INT10369

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Context Info
Confidence 0.03
First Reported 1988
Last Reported 1992
Negated 2
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.99
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Spic) DNA binding (Spic)
Anatomy Link Frequency
hypothalamus 1
stalk 1
Spic (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 7 99.90 Very High Very High Very High
Opioid 2 98.36 Very High Very High Very High
Morphine 7 97.96 Very High Very High Very High
cocaine 2 90.08 High High
opiate 2 89.60 High High
imagery 2 87.76 High High
antidepressant 2 87.40 High High
agonist 2 85.12 High High
narcan 2 69.28 Quite High
anesthesia 1 67.12 Quite High
Disease Link Frequency Relevance Heat
Cancer 6 99.24 Very High Very High Very High
Galactorrhea 6 97.74 Very High Very High Very High
Prolactinoma 4 97.40 Very High Very High Very High
Adrenal Insufficiency 2 92.92 High High
Thyroid Disease 2 92.00 High High
Cirrhosis 2 91.36 High High
Renal Insufficiency 2 90.92 High High
Immunization 2 78.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The proestrous surge of PRL could result from a decrease in dopamine, an increase in PRL-releasing factor (PRF) or both.
Positive_regulation (increase) of PRF associated with dopamine
1) Confidence 0.03 Published 1989 Journal Endocrinology Section Abstract Doc Link 2492217 Disease Relevance 0.08 Pain Relevance 0.12
Morphine and related opioids may indirectly stimulate prolactin release by inhibiting PIF release and (or) by stimulating putative PRF release.
Positive_regulation (stimulating) of PRF associated with opioid and morphine
2) Confidence 0.02 Published 1988 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 2907416 Disease Relevance 0 Pain Relevance 0.69
Hyperprolactinemia also may occur from structural lesions of the stalk and hypothalamus, which cause disinhibition with or without maintenance of PRF activity, ectopic neoplasm production, and, most commonly, from prolactinomas.
Neg (without) Positive_regulation (maintenance) of PRF in hypothalamus associated with galactorrhea, prolactinoma and cancer
3) Confidence 0.02 Published 1992 Journal Endocrinol. Metab. Clin. North Am. Section Abstract Doc Link 1486880 Disease Relevance 0.95 Pain Relevance 0.37
Hyperprolactinemia also may occur from structural lesions of the stalk and hypothalamus, which cause disinhibition with or without maintenance of PRF activity, ectopic neoplasm production, and, most commonly, from prolactinomas.
Neg (without) Positive_regulation (maintenance) of PRF in stalk associated with galactorrhea, prolactinoma and cancer
4) Confidence 0.01 Published 1992 Journal Endocrinol. Metab. Clin. North Am. Section Abstract Doc Link 1486880 Disease Relevance 0.95 Pain Relevance 0.37

General Comments

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