INT103699

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Context Info
Confidence 0.24
First Reported 2002
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.42
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (IL15) aging (IL15) Golgi apparatus (IL15)
cell-cell signaling (IL15) cytoplasm (IL15) extracellular space (IL15)
Anatomy Link Frequency
smooth muscle cells 1
lamina 1
synovium 1
IL15 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 41 100.00 Very High Very High Very High
Arthritis 4 98.48 Very High Very High Very High
rheumatoid arthritis 33 96.88 Very High Very High Very High
narcan 1 95.40 Very High Very High Very High
antagonist 3 95.00 High High
opioid receptor 1 94.56 High High
Inflammation 40 89.76 High High
Inflammatory mediators 1 83.68 Quite High
Opioid 2 75.00 Quite High
corticosteroid 37 51.12 Quite High
Disease Link Frequency Relevance Heat
Experimental Arthritis 2 99.00 Very High Very High Very High
Disease 95 98.92 Very High Very High Very High
Rheumatoid Arthritis 33 96.88 Very High Very High Very High
Organ Transplantation 5 95.12 Very High Very High Very High
Arthritis 3 92.64 High High
Cancer 9 91.12 High High
INFLAMMATION 45 89.76 High High
Autoimmune Disease 2 84.72 Quite High
Fungal Infection 2 77.24 Quite High
Celiac Disease 58 77.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Its immunosuppressive effect was further demonstrated by inhibition of interleukin-9 (IL-9), IL-10 but failed to influence IL-2, IL-15 and interferon-y (IFN-gamma) in PPD stimulated human PBMCs.
Neg (failed) Negative_regulation (influence) of IL-15
1) Confidence 0.24 Published 2002 Journal Int. Immunopharmacol. Section Abstract Doc Link 12095165 Disease Relevance 0.08 Pain Relevance 0.37
Furthermore, blockade of IL-1, IL-6 and IL-15 has been tested in both experimental arthritis in rodents [8,9] and in human RA [10-12], with promising results.
Negative_regulation (blockade) of IL-15 associated with rheumatoid arthritis, experimental arthritis and arthritis
2) Confidence 0.10 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833979 Disease Relevance 1.11 Pain Relevance 0.45
In this activated synovium, blockade of Wnt signaling has been shown to lead to a decrease in the level of active cytokines such as IL-6 and IL-15 [90,91].
Negative_regulation (decrease) of IL-15 in synovium associated with cytokine
3) Confidence 0.08 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154434 Disease Relevance 0.34 Pain Relevance 0.09
Moreover, p31–43 potentiates the activation of lamina propria T cells by immunogenic peptides, and this effect is mitigated by IL-15 inhibition [144], suggesting both p31–43 and IL-15 influence the course of the gluten-specific adaptive immune response.
Negative_regulation (inhibition) of IL-15 in lamina
4) Confidence 0.05 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2323203 Disease Relevance 0.65 Pain Relevance 0.19
Sirolimus is a potent immunosuppressant which exerts its immunosuppressive effects by inhibiting IL-2 and IL-15 driven proliferation of hematopoietic (B and T cells) and non hematopoietic cells such as vascular smooth muscle cells [38].
Negative_regulation (inhibiting) of IL-15 in smooth muscle cells
5) Confidence 0.04 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.26 Pain Relevance 0.03

General Comments

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