INT10372

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Context Info
Confidence 0.10
First Reported 1992
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.67
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (ADI1) Golgi apparatus (ADI1) cytoplasm (ADI1)
cytosol (ADI1) oxidoreductase activity (ADI1) nucleolus (ADI1)
Anatomy Link Frequency
arm 1
ADI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
5HT 1 83.08 Quite High
Codeine 1 82.72 Quite High
headache 2 36.72 Quite Low
cva 2 35.60 Quite Low
Pain 2 26.16 Quite Low
aspirin 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Respiratory Disease 7 100.00 Very High Very High Very High
Chromosome Aberrations 1 99.32 Very High Very High Very High
Acute Promyelocytic Leukemia 2 93.24 High High
Influenza Virus Infection 230 72.72 Quite High
Disease 6 66.12 Quite High
Pulmonary Disease 54 63.72 Quite High
Infection 8 62.64 Quite High
Bronchitis 6 61.28 Quite High
Emphysema 5 60.36 Quite High
Disseminated Intravascular Coagulation 1 59.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
APL is associated with a distinct cytogenetic abnormality: translocation of a portion of the long arm chromosome 17 onto the long arm chromosome 15t (15; 17) with a breakpoint on chromosome 17 in the region of the retinoic acid receptor-alpha (RAR-alpha), playing a crucial role in the leukemogenesis of APL.
APL Binding (associated) of in arm associated with chromosome aberrations
1) Confidence 0.10 Published 1992 Journal Harefuah Section Abstract Doc Link 1487198 Disease Relevance 0.38 Pain Relevance 0
Our results are verified by site-directed mutagenesis and electrophysiological experiments, and suggest that APL and ACh bind to different sites on nicotinic receptors and that allosteric potentiation may arise from a direct interplay between both these sites.
APL Binding (bind) of
2) Confidence 0.07 Published 2009 Journal ChemMedChem Section Abstract Doc Link 19739198 Disease Relevance 0.07 Pain Relevance 0.12
Cardiac conditions were the second most frequent group of underlying disorders of patients hospitalized with ARD.
ARD Binding (hospitalized) of associated with respiratory disease
3) Confidence 0.03 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2692112 Disease Relevance 1.22 Pain Relevance 0

General Comments

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