease Relevance 0.67 Pain Relevance 0.05
Our data help establish the patterns of MUC4 expression in neoplastic precursors in the pancreas and add further support to the progression model for pancreatic adenocarcinoma.
Gene_expression (expression) of MUC4 in pancreas associated with adenocarcinoma
4) Confidence 0.78 Published 2002 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 12090430 Disease Relevance 0.78 Pain Relevance 0.09
In addition to its involvement in the covering of luminal epithelia, recent studies suggest that the overexpression of the MUC4 rat homologue sialomucin complex (SMC) disrupts integrin-mediated cell-matrix and cell-cell interaction and inhibits immune recognition [33].
Gene_expression (overexpression) of sialomucin complex in covering
5) Confidence 0.75 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149423 Disease Relevance 0.74 Pain Relevance 0.06
Muc4 expression was also examined by immunohistochemistry.
Spec (examined) Gene_expression (expression) of Muc4
6) Confidence 0.71 Published 2006 Journal Pancreas Section Body Doc Link 17079941 Disease Relevance 0 Pain Relevance 0
No changes in the expression of Muc1 and Muc4 mucins were observed.
Gene_expression (expression) of Muc4
7) Confidence 0.71 Published 2006 Journal Pancreas Section Body Doc Link 17079941 Disease Relevance 0 Pain Relevance 0
In comparison, MUC4 and mesothelin were expressed more frequently in pancreatic adenocarcinoma on tissue sections.
Gene_expression (expressed) of MUC4 associated with adenocarcinoma
8) Confidence 0.71 Published 2006 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 17019794 Disease Relevance 0.61 Pain Relevance 0.08
In addition, afew nonneoplastic lesions labeled with the MUC4 antibody, including reactive ducts in chronic pancreatitis, atrophic ducts filled with inspissated secretions, and ducts showing squamous metaplasia.
Gene_expression (labeled) of MUC4 in ducts associated with metaplasia and chronic pancreatitis
9) Confidence 0.67 Published 2002 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 12090430 Disease Relevance 0.74 Pain Relevance 0.10
The expression profiles of trypsinogen, pancreas-specific trypsin inhibitor, cholecystokinin A receptor, cystic fibrosis transmembrane conductance regulator (CFTR), carbonic anhydrase, and Muc1 and Muc4 mucins transcripts were analyzed by RNA slot blot analysis.
Spec (analyzed) Gene_expression (expression) of Muc4 in pancreas
10) Confidence 0.62 Published 2006 Journal Pancreas Section Body Doc Link 17079941 Disease Relevance 0 Pain Relevance 0
Our data indicate that 5aR-1 expression was much higher in the diencephalon than in the liver (used as reference, i.e. 1) while its expression in the testis was only half that in the liver.
Gene_expression (expression) of testis in diencephalon
11) Confidence 0.07 Published 2010 Journal Mol Pain Section Body Doc Link PMC2978140 Disease Relevance 0.06 Pain Relevance 0.39
In our adult male rats, AROM was much more highly expressed in liver than in the diencephalon and testis; nevertheless, its physiological role is not very clear since liver is generally considered a non-steroidogenic tissue [35,36].
Gene_expression (expressed) of testis in testis
12) Confidence 0.06 Published 2010 Journal Mol Pain Section Body Doc Link PMC2978140 Disease Relevance 0.23 Pain Relevance 0.39
The high AROM mRNA expression observed in the diencephalon and testis suggests an increase in enzymatic activity resulting in increased metabolism of testosterone to estradiol (E2).
Gene_expression (expression) of testis in diencephalon
13) Confidence 0.06 Published 2010 Journal Mol Pain Section Body Doc Link PMC2978140 Disease Relevance 0.12 Pain Relevance 0.31
The main result of the present experiment is that the expression of 5-alpha reductase type 1 (5aR-1) and p450-aromatase (AROM) in the male rat brain, liver and testis was strongly affected by inflammatory pain and morphine.
Gene_expression (expression) of testis in testis associated with ipn and morphine
14) Confidence 0.06 Published 2010 Journal Mol Pain Section Body Doc Link PMC2978140 Disease Relevance 0.31 Pain Relevance 0.73
The purpose of this study on male rats was to determine the effects of a single injection of morphine (5 mg/Kg) on persistent pain (formalin test) and the single or combined effects on p450-aromatase and 5-alpha reductase type 1 mRNA expression in the brain, liver and testis.
Gene_expression (expression) of testis in testis associated with pain, lasting pain and morphine
15) Confidence 0.06 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2978140 Disease Relevance 0.17 Pain Relevance 0.96
In our adult male rats, AROM was much more highly expressed in liver than in the diencephalon and testis; nevertheless, its physiological role is not very clear since liver is generally considered a non-steroidogenic tissue [35,36].
Gene_expression (expressed) of testis in diencephalon
16) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2978140 Disease Relevance 0.23 Pain Relevance 0.39
The high AROM mRNA expression observed in the diencephalon and testis suggests an increase in enzymatic activity resulting in increased metabolism of testosterone to estradiol (E2).
Gene_expression (expression) of testis in testis
17) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2978140 Disease Relevance 0.12 Pain Relevance 0.31
The purpose of this study on male rats was to determine the effects of a single injection of morphine (5 mg/Kg) on persistent pain (formalin test) and the single or combined effects on p450-aromatase and 5-alpha reductase type 1 mRNA expression in the brain, liver and testis.
Gene_expression (expression) of testis in brain associated with pain, lasting pain and morphine
18) Confidence 0.02 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2978140 Disease Relevance 0.17 Pain Relevance 0.96
The purpose of this study on male rats was to determine the effects of a single injection of morphine (5 mg/Kg) on persistent pain (formalin test) and the single or combined effects on p450-aromatase and 5-alpha reductase type 1 mRNA expression in the brain, liver and testis.
Gene_expression (expression) of testis in liver associated with pain, lasting pain and morphine
19) Confidence 0.02 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2978140 Disease Relevance 0.17 Pain Relevance 0.96
The main result of the present experiment is that the expression of 5-alpha reductase type 1 (5aR-1) and p450-aromatase (AROM) in the male rat brain, liver and testis was strongly affected by inflammatory pain and morphine.
Gene_expression (expression) of testis in liver associated with ipn and morphine
20) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2978140 Disease Relevance 0.31 Pain Relevance 0.73

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox