INT103682

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Context Info
Confidence 0.17
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 3.17
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Krt7) cytoplasm (Krt7) structural molecule activity (Krt7)
nucleolus (Krt7) nucleus (Krt7) molecular_function (Krt7)
Anatomy Link Frequency
liver 1
stem 1
Krt7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
IPN 14 98.88 Very High Very High Very High
Bile 2 93.80 High High
imagery 5 41.56 Quite Low
anesthesia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cholangiocarcinoma 5 97.20 Very High Very High Very High
Cancer 209 96.76 Very High Very High Very High
Hepatocellular Cancer 245 96.62 Very High Very High Very High
Liver Cancer 65 85.76 High High
Metaplasia 3 74.80 Quite High
Carcinoma 6 72.68 Quite High
Carcinoma In Situ 1 69.08 Quite High
Cleidocranial Dysplasia 2 66.84 Quite High
Glioma 25 5.00 Very Low Very Low Very Low
Solid Tumor 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the differentially gene expressing profile of AFP and CK-7 in sorted SP cells and non-SP cells also confirmed by using western-blotting analysis.
Gene_expression (expressing) of CK-7
1) Confidence 0.17 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3022676 Disease Relevance 0.50 Pain Relevance 0
As shown in Figure, the relative expression of AFP and CK-7 were 0.84 ± 0.10, 0.53 ± 0.01 in SP from the fetal liver cells.
Gene_expression (expression) of CK-7 in liver
2) Confidence 0.17 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3022676 Disease Relevance 0.50 Pain Relevance 0
We next quantitatively compared the expression of AFP and CK-7 genes between sorted SP cells and non-SP cells.
Gene_expression (expression) of CK-7
3) Confidence 0.17 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3022676 Disease Relevance 0.48 Pain Relevance 0
To compare the expression of AFP and CK-7 between SP and non-SP and validate the differential expression of miRNAs in SP fractions, we applied real-time RT-PCR analysis to sorted cells.
Gene_expression (expression) of CK-7
4) Confidence 0.15 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3022676 Disease Relevance 0.07 Pain Relevance 0
To identify the unique set of miRNAs differentially regulated in LCSCs, we applied SP sorting to primary cultures of F344 rat HCC cancer cells treated with diethylnitrosamine (DEN) and normal syngenic fetal liver cells, and the stem-like characteristics of SP cells were verified through detecting expression of CD90.1, AFP and CK-7.
Gene_expression (expression) of CK-7 in stem associated with cancer and hepatocellular cancer
5) Confidence 0.13 Published 2010 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC3022676 Disease Relevance 0.65 Pain Relevance 0
In contrast, expression of CK 7, a biliary marker, was decreased in IPN-L compared with nonpapillary ICC.
Gene_expression (expression) of CK 7 associated with cholangiocarcinoma and ipn
6) Confidence 0.01 Published 2002 Journal Hum. Pathol. Section Abstract Doc Link 12094375 Disease Relevance 0.97 Pain Relevance 1.11

General Comments

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