INT103674

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Context Info
Confidence 0.69
First Reported 2002
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 32
Total Number 34
Disease Relevance 37.10
Pain Relevance 3.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (CXCR4) plasma membrane (CXCR4) cytoplasm (CXCR4)
signal transducer activity (CXCR4)
Anatomy Link Frequency
stem cells 6
blood 2
stromal cell 2
Bone marrow 2
regulatory T cells 2
CXCR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 993 100.00 Very High Very High Very High
Inflammation 263 100.00 Very High Very High Very High
opioid receptor 1 100.00 Very High Very High Very High
Arthritis 18 98.00 Very High Very High Very High
rheumatoid arthritis 10 94.92 High High
antagonist 252 93.84 High High
cytokine 38 93.12 High High
methotrexate 3 81.88 Quite High
Hippocampus 6 80.40 Quite High
Opioid 2 78.64 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 301 100.00 Very High Very High Very High
Cancer 3275 99.98 Very High Very High Very High
Hypoxia 226 99.98 Very High Very High Very High
Colon Cancer 420 99.84 Very High Very High Very High
Muscular Dystrophy 70 99.84 Very High Very High Very High
Endometrial Cancer 15 99.84 Very High Very High Very High
Anaplastic Astrocytoma 23 99.64 Very High Very High Very High
Squamous Cell Carcinoma 10 99.44 Very High Very High Very High
Breast Cancer 550 99.36 Very High Very High Very High
Skin Cancer 100 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hypoxia increased CXCR4 mRNA expression in
Positive_regulation (increased) of Gene_expression (expression) of CXCR4 mRNA associated with hypoxia
1) Confidence 0.69 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.85 Pain Relevance 0
speculated that intratumoral hypoxia may lead to increased CXCR4 expression in
Spec (may) Positive_regulation (lead) of Gene_expression (expression) of CXCR4 associated with hypoxia
2) Confidence 0.69 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.86 Pain Relevance 0.03
had suggested that CXCR4 expression was necessary for the movement of tumor cells
Positive_regulation (necessary) of Gene_expression (expression) of CXCR4 associated with cancer
3) Confidence 0.69 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.16 Pain Relevance 0
speculated that intratumoral hypoxia may lead to increased CXCR4 expression in
Positive_regulation (increased) of Gene_expression (expression) of CXCR4 associated with hypoxia
4) Confidence 0.69 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.86 Pain Relevance 0.03
seven-transmembrane domain receptor (LESTR) due to its abundant expression in
Positive_regulation (due) of Gene_expression (expression) of LESTR
5) Confidence 0.67 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 0.42 Pain Relevance 0.21
By flow cytometry and RNase protection assay, we found decreased surface expression but increased gene expression of the SDF-1alpha receptor CXCR-4 in peripheral blood mononuclear cells (PBMC) from patients with stable angina and patients with unstable angina.
Positive_regulation (increased) of Gene_expression (expression) of CXCR-4 in blood
6) Confidence 0.67 Published 2002 Journal Circulation Section Body Doc Link 12093767 Disease Relevance 0.17 Pain Relevance 0
As far as endometrial cancer, studies on CXCR4 and CXCL12 expression revealed that CXCR4 is overexpressed in endometrial cancers as compared with normal tissues, whereas CXCL12 was overexpressed in normal mucosa.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of CXCR4 associated with endometrial cancer
7) Confidence 0.53 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.33 Pain Relevance 0
In the presence of SDF-1, stem cells are induced to produce MMP-9 and CXCR4.
Positive_regulation (induced) of Gene_expression (produce) of CXCR4 in stem cells
8) Confidence 0.50 Published 2008 Journal Cancer Cell Int Section Body Doc Link PMC2474582 Disease Relevance 0.14 Pain Relevance 0.09
contribution of CXCR4 to the metastatic process by transducing B16 murine
Positive_regulation (transducing) of Gene_expression (contribution) of CXCR4
9) Confidence 0.50 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.76 Pain Relevance 0.17
Concomitan high expression of CXCR4 and VEGF has been
Positive_regulation (high) of Gene_expression (expression) of CXCR4
10) Confidence 0.50 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.29 Pain Relevance 0.15
increased CXCR4 mRNA and cell-surface protein expression in several cell types,
Positive_regulation (increased) of Gene_expression (expression) of CXCR4 mRNA
11) Confidence 0.50 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.80 Pain Relevance 0.07
within tumors may also increase CXCR4 expression.

13.

Spec (may) Positive_regulation (increase) of Gene_expression (expression.) of CXCR4 associated with cancer
12) Confidence 0.50 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.06 Pain Relevance 0
Concomitan high expression of CXCR4 and VEGF has been
Positive_regulation (been) of Gene_expression (expression) of CXCR4
13) Confidence 0.50 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.30 Pain Relevance 0.15
CXCR4 expression is therefore a general
Positive_regulation (general) of Gene_expression (expression) of CXCR4
14) Confidence 0.50 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.92 Pain Relevance 0.03
seven-transmembrane domain receptor (LESTR) due to its abundant expression in
Positive_regulation (abundant) of Gene_expression (expression) of seven-transmembrane domain receptor
15) Confidence 0.50 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 0.43 Pain Relevance 0.21
CXCR4 expression in this context led to
Positive_regulation (led) of Gene_expression (expression) of CXCR4
16) Confidence 0.50 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.81 Pain Relevance 0.20
have shown that a unique population of CXCR4+ stem cells may be crucial for
Positive_regulation (population) of Gene_expression (stem cells) of CXCR4 in stem cells
17) Confidence 0.50 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 0.78 Pain Relevance 0.06
In comparison, EYFP-CXCR4 and ECFP-mu-opioid receptor-cotransfected cells displayed a much lower FRET signal.
Positive_regulation (cotransfected) of Gene_expression (cotransfected) of CXCR4 associated with opioid receptor
18) Confidence 0.50 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15014135 Disease Relevance 0.23 Pain Relevance 0.38
The levels of CD133+CXCR4+CD34- stem cells were significantly higher in DMD patients compared to healthy controls (mean±standard deviation: 17.38±1.38 vs. 11.0±1.70; P?
Positive_regulation (higher) of Gene_expression (levels) of CXCR4 in stem cells associated with muscular dystrophy
19) Confidence 0.49 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2377332 Disease Relevance 0.82 Pain Relevance 0
The chemokine ligand/receptor pair stromal cell-derived factor-1 (SDF-1, CXCL12)/CXCR4 is gaining increasing interest because of its involvement in the metastasis of several types of cancer and in certain inflammatory autoimmune disorders such as rheumatoid arthritis.
Positive_regulation (increasing) of Gene_expression (gaining) of CXCR4 in stromal cell associated with autoimmune disease, inflammation, cancer, rheumatoid arthritis and metastasis
20) Confidence 0.48 Published 2004 Journal Cytometry A Section Abstract Doc Link 15382150 Disease Relevance 0.72 Pain Relevance 0.30

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