INT103724

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Context Info
Confidence 0.30
First Reported 2002
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.91
Pain Relevance 4.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Oprd1, Gtpbp4) Golgi apparatus (Gtpbp4) GTPase activity (Gtpbp4)
ribosome biogenesis (Gtpbp4) signal transducer activity (Oprd1) nucleolus (Gtpbp4)
Anatomy Link Frequency
brain 2
spinal cord 1
Oprd1 (Rattus norvegicus)
Gtpbp4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 14 100.00 Very High Very High Very High
Spinal cord 8 99.08 Very High Very High Very High
Morphine 20 99.02 Very High Very High Very High
withdrawal 20 96.04 Very High Very High Very High
opiate 6 95.88 Very High Very High Very High
Opioid 12 95.80 Very High Very High Very High
agonist 2 90.64 High High
Enkephalin 2 89.08 High High
amygdala 2 88.88 High High
Nucleus accumbens 2 87.60 High High
Disease Link Frequency Relevance Heat
Substance Withdrawal Syndrome 12 93.80 High High
Arthritis 4 93.04 High High
Urological Neuroanatomy 2 81.36 Quite High
Morphine Dependence 2 75.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study was conducted to measure mu and delta opioid receptor-stimulated G-protein activity in brain and spinal cord of rats 19 days after injection of complete Freund's adjuvant or vehicle.
opioid receptor Positive_regulation (stimulated) of G-protein in spinal cord associated with opioid receptor and spinal cord
1) Confidence 0.30 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15507218 Disease Relevance 0.17 Pain Relevance 0.76
The present lack of differences between morphine-withdrawn and control rats indicates that micro-opioid receptor-stimulated G-protein activity is not modulated by chronic morphine administration and is not involved in the expression of opiate withdrawal.
opioid receptor Positive_regulation (stimulated) of G-protein associated with opiate, opioid receptor, withdrawal and morphine
2) Confidence 0.18 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12098584 Disease Relevance 0.38 Pain Relevance 1.64
The present study investigated the micro-opioid receptor-stimulated G-protein activity using guanylyl 5'-[gamma-[35S]thio]-triphosphate ([35S]-GTPgammaS) autoradiography. [35S]-GTPgammaS binding was performed using coronal rat brain sections (20 microm) in the presence or absence of the micro-opioid selective agonist [D-Ala(2),N-MePhe(4)Gly(5)-ol] enkephalin (DAMGO).
opioid receptor Positive_regulation (stimulated) of G-protein in brain associated with agonist, enkephalin, opioid receptor and opioid
3) Confidence 0.18 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12098584 Disease Relevance 0.18 Pain Relevance 1.01
This study was conducted to measure mu and delta opioid receptor-stimulated G-protein activity in brain and spinal cord of rats 19 days after injection of complete Freund's adjuvant or vehicle.
opioid receptor Positive_regulation (stimulated) of G-protein in brain associated with opioid receptor and spinal cord
4) Confidence 0.10 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15507218 Disease Relevance 0.17 Pain Relevance 0.76

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