INT103673

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Context Info
Confidence 0.60
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 4.94
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpinf1) extracellular region (Serpinf1)
Anatomy Link Frequency
retina 6
retinal ganglion cell 6
optic nerve 4
blood 2
Serpinf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 199 91.60 High High
ischemia 33 75.60 Quite High
cytokine 26 55.76 Quite High
Angina 1 50.00 Quite Low
Inflammatory marker 11 7.44 Low Low
ketamine 24 5.00 Very Low Very Low Very Low
Multiple sclerosis 22 5.00 Very Low Very Low Very Low
Glutamate 22 5.00 Very Low Very Low Very Low
anesthesia 13 5.00 Very Low Very Low Very Low
glial activation 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 99 99.24 Very High Very High Very High
Wound Healing 1 98.52 Very High Very High Very High
Glaucoma 408 95.40 Very High Very High Very High
INFLAMMATION 224 91.60 High High
Coronary Artery Disease 1 86.80 High High
Aging 11 82.56 Quite High
Injury 48 78.68 Quite High
Death 100 77.76 Quite High
Ocular Hypertension 88 77.40 Quite High
Burns 3 76.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ocular PEDF gene transfection in DBA/2J mice leads to increased intraocular PEDF expression, improved retinal ganglion cell survival, and better vision
Positive_regulation (increased) of Gene_expression (expression) of PEDF in retinal ganglion cell associated with ganglion cysts
1) Confidence 0.60 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.32 Pain Relevance 0
The long-term effect of PEDF gene transfer on RGC survival was also examined.
Positive_regulation (transfer) of Gene_expression (transfer) of PEDF gene
2) Confidence 0.49 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.07 Pain Relevance 0
Ocular PEDF gene transfection in DBA/2J mice leads to increased intraocular PEDF expression, improved retinal ganglion cell survival, and better vision
Positive_regulation (leads) of Gene_expression (transfection) of PEDF gene in retinal ganglion cell associated with ganglion cysts
3) Confidence 0.49 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.33 Pain Relevance 0
Ocular PEDF gene transfection in DBA/2J mice leads to increased intraocular PEDF expression, improved retinal ganglion cell survival, and better vision
Positive_regulation (increased) of Gene_expression (expression) of PEDF in retinal ganglion cell associated with ganglion cysts
4) Confidence 0.43 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.32 Pain Relevance 0
We demonstrate that endogenous PEDF expression in retina and optic nerve of DBA/2J mice declines with age, while PEDF transfection maintains RGC viability, inhibits TNF and IL-18 upregulation, and reduces GFAP expression.
Positive_regulation (transfection) of Gene_expression (transfection) of PEDF in optic nerve
5) Confidence 0.43 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 1.32 Pain Relevance 0.21
In contrast, AAV-PEDF transfected mice maintained near normal acuity throughout the study (Figure 7F).


Positive_regulation (transfected) of Gene_expression (transfected) of AAV-PEDF
6) Confidence 0.43 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.08 Pain Relevance 0.04
Transfection of AAV-PEDF resulted in a significant increase in PEDF protein level in retina from DBA/2J mice at 11 months of age (Figure 7C).
Positive_regulation (Transfection) of Gene_expression (Transfection) of AAV-PEDF in retina
7) Confidence 0.43 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.23 Pain Relevance 0
As an index of visual function, we compared optomotor acuity in AAV-GFP, AAV-PEDF, and control transfected mice from 1 to 11 months of age (until 9 months post transfection; Figure 7F).
Positive_regulation (transfected) of Gene_expression (transfected) of AAV-PEDF
8) Confidence 0.43 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.12 Pain Relevance 0.03
Ocular PEDF transfection reduces TNF and IL-18 expression in retina and optic nerve of DBA/2J mice
Positive_regulation (transfection) of Gene_expression (transfection) of PEDF in retina
9) Confidence 0.40 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.14 Pain Relevance 0.07
In the treated mice, the expression of PEDF decreased early and then increased progressively until day 14.
Positive_regulation (increased) of Gene_expression (expression) of PEDF
10) Confidence 0.39 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779062 Disease Relevance 0.37 Pain Relevance 0
We demonstrate that endogenous PEDF expression in retina and optic nerve of DBA/2J mice declines with age, while PEDF transfection maintains RGC viability, inhibits TNF and IL-18 upregulation, and reduces GFAP expression.
Positive_regulation (transfection) of in retina Gene_expression (transfection) of PEDF in optic nerve
11) Confidence 0.15 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 1.32 Pain Relevance 0.21
Ocular PEDF transfection reduces TNF and IL-18 expression in retina and optic nerve of DBA/2J mice
Positive_regulation (transfection) of in optic nerve Gene_expression (transfection) of PEDF in retina
12) Confidence 0.14 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.14 Pain Relevance 0.07
By flow cytometry and RNase protection assay, we found decreased surface expression but increased gene expression of the SDF-1alpha receptor CXCR-4 in peripheral blood mononuclear cells (PBMC) from patients with stable angina and patients with unstable angina.
Positive_regulation (increased) of Gene_expression (expression) of SDF in blood
13) Confidence 0.00 Published 2002 Journal Circulation Section Body Doc Link 12093767 Disease Relevance 0.17 Pain Relevance 0

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