INT103683

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Context Info
Confidence 0.73
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 20
Disease Relevance 12.47
Pain Relevance 2.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

proteinaceous extracellular matrix (Muc2) nucleus (Muc2) cytoplasm (Muc2)
Anatomy Link Frequency
respiratory 4
colon 2
urinary bladder 1
small intestine 1
goblet cells 1
Muc2 (Mus musculus)
Pain Link Frequency Relevance Heat
IPN 14 99.20 Very High Very High Very High
Inflammation 173 98.54 Very High Very High Very High
Bile 2 98.08 Very High Very High Very High
fibrosis 56 80.32 Quite High
Pain 11 55.48 Quite High
Dysuria 1 54.28 Quite High
addiction 5 48.60 Quite Low
Inflammatory mediators 12 34.84 Quite Low
Inflammatory response 4 8.88 Low Low
Crohn's disease 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Teratoma 90 99.98 Very High Very High Very High
Adenocarcinoma 30 99.52 Very High Very High Very High
Sprains And Strains 10 99.30 Very High Very High Very High
INFLAMMATION 181 98.54 Very High Very High Very High
Injury 27 98.28 Very High Very High Very High
Cholangiocarcinoma 5 96.96 Very High Very High Very High
Colon Cancer 27 95.80 Very High Very High Very High
Diarrhoea 10 94.36 High High
Asthma 7 93.28 High High
Cancer 102 91.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A similar type of inflammation is also observed in two mouse strains with spontaneous mutations in the Muc2 mucin that does not allow the biosynthesis of a functional Muc2 mucin.
Gene_expression (biosynthesis) of Muc2 mucin associated with inflammation and sprains and strains
1) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923597 Disease Relevance 1.20 Pain Relevance 0.32
The MUC2 mucin is a highly glycosylated protein that is produced and secreted by the specialized intestinal goblet cells [4].
Gene_expression (produced) of MUC2 mucin in goblet cells
2) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923597 Disease Relevance 0.07 Pain Relevance 0
The respiratory component of the teratoma expressed MUC1 and MUC1c and the colonic components of the teratoma expressed MUC2 and some MUC6 whilst MUC5AC was expressed in both components.
Gene_expression (expressed) of MUC2 in respiratory associated with teratoma
3) Confidence 0.62 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1852400 Disease Relevance 0.79 Pain Relevance 0
MUC2 was expressed in the colon (Fig. 1e and f) and MUC5AC in both colonic (Fig. 1g and h) and respiratory type epithelia.
Gene_expression (expressed) of MUC2 in colon
4) Confidence 0.62 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1852400 Disease Relevance 0.36 Pain Relevance 0
At days 1 and 4, the peak of expression of the large secreted gel-forming mucin Muc5b was higher for the control group diet in comparison with the n-3 PUFAS treated group suggesting a suppressive effect of n-3 PUFAs on inoculated mice.
Gene_expression (expression) of gel-forming
5) Confidence 0.59 Published 2007 Journal Respir Res Section Body Doc Link PMC1899493 Disease Relevance 0.17 Pain Relevance 0
MUC5AC and MUC2 are expressed in the goblet cells of the superficial airway epithelium, whereas MUC5B is expressed in the mucosal cells of the submucosal glands [9].
Gene_expression (expressed) of MUC2 in glands
6) Confidence 0.59 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.74 Pain Relevance 0.05
A similar type of inflammation is also observed in two mouse strains with spontaneous mutations in the Muc2 mucin that does not allow the biosynthesis of a functional Muc2 mucin.
Gene_expression (biosynthesis) of Muc2 mucin associated with inflammation and sprains and strains
7) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923597 Disease Relevance 1.21 Pain Relevance 0.32
As expected from the immunohistochemistry studies, expression of lysozyme was also strongly reduced in the small intestine as was the expression of the most abundant mucin, Muc 2, in both small intestine and colon (Fig. 7D).
Gene_expression (expression) of Muc 2 in colon
8) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.09 Pain Relevance 0
Western Blotting showed the presence of MUC2, MUC5AC and MUC5B in the sample (Fig. 5).
Gene_expression (presence) of MUC2
9) Confidence 0.54 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1852400 Disease Relevance 0.05 Pain Relevance 0
The other one is made of the five, large secreted gel-forming mucins MUC6, MUC2, MUC5AC, MUC5B and MUC19, which are conserved between human and mouse [13-15] and form oligomeric structures [9,16,17].
Gene_expression (made) of MUC2
10) Confidence 0.53 Published 2007 Journal Respir Res Section Body Doc Link PMC1899493 Disease Relevance 0.51 Pain Relevance 0.16
The tissue showed colonic and respiratory elements, expressed mainly acidic mucin of the sulphated type, in the form of MUC1 MUC1c, MUC2 and lesser MUC5AC and MUC6.



Gene_expression (expressed) of MUC2 in respiratory
11) Confidence 0.48 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1852400 Disease Relevance 1.17 Pain Relevance 0
The respiratory component of the teratoma expressed MUC1 and MUC1c and the colonic components of the teratoma expressed MUC2 and some MUC6.
Gene_expression (expressed) of MUC2 in respiratory associated with teratoma
12) Confidence 0.48 Published 2007 Journal International Journal of Medical Sciences Section Abstract Doc Link PMC1852400 Disease Relevance 0.48 Pain Relevance 0
MUC1 and MUC1c were expressed exclusively in respiratory epithelium, MUC2 and some MUC6 (focal) in the colonic tissue and MUC5AC in both tissues.
Gene_expression (expressed) of MUC2 in respiratory
13) Confidence 0.47 Published 2007 Journal International Journal of Medical Sciences Section Abstract Doc Link PMC1852400 Disease Relevance 0.52 Pain Relevance 0
The other one is made of the five, large secreted gel-forming mucins MUC6, MUC2, MUC5AC, MUC5B and MUC19, which are conserved between human and mouse [13-15] and form oligomeric structures [9,16,17].
Gene_expression (made) of gel-forming
14) Confidence 0.46 Published 2007 Journal Respir Res Section Body Doc Link PMC1899493 Disease Relevance 0.51 Pain Relevance 0.16
Among the identified mucins, the large anchored-mucin MUC4 and the two large gel-forming mucins MUC5B and MUC5AC seem highly expressed in normal and/or abnormal human lung while MUC2 is almost not detectable [18].
Gene_expression (expressed) of gel-forming in lung
15) Confidence 0.46 Published 2007 Journal Respir Res Section Body Doc Link PMC1899493 Disease Relevance 0.36 Pain Relevance 0.09
We observed no differences in MUC5B, MUC2, or MUC6 mRNA expression between mice in the control and the smoke injury groups (data not shown).
Gene_expression (expression) of MUC2 associated with injury
16) Confidence 0.46 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.50 Pain Relevance 0.04
In the present mouse model of smoke inhalation, MUC5AC was the predominant gel-forming mucin gene that was expressed.
Gene_expression (expressed) of gel-forming
17) Confidence 0.40 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.46 Pain Relevance 0.04
As expected from the immunohistochemistry studies, expression of lysozyme was also strongly reduced in the small intestine as was the expression of the most abundant mucin, Muc 2, in both small intestine and colon (Fig. 7D).
Gene_expression (expression) of Muc 2 in small intestine
18) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.09 Pain Relevance 0
Immunohistochemically, cytokeratin (CK) 20 and MUC2, a gastrointestinal marker, were expressed more frequently in IPN-L than in nonneoplastic bile ducts and nonpapillary ICC (P <0.01), and their incidence were significantly increased in parallel with the progression of IPN-L (P < 0.01).
Gene_expression (expressed) of MUC2 in bile ducts associated with bile, cholangiocarcinoma and ipn
19) Confidence 0.12 Published 2002 Journal Hum. Pathol. Section Abstract Doc Link 12094375 Disease Relevance 1.05 Pain Relevance 1.17
Regarding immunohistochemistry, adenocarcinoma of the urinary bladder expresses CEA, CDX-2, MUC-1, MUC-2 and MUC-3, same as colonic adenocarcinoma.
Gene_expression (expresses) of MUC-2 in urinary bladder associated with adenocarcinoma
20) Confidence 0.03 Published 2010 Journal Cases J Section Body Doc Link PMC2824640 Disease Relevance 2.13 Pain Relevance 0.11

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