INT103726

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Context Info
Confidence 0.10
First Reported 2002
Last Reported 2002
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.38
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Oprd1, Gtpbp4) Golgi apparatus (Gtpbp4) GTPase activity (Gtpbp4)
ribosome biogenesis (Gtpbp4) signal transducer activity (Oprd1) nucleolus (Gtpbp4)
Oprd1 (Rattus norvegicus)
Gtpbp4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 5 100.00 Very High Very High Very High
Morphine 10 99.52 Very High Very High Very High
opiate 3 96.92 Very High Very High Very High
withdrawal 10 96.64 Very High Very High Very High
amygdala 1 88.88 High High
Nucleus accumbens 1 87.60 High High
Locus ceruleus 1 85.88 High High
narcan 4 83.04 Quite High
addiction 1 75.28 Quite High
antagonist 1 70.28 Quite High
Disease Link Frequency Relevance Heat
Substance Withdrawal Syndrome 6 90.32 High High
Morphine Dependence 1 75.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present lack of differences between morphine-withdrawn and control rats indicates that micro-opioid receptor-stimulated G-protein activity is not modulated by chronic morphine administration and is not involved in the expression of opiate withdrawal.
Neg (not) Regulation (modulated) of opioid receptor Positive_regulation (stimulated) of G-protein associated with opiate, opioid receptor, withdrawal and morphine
1) Confidence 0.10 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12098584 Disease Relevance 0.38 Pain Relevance 1.64

General Comments

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